CD4+ T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-γ or IL-4

International Immunology

Volumn 11, Issue 12, 1999, Pages 2035-2042

  Andersen, Camilla ^a   Jensen, Teis ^a   Nansen, Anneline ^a   Marker, Ole ^a   Thomsen, Allan Randrup ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Antibodies; CD4+ T cells; T cell mediated immunity; Viral infection

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN GP 39; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PERFORIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; FEMALE; INFECTION SENSITIVITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VESICULAR STOMATITIS VIRUS; VIRUS IMMUNITY; VIRUS INFECTION;

EID: 0033429132     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.12.2035     Document Type: Article

References (39)

1. + T cell mechanisms in the control of respiratory virus infections. Immunol. Rev. 159:105.
2. Kägi, D., Ledermann, B., Bürki, K., Seiler, P., Odermatt, B., Olsen, K. J., Podack, E. R., Zinkernagel, R. M. and Hengartner, H. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31.
3. Walsh, C. M., Matloubian, M., Liu, C.-C., Ueda, R., Kurahara, C. G., Chrisensen, J. L., Huang, M. T. F., Yong, J. D.-E., Ahmed, R. and Clark, W. R. 1994. Immune function in mice lacking the perforin gene. Proc. Natl Acad. Sci. USA 91:10854.
4. + T cells clear influenza virus by perforin or Fas-dependent processes. J. Immunol. 159:5197.
5. Ramsay, A. J., Ruby, J. and Ramshaw, I. A. 1993. A case for cytokines as effector molecules in the resolution of virus infection. Immunol. Today 14:155.
6. Ramshaw, I. A., Ramsay, A. J., Karupiah, G., Rolph, M. S., Mahalingam, S. and Ruby, J. C. 1997. Cytokines and immunity to viral infections. Immunol Rev. 159:119.
7. + T helper type 2 T lymphocytes do not promote recovery from experimental virus infection. J. Exp. Med. 180:1273.
8. Gerhard, W., Mozdzanowska, K., Furcher, M., Washko, G. and Maiese, K. 1997. Role of the B cell response in recovery of mice from primary influenza virus infection. Immunol. Rev. 159:95.
9. Coutelier, J.-P., Van der Logt, J. T. M., Heesen, F. W. A., Warnier, G. and Van Snick, J. 1987. IgG2a restriction of murine antibodies elicited by viral infections. J. Exp. Med. 165:64.
10. h1-characteristic cytokine profiles but altered antibody responses. J. Immunol. 153:2029.
11. + T cells is inefficient in the absence of B cells. J. Virol. 72:882.
12. + T cells are ineffective in clearing a pulmonary infection with influenza type A virus in the absence of B cells. Virology 239:217.
13. Graham, M. B. and Braciale, T. J. 1997. Resistance to and recovery from lethal influenza virus infection in B lymphocyte-deficient mice. J. Exp. Med. 186:2063.
14. Wagner, R. R. 1987. The Rabdoviruses. Plenum Press, New York,
15. Schattner, A., Meshorer, A. and Wallach, D. 1983. Involvement of IFN in virus-induced lymphopenia. Cell. Immunol. 79:11.
16. Charan, S. and Zinkernagel, R. M. 1986. Antibody mediated suppression of secondary IgM response in Nude mice against vesicular stomatitis virus. J. Immunol. 136:3057.
17. Freer, G., Burkhart, C., Ciernik, I., Bachmann, M. F., Hengartner, H., and Zinkernagel, R. M. 1994. Vesicular stomatitis virus Indiana glycoprotein as a T-cell-dependent and -independent antigen. J. Virol. 68:3650.
18. Zinkernagel, R. M., Althage, A. and Holland, J. 1978. Target antigens for H-2-restricted vesicular stomatitis virus-specific cytotoxic T cells. J. Immunol. 121:744.
19. Barna, M., Komatsu, T., Bi, Z. and Reiss, C. S. 1996. Sex difference in susceptibility to viral infection of the central nervous system. J. Neuroimmunol. 67:39.
20. Kägi, D., Seiler, P., Pavlovic, J., Ledermann, B., Bürki, K., Zinkernagel, R. M. and Hengartner, H. 1995. The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur. J. Immunol. 25:3256.
21. Thomsen, A. R., Nansen, A., Andersen, C., Johansen, J., Marker, O. and Christensen, J. P. 1997. Cooperation of B cells and T cells is required for survival of mice infected with vesicular stomatitis virus. Int. Immunol. 9:1757.
22. Huneycutt, B. S., Bi, Z., Aoki, C. and Reiss, C. S. 1993. Central neuropathogenesis of vesicular stomatitis virus infection in immunodeficient mice. J. Virol. 67:6698.
23. Gresser, I., Tovey, M. G., Maury, C. and Bandu, M.-T. 1976. Role of IFN in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-IFN serum. J. Exp. Med. 144:1316.
24. Müller, U., Steinhoff, U., Reiss, L. F. L., Hemmi, S., Pavlovic, J., Zinkernagel, R. M. and Aguet, M. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:1918.
25. Steinhoff, U., Müller, U., Schertler, A., Hengartner, H., Aguet, M. and Zinkernagel, R. M. 1995. Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta Interferon receptor-deficient mice. J. Virol. 69:2153.
26. Thomsen, A. R., Johansen, J., Marker, O. and Christensen, J. P. 1996. Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice. J. Immunol. 157:3074.
27. + T cells facilitates homing to inflammatory sites. J. Immunol. 153:2021.
28. Scott, D. W. and Gershon, R. K. 1970. Determination of total and mercaptoethanol-resistant antibody in the same serum sample. Clin. Exp. Immunol. 6:313.
29. + t cells correlating with cytotoxic activity in vitro are more efficient in antivaccinia virus protection than CD4-dependent IL. J. Immunol. 146:4301.
30. + T-cell immunity to murine rotavirus in the absence of perforin, Fas and gamma interferon. J. Virol. 71:479.
31. Usherwood, E. J., Brooks, J. W., Sarawar, S. R., Cardin, R. D., Young, W. D., Allen, D. J. D. P. and Nash, A. A. 1997. Immunological control of murine gammaherpesvirus infection is independent of perforin. J. Gen. Virol. 78:2025.
32. Sarawar, S. R., Cardin, R. D., Brooks, J. W., Mehrpooya, M., Hamilton-Easton, A. M., Mo, X. Y. and Doherty, P. C. 1997. Gamma IFN is not essential for recovery from acute infection with murine gammaherpesvirus 68. J. Virol. 71:3916.
33. Grusby, M. J., Auchincloss, H., Jr, Lee, R., Johnson, R. S., Spencer, J. P., Zijlstra, M., Jaenisch, R., Papaioannou, V. E. and Glimcher, L. H. 1993. Mice lacking major histocompatibility complex class I and class II molecules. Proc. Natl Acad. Sci. USA 90:3913.
34. + CTL response. J. Exp. Med. 183:2129.
35. + T cell functions. J. Exp. Med. 183:2209.
36. Fikrig, E., Barthold, S. W., Chen, M., Grewal, I. S., Craft, J. and Flavell, R. A. 1996. Protective antibodies in murine Lyme disease arise independently of CD40 ligand. J. Immunol. 157:1.
37. Whitmire, J. K., Slifka, M. K., Grewal, I. S., Flavell, R. A. and Ahmed, R. 1996. CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection. J. Virol. 70:8375.
38. Maloy, K. J., Odermatt, B., Hengartner, H. and Zinkernagel, R. M. 1998. Interferon γ-producing γδ T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection. Proc. Natl Acad. Sci. USA 95:1160.
39. Battegay, M., Bachmann, M. F., Burkhart, C., Viville, S., Benoist, C., Mathis, D., Hengartner, H. and Zinkernagel, R. M. 1996. Antiviral immune responses of mice lacking MHC class II or its associated invariant chain. Cell. Immunol. 167:115.