Analysis of Hox gene expression in the chick limb bud

Development

Volumn 122, Issue 5, 1996, Pages 1449-1466

  Nelson, Craig E ^a   Morgan, Bruce A ^b   Burke, Ann C ^a   Laufer, Ed ^a   DiMambro, Enrico ^a   Murtaugh, L Charles ^a   Gonzales, Ellen ^b   Tessarollo, Lino ^c   Parada, Luis F ^d   Tabin, Cliff ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Chick; Hox; Limb; Pattern; Sonic hedgehog

Indexed keywords

PROTEIN; RNA;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHICKEN; CHROMOSOME; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO; EMBRYO PATTERN FORMATION; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE ISOLATION; GENE ORDER; GENETIC TRANSCRIPTION; LIMB BUD; LIMB DEVELOPMENT; MESENCHYME; MESODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL MOVEMENT; CHICK EMBRYO; EXTREMITIES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE LIBRARY; GENES, HOMEOBOX; HEDGEHOG PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; MUSCLES; POLYMERASE CHAIN REACTION; PROTEINS; TIME FACTORS; TISSUE DISTRIBUTION; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

ANIMALIA; ERINACEIDAE; GALLUS GALLUS; VERTEBRATA;

EID: 15844372073     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Ahlberg, P. E. and Milner, A. R. (1994). The origin and early diversification of tetrapods. Nature 368, 507-513.
2. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. and Lipman, D. J. (1990). Basic local alignment search tool. J. Mol. Biol. 215, 403-410.
3. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. and Struhl, K., Ed. (1989). Current Protocols in Molecular Biology. New York, Greene Publishing Associates and Wiley Interscience.
4. Bittner, D., De Robertis, E. M. and Cho, K. W. (1993) Characterization of the Xenopus Hox 2.4 gene and identification of control elements in its intron. Dev. Dynam. 196, 11-24.
5. Burke, A. C., Nelson, C. E., Morgan, B. A. and Tabin, C. (1995). Hox genes and the evolution of vertebrate axial morphology. Development 121, 333-346.
6. Charite, J., de Graaff, W., Shen, S. and Deschamps, J. (1994). Ectopic expression of Hoxb-8 causes duplication of the ZPA in the fore limb and homeotic transformation of axial structures. Cell 78, 589-601.
7. Cho, K. W., Goetz, J., Wright, C. V., Fritz, A., Hardwicke, J. and De Robertis, E. M. (1988). Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity. EMBO J. 7, 2139-2149.
8. Church, G. M. and Gilbert, W. (1984). Genomic sequencing. Proc. Nat. Acad. Sci. USA 81, 1991-1995.
9. Coates, M. I. (1995). Fish fins or tetrapod limbs - a simple twist of fate? Curr. Biol. 5, 844-848.
10. Davis, A. P. and Capecchi, M. R. (1994). Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. Development 120, 2187-2198.
11. Davis, A. P., Witte, D. P., Hsieh-Li, H. M., Potter, S. S. and Capecchi, M. R. (1995). Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 375, 791-795.
12. Devereux, J., Haeberli, P. and Smithies, O. (1984). A comprehensive set of sequence analysis programs for the VAX. Nucl. Acids Res. 12, 387-394.
13. Dolle, P., Dierich, A., LeMeur, M., Schimmang, T., Schuhbaur, B., Chambon, P. and Duboule, D. (1993). Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75, 431-441.
14. Dolle, P., Izpisua-Belmonte, J. C., Brown, J. M., Tickle, C. and Duboule, D. (1991). HOX-4 genes and the morphogenesis of mammalian genitalia. Genes Dev. 5, 1767-1767.
15. Dolle, P., Izpisua-Belmonte, J. C., Falkenstein, H., Renucci, A. and Duboule, D. (1989). Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature 342, 767-772.
16. Duboule, D. (1994). How to make a limb? Science 266, 575-576.
17. Erselius, J. R., Goulding, M. D. and Gruss, P. (1990). Structure and expression pattern of the murine Hox-3. 2 gene. Development 110, 629-642.
18. Favier, B., Le Meur, M., Chambon, P. and Dolle, P. (1995). Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice. Proc. Nat. Acad. Sci. USA 92, 310-314.
19. Gerard, M., Duboule, D. and Zakany, J. (1993). Cooperation of regulatory elements involved in the activation of the Hoxd-11 gene. CR Acad. Sci. III 316, 985-994.
20. Gumpel-Pinot, M. (1984). Muscle and skeleton of the limbs and bodywall. In Chimeras in Developmental Biology (ed. L. N. M. and McLaren), pp. 281-310. London: Academic Press.
21. Hamburger, V. and Hamilton, H. L. (1951). A series of normal stages in the development of the chick embryo. J. Exp. Morphol. 88, 49-92.
22. Izpisua-Belmonte, J. C., Brown, J. M., Duboule, D. and Tickle, C. (1992). Expression of Hox-4 genes in the chick wing links pattern formation to the epithelial-mesenchymal interactions that mediate growth. EMBO J. 11, 1451-1457.
23. Izpisua-Belmonte, J. C., Tickle, C., Dolle, P., Wolpert, L. and Duboule, D. (1991). Expression of the homeobox Hox-4 genes and the specification of position in chick wing development. Nature 350, 585-589.
24. Jegalian, B. G. and De Robertis, E. M. (1992). Homeotic transformations in the mouse induced by overexpression of a human Hox3. Cell 71, 901-910.
25. Jegalian, B. G., Miller, R. W., Wright, C. V., Blum, M. and De Robertis, E. M. (1992). A Hox 3. 3-lacZ transgene expressed in developing limbs. Mech. Dev. 39, 171-180.
26. Kessel, M. and Gruss, P. (1990). Murine developmental control genes. Science 249, 374-379.
27. Krumlauf, R. (1992). Evolution of the vertebrate Hox homeobox genes. BioEssays 14, 245-252.
28. Krumlauf, R. (1993). Mouse Hox genetic functions. Curr. Opin. Genet. Dev. 3, 621-625.
29. Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A. and Tabin, C. (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.
30. Le Mouellic, H., Lallemand, Y. and Brulet, P. (1992). Homeosis in the mouse induced by a null mutation in the Hox-3. 1. Cell 69, 251-264.
31. Mackem, S. and Mahon, K. A. (1991). Ghox 4. 7: a chick homeobox gene expressed primarily in limb buds with limb-type differences in expression. Development 112, 791-806.
32. Mackem, S., Ranson, M. and Mahon, K. (1993). Limb-type differences in expression domains of certain chick Hox-4 genes and relationship to pattern modification for flight. Prog. Clin. Biol. Res. 21-30.
33. Molven, A., Wright, C. V., Bremiller, R., De Robertis, E. M. and Kimmel, C. B. (1990). Expression of a homeobox gene product in normal and mutant zebrafish embryos: evolution of the tetrapod body plan. Development 109, 279-288.
34. Morgan, B. A., Izpisua-Belmonte, J. C., Duboule, D. and Tabin, C. J. (1992). Targeted misexpression of Hox-4. 6 in the avian limb bud causes apparent homeotic transformations. Nature 358, 236-239.
35. Morgan, B. A. and Tabin, C. J. (1994). Hox genes and growth: early and late effects on limb bud morphogenesis. Development (suppl.) 181-186.
36. Niswander, L., Jeffrey, S., Martin, G. R. and Tickle, C. (1994). A positive feedback loop coordinates growth and patterning in the vertebrate limb [see comments]. Nature 371, 609-612.
37. Nohno, T., Noji, S., Koyama, E., Ohyama, K., Myokai, F., Kuriowa, A., Saito, T. and Taniguchi, S. (1991). Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development. Cell 64, 1197-1205.
38. Oliver, G., De Robertis, E. M., Wolpert, L. and Tickle, C. (1990) Expression of a homeobox gene in the chick wing bud following application of retinoic acid and grafts of polarizing region tissue. EMBO J. 9, 3093-3099.
39. Oliver, G., Wright, C. V., Hardwicke, J. and De Robertis, E. M. (1988a). Differential antero-posterior expression of two proteins encoded by a homeobox gene in Xenopus and mouse embryos. EMBO J. 7. 3199-3209.
40. Oliver, G., Wright, C. V., Hardwicke, J. and De Robertis, E. M. (1988b). A gradient of homeodomain protein in developing forelimbs of Xenopus and mouse embryos. Cell 55, 1017-1024.
41. Peterson, R. L., Jacobs, D. F. and Awgulewitsch, A. (1992). Hox-3. 6: isolation and characterization of a new murine homeobox gene located in the 5′ region of the Hox-3 cluster. Mech. Dev. 37, 151-166.
42. Peterson, R. L., Papenbrock, T., Davda, M. M. and Awgulewitsch, A. (1994). The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions. Mech. Dev. 47, 253-260.
43. Pollock, R. A., Jay, G. and Bieberich, C. J. (1992). Altering the boundaries of Hox3. 1 expression: evidence for antipodal gene regulation. Cell 71, 911-923.
44. Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C. (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.
45. Saunders, J. Jr. (1948). The Proximo-Distal Sequence of Origin of the Parts of the Chick Wing and the Role of the Ectoderm. J. Exp. Zool. 108, 363.
46. Schughart, K., Pravtcheva, D., Newman, M. S., Hunihan, L. W., Jiang, Z. L. and Ruddle, F. H. (1989). Isolation and regional localization of the murine homeobox-containing gene Hox-3.3. Genomics 5, 76-83.
47. Scott, M. P. (1992). Vertebrate homeobox gene nomenclature. Cell 71, 551-553.
48. Scotting, P. J., Hewitt, M., Keynes, R. J. (1990). Isolation and analysis of chick homeobox cDNA clones. Nucl. Acids Res. 18, 3999.
49. Shimeld, S. M., Gaunt, S. J., Coletta, P. L., Geada, A. M. and Sharpe, P. T. (1993). Spatial localisation of transcripts of the Hox-C6 gene. J. Anat. 183, 515-523.
50. Shubin, N. H. and Alberch, P. (1986). A morphogenetic approach to the origin and basic organization of the tetrapod limb. Evol. Biol. 20, 319-387.
51. Simeone, A., Acampora, D., Nigro, V., Faiella, A., D'Esposito, M., Stornaiuolo, A., Mavilio, F. and Boncinelli, E. (1991). Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells. Mech. Dev. 33, 215-227.
52. Small, K. M. and Potter, S. S. (1993). Homeotic transformations and limb defects in Hox A11 mutant mice. Genes Dev. 7, 2318-2328.
53. Sordino, P., van der Hoeven, F. and Duboule, D. (1995). Hox gene expression in teleost fins and the origin of vertebrate digits. Nature 375, 678-681.
54. Suemori, H., Takahashi, N. and Noguchi, S. (1995). Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs. Mech. Dev. 51, 265-273.
55. Summerbell, D., Lewis, J. H. and Wolpert, L. (1973). Positional information in chick limb morphogenesis. Nature 244, 492-496.
56. Tabin, C. J. (1991). Retinoids, homeoboxes, and growth factors: toward molecular models for limb development. Cell 66, 199-217.
57. Tessarollo, L., Nagarajan, L. and Parada, L. F. (1992). c-ros: the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development. Development 115, 11-20.
58. Wall, N. A., Jones, C. M., Hogan, B. L. and Wright, C. V. (1992). Expression and modification of Hox 2. 1 protein in mouse embryos. Mech. Dev. 37, 111-120.
59. Wedden, S. E., Pang, K. and Eichele, G. (1989). Expression pattern of humeobox-containing genes during chick embryogenesis. Development 105, 639-650.
60. Williams, B. A. and Ordahl, C. P. (1994). Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification. Development 120, 785-796.
61. Yokouchi, Y., Sasaki, H. and Kuroiwa, A. (1991). Homeobox gene expression correlated with the bifurcation process of limb cartilage development. Nature 353, 443-445.
62. Yokouchi, Y., Nakazato, S., Yamamoto, M., Goto, Y., Kameda, T., Iba, H. and Kuroiwa, A. (1995). Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes Dev. 9, 2509-2522.