A dual role for Hox genes in limb anterior-posterior asymmetry

Science

Volumn 304, Issue 5677, 2004, Pages 1669-1672

  Zákány, József ^a   Kmita, Marie ^a   Duboule, Denis ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; PERTURBATION TECHNIQUES;

DIFFUSION PRODUCTS; GENE EXPRESSION; LIMBS;

GENETIC ENGINEERING;

GL13 PROTEIN; PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYO DEVELOPMENT; GENE; GENE CLUSTER; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOME; HOX GENE; HOXA GENE; HOXD GENE; HOXD1 GENE; HOXD11 GENE; HOXD12 GENE; HOXD13 GENE; HOXD3 GENE; LIMB BUD; LIMB DEVELOPMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHH GENE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BODY PATTERNING; DNA-BINDING PROTEINS; FORELIMB; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; GENES, HOMEOBOX; HEDGEHOG PROTEINS; HETEROZYGOTE; HINDLIMB; HOMEODOMAIN PROTEINS; HOMOZYGOTE; INVERSION, CHROMOSOME; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIMB BUD; MICE; MORPHOGENESIS; NERVE TISSUE PROTEINS; RECOMBINATION, GENETIC; SIGNAL TRANSDUCTION; TOES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; ZEBRAFISH PROTEINS;

ERINACEIDAE;

EID: 2942694533     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1096049     Document Type: Article

References (33)

1. C. Tickle, Int. J. Dev. Biol. 46, 847 (2002).
2. R. D. Riddle, R. L. Johnson, E. Laufer, C. Tabin, Cell 75, 1401 (1993).
3. R. Dillon, C. Cadgil, H. G. Othmer, Proc. Natl. Acad. Sci. U.S.A. 100, 10152 (2003).
4. G. Drossopoulou et al., Development 127, 1337 (2000).
5. M. A. Ros et al., Development 130, 527 (2003).
6. P. Kraus, D. Fraidenraich, C. A. Loomis. Mech. Dev. 100, 45 (2001).
7. J. Sharpe et al., Curr. Biol. 9, 97 (1999).
8. H. Masuya, T. Sagai, S. Wakana, K. Moriwaki, T. Shiroishi, Genes Dev. 9, 1645 (1995).
9. C. J. Neumann, H. Grandel, W. Gaffield, S. Schulte-Merker, C. Nusslein-Vothard, Development 126, 4817 (1999).
10. B. Wang, J. F. Fallon, P. A. Beachy, Cell 100, 423 (2000).
11. P. te Welscher et al., Science 298, 827 (2002).
12. Y. Litingtung, R. D. Dahn, Y. Li, J. F. Fallon, C. Chiang, Nature 418, 979 (2002).
13. F. Spitz, F. Gonzalez, D. Duboule, Cell 113, 405 (2003).
14. M. Kmita, N. Fraudeau, Y. Herault, D. Duboule, Nature 420, 145 (2002).
15. P. te Welscher, M. Fernandez-Teran, M. A. Ros, R. Zeller, Genes Dev. 16, 421 (2002).
16. J. Charite, D. G. McFadden, E. N. Olson, Development 127, 2461 (2000).
17. M. Femandez-Teran et al., Development 127, 2133 (2000).
18. D. Buscher, B. Bosse, J. Heymer, U. Ruther, Mech. Dev. 62, 175 (1997).
19. P. Dolle, J. C. Izpisua-Belmonte, H. Falkenstein, A. Renucci, D. Duboule, Nature 342, 767 (1989).
20. H. Haack, P. Gruss, Dev. Biol. 157, 410 (1993).
21. C. E. Nelson et al., Development 122, 1449 (1996).
22. U. Grieshammer, G. Minowada, J. M. Pisenti, U. K. Abbott, G. R. Martin, Development 122, 3851 (1996).
23. J. Charite, W. de Graaff, S. Shen, J. Deschamps, Cell 78, 589 (1994).
24. V. Knezevic et al., Development 124, 4523 (1997).
25. S. Mackem, V. Knezevic, Cell Tissue Res. 296, 27 (1999).
26. A. Zuniga, R. Zeller, Development 126, 13 (1999).
27. F. van der Hoeven, J. Zakany, D. Duboute, Cell 85, 1025 (1996).
28. F. Vidal, J. Sage, F. Cuzin, M. Rassoulzadegan, Mol. Reprod. Dev. 51, 274 (1998).
29. Y. Herault, M. Rassoulzadegan, F. Cuzin, D. Duboule, Nat. Genet. 20, 381 (1998).
30. J. Zakany, M. Kmita, P. Alarcon, J. L. de la Pompa, D. Duboule, Cell 106, 207 (2001).
31. J. Zakany, M. Gerard, B. Favier, D. Duboule, EMBO J. 16, 4393 (1997).
32. P. M. Lewis et al., Cell 105, 599 (2001).
33. We thank M. Friedli and N. Fraudeau for technical assistance; J. Deschamps, C. Tabin, J. Cobb, and P. Vassalli for comments; and J. Deschamps, A. Zuniga, D. Srivastava, and A. McMahon for probes. This work was supported by funds from the Canton de Genève, the Swiss National Research Fund, the Claraz and Louis-Jeantet foundations and European Union grants "Eumorphia" and "Cells into Organs."