Perforin and IFN-γ not significantly regulate the virus-specific CD8+ T cell response in the absence of antiviral effector activity

European Journal of Immunology

Volumn 34, Issue 5, 2004, Pages 1389-1394

  Christensen, Jeannette E ^a   Wodarz, Dominik ^b   Christensen, Jan P ^a   Thomsen, Allan Randrup ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

CD8+ T cells; IFN ; Immune regulation; Perforin; Virus

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; PERFORIN; T LYMPHOCYTE ANTIGEN; MEMBRANE PROTEIN; PORE FORMING CYTOTOXIC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL KINETICS; CONTROLLED STUDY; GENE TARGETING; IMMUNE RESPONSE; IMMUNOREGULATION; INFECTION CONTROL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION; ANIMAL; CD8+ T LYMPHOCYTE; IMMUNOLOGY; METABOLISM; MOUSE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; INTERFERON TYPE II; MEMBRANE GLYCOPROTEINS; MICE; PORE FORMING CYTOTOXIC PROTEINS; RHABDOVIRIDAE INFECTIONS;

EID: 2942735117     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200424858     Document Type: Article

References (30)

1. Harty, J. T., Tvinnereim, A. R. and White, D. W., CD8+ T cell effector mechanisms in resistance to infection. Annu. Rev. Immunol. 2000. 18: 275-308.
2. Ahmed, R. and Gray, D., Immunological memory and protective immunity: understanding their relation. Science 1996. 272: 54-60.
3. Sprent, J. and Tough, D. F., T cell death and memory. Science 2001. 293: 245-248.
4. Badovinac, V. P. and Harty, J. T., CD8(+) T cell homeostasis after infection: setting the 'curve'. Microbes Infect. 2002. 4: 441-447.
5. + T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2001. 2: 415-422.
6. van Stipdonk, M. J., Lemmens, E. E. and Schoenberger, S. P., Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2001. 2: 423-429.
7. Wong, P. and Pamer, E. G., Cutting edge: antigen-independent CD8 T cell proliferation. J. Immunol. 2001. 166: 5864-5868.
8. Badovinac, V. P., Porter, B. B. and Harty, J. T., Programmed contraction of CD8(+) T cells after infection. Nat. Immunol. 2002. 3: 619-626.
9. + T cell homeostasis by perforin and interferon-gamma. Science 2000. 290: 1354-1358.
10. Zhou, S., Ou, R., Huang, L. and Moskophidis, D., Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection. J. Virol. 2002. 76: 829-840.
11. Matloubian, M., Suresh, M., Glass, A., Galvan, M., Chow, K., Whitmire, J. K., Walsh, C. M., Clark, W. R. and Ahmed, R., A role for perforin in downregulating T cell responses during chronic viral infection. J. Virol. 1999. 73: 2527-2536.
12. Harty, J. T. and Badovinac, V. P., Influence of effector molecules on the CDB(+) T cell response to infection. Curr. Opin. Immunol. 2002. 14: 360-365.
13. Wodarz, D., Mechanisms underlying antigen-specific CD8+ T cell homeostasis. Science 2001. 292: 595.
14. Loyer, V., Fontaine, P., Pion, S., Hetu, F., Roy, D. C. and Perreault, C., The in vivo fate of APC displaying minor H antigen and/or MHC differences is regulated by CTLs specific for immunodominant class I-associated epitopes. J. Immunol. 1999. 163: 6462-6467.
15. Ritchie, D. S., Hermans, I. F., Lumsden, J. M., Scanga, C. B., Roberts, J. M., Yang, J., Kemp, R. A. and Ronchese, F., Dendritic cell elimination as an assay of cytotoxic T lymphocyte activity in vivo. J. Immunol. Methods 2000. 246: 109-117.
16. Ludewig, B., Bonilla, W. V., Dumrese, T., Odermatt, B., Zinkernagel, R. M. and Hengartner, H., Perforin-independent regulation of dendritic cell homeostasis by CD8(+) T cells in vivo: implications for adaptive immunotherapy. Eur. J. Immunol. 2001. 31: 1772-1779.
17. Ou, R., Zhou, S., Huang, L. and Moskophidis, D., Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells. J. Virol. 2001. 75: 8407-8423.
18. Lohman, B. L. and Welsh, R. M., Apoptotic regulation of T cells and absence of immune deficiency in virus-infected gamma interferon receptor knockout mice. J. Virol. 1998. 72: 7815-7821.
19. Andersen, C., Jensen, T., Nansen, A., Marker, O. and Thomsen, A. R., CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int. Immunol. 1999. 11: 2035-2042.
20. Thomsen, A. R., Nansen, A., Andersen, C., Johansen, J., Marker, O. and Christensen, J. P., Cooperation of B cells and T cells is required for survival of mice infected with vesicular stomatitis virus. Int. Immunol. 1997. 9: 1757-1766.
21. Muller, U., Steinhoff, U., Reis, L. F., Hemmi, S., Pavlovic, J., Zinkernagel, R. M. and Aguet, M., Functional role of type I and type II interferons in antiviral defense. Science 1994. 264: 1918-1921.
22. + effector T cell responses. J. Immunol. 2000. 164: 3689-3697.
23. Charan, S., Huegin, A. W., Cerny, A., Hengartner, H. and Zinkernagel, R. M., Effects of cyclosporin A on humoral immune response and resistance against vesicular stomatitis virus in mice. J. Virol. 1986. 57: 1139-1144.
24. Jensen, E. R., Glass, A. A., Clark, W. R., Wing, E. J., Miller, J. F. and Gregory, S. H., Fas (CD95)-dependent cell-mediated immunity to Listeria monocytogenes. Infect. Immun. 1998. 66: 4143-4150.
25. Gallimore, A., Glithero, A., Godkin, A., Tissot, A. C., Pluckthun, A., Elliott, T., Hengartner, H. and Zinkernagel, R., Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J. Exp. Med. 1998. 187: 1383-1393.
26. Hildeman, D. A., Zhu, Y., Mitchell, T. C., Kappler, J. and Marrack, P., Molecular mechanisms of activated T cell death in vivo. Curr. Opin. Immunol. 2002. 14: 354-359.
27. Bartholdy, C., Christensen, J. P., Wodarz, D. and Thomsen, A. R., Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in gamma interferon-deficient mice infected with lymphocytic choriomeningitis virus. J. Virol. 2000. 74: 10304-10311.
28. + T cells precipitates immunopathology in immunodeficient mice infected with a noncytocidal virus. J. Immunol. 2001. 166: 3384-3391.
29. Nansen, A., Jensen, T., Christensen, J. P., Andreasen, S. O., Ropke, C., Marker, O. and Thomsen, A. R., Compromised virus control and augmented perforin-medlated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus. J. Immunol. 1999. 163: 6114-6122.
30. Christensen, J. E., Christensen, J. P., Kristensen, N. N., Hansen, N. J., Stryhn, A. and Thomsen, A. R., Role of CD28 costimulation in generation and maintenance of virus-specific T cells. Int. Immunol. 2002. 14: 701-711.