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1
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0345099650
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Cooperativity, partially bound states, and enthalpy-entropy compensation
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Hunter uses simple host-guest systems and a chemical double-mutant cycle to probe cooperative binding interactions between functional groups. The results suggest new rationales for cooperative phenomena, the enthalpic chelate effect and enthalpy-entropy compensation.
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Hunter C.A., Tomas S. Cooperativity, partially bound states, and enthalpy-entropy compensation. Chem Biol. 10:2003;1023-1032 Hunter uses simple host-guest systems and a chemical double-mutant cycle to probe cooperative binding interactions between functional groups. The results suggest new rationales for cooperative phenomena, the enthalpic chelate effect and enthalpy-entropy compensation.
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Chem Biol
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Hunter, C.A.1
Tomas, S.2
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0035801512
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Sensing a paradigm shift in the field of molecular recognition: From selective to differential receptors
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An excellent review of recent advances in receptor development, both rational and combinatorial, and in which Anslyn introduces the concept of 'differential' receptors (i.e. receptors that each have different binding properties, but none of them is necessarily very specific or selective), and describes the application of such receptors to sensors.
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Lavigne J.J., Anslyn E.V. Sensing a paradigm shift in the field of molecular recognition: from selective to differential receptors. Angew Chem Int Ed Engl. 40:2001;3118-3130 An excellent review of recent advances in receptor development, both rational and combinatorial, and in which Anslyn introduces the concept of 'differential' receptors (i.e. receptors that each have different binding properties, but none of them is necessarily very specific or selective), and describes the application of such receptors to sensors.
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Angew Chem Int Ed Engl
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Lavigne, J.J.1
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Discovery of sequence-selective peptide binding by synthetic receptors using encoded combinatorial libraries
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Dynamic covalent chemistry
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Rowan S.J., Cantrill S.J., Cousins G.R.L., Sanders J.K.M., Stoddart J.F. Dynamic covalent chemistry. Angew Chem Int Ed Engl. 41:2002;898-952
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Combinatorial methods in molecular imprinting
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Batra D., Shea K.J. Combinatorial methods in molecular imprinting. Curr Opin Chem Biol. 7:2003;434-442
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Molecular tweezers: A simple model of bifunctional intercalation
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Chen C.W., Whitlock H.W. Jr. Molecular tweezers: a simple model of bifunctional intercalation. J Am Chem Soc. 100:1978;4921-4922
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Flexible but with a defined turn - Influence of the template on the binding properties of two-armed receptors
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Diamino diketopiperazines and several other diamines are evaluated as possible scaffolds for construction of tweezer receptors, highlighting the importance of using a suitable scaffold to preorganise the binding arms of the receptors.
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Wennemers H., Nold M.C., Conza M., Kulicke K.J., Neuburger M. Flexible but with a defined turn - influence of the template on the binding properties of two-armed receptors. Chemistry. 9:2003;442-448 Diamino diketopiperazines and several other diamines are evaluated as possible scaffolds for construction of tweezer receptors, highlighting the importance of using a suitable scaffold to preorganise the binding arms of the receptors.
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Chemistry
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Wennemers, H.1
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11
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0037134147
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Selective binding of two-armed diketo-piperazine receptors to side-chain-protected peptides
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Conza M., Wennemers H. Selective binding of two-armed diketo-piperazine receptors to side-chain-protected peptides. J Org Chem. 67:2002;2696-2698
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Conza, M.1
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12
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0035805285
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Identification of sequence selective receptors for peptides with a carboxylic acid terminus
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Screening experiments with diamidopyridine-derived receptor libraries, using dye-labeled substrates highlight how the dye label can influence the binding of the substrate.
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Braxmeier T., Demarcus M., Fessmann T., McAteer S., Kilburn J.D. Identification of sequence selective receptors for peptides with a carboxylic acid terminus. Chemistry. 7:2001;1889-1898 Screening experiments with diamidopyridine-derived receptor libraries, using dye-labeled substrates highlight how the dye label can influence the binding of the substrate.
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Chemistry
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Braxmeier, T.1
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0037148009
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Combinatorial libraries of diamidopyridine-derived 'tweezer' receptors and sequence selective binding of peptides
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Arienzo R., Kilburn J.D. Combinatorial libraries of diamidopyridine- derived 'tweezer' receptors and sequence selective binding of peptides. Tetrahedron. 58:2002;711-719
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Arienzo, R.1
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14
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85047696497
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Synthesis of guanidinium-derived receptor libraries and screening for selective peptide receptors in water
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Libraries of 'tweezer' receptors with a guanidinium head group and peptidic side arms lead to identification of receptors able to bind short peptidic substrates in aqueous media.
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Jensen K.B., Braxmeier T.M., Demarcus M., Frey J.G., Kilburn J.D. Synthesis of guanidinium-derived receptor libraries and screening for selective peptide receptors in water. Chemistry. 8:2002;1300-1309 Libraries of 'tweezer' receptors with a guanidinium head group and peptidic side arms lead to identification of receptors able to bind short peptidic substrates in aqueous media.
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Chemistry
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Jensen, K.B.1
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15
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0344012530
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Peptide binding by one-armed receptors in water: Screening of a combinatorial library for the binding of Val-Val-Ile-Ala
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Structurally simple receptors consisting of a peptide sequence capped by a guanidinocarbonyl pyrrole were screened to identify receptors for the C-terminal sequence of amyloid β-peptide.
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Schmuck C., Heil M. Peptide binding by one-armed receptors in water: screening of a combinatorial library for the binding of Val-Val-Ile-Ala. ChemBioChem. 4:2003;1232-1238 Structurally simple receptors consisting of a peptide sequence capped by a guanidinocarbonyl pyrrole were screened to identify receptors for the C-terminal sequence of amyloid β-peptide.
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ChemBioChem
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Schmuck, C.1
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16
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0042508739
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Using combinatorial methods to arrive at a quantitive structure-stability relationship for a new class of one-armed cationic peptide receptors targeting the C-terminus of the amyloid β-peptide
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Schmuck C., Heil M. Using combinatorial methods to arrive at a quantitive structure-stability relationship for a new class of one-armed cationic peptide receptors targeting the C-terminus of the amyloid β-peptide. Org Biomol Chem. 1:2003;633-636
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Schmuck, C.1
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17
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0242439326
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Dimerisation inhibitors of HIV-1 protease based on a bicyclic guanidinium subunit
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Breccia P., Boggetto N., Pérez-Fernández R., Van Gool M., Takahashi M., René L., Prados P., Badet B., Reboud-Ravaux M., de Mendoza J. Dimerisation inhibitors of HIV-1 protease based on a bicyclic guanidinium subunit. J Med Chem. 46:2003;5196-5207
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Breccia, P.1
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De Mendoza, J.10
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18
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0037035051
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3V-symmetric tripodal scaffold, triethyl cis,cis,cis-2,5,8-tribenzyltrindane-2,5,8-tricarboxylate, for the construction of artificial receptors
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3V-symmetric tripodal scaffold, triethyl cis, cis, cis-2, 5, 8-tribenzyltrindane-2, 5, 8-tricarboxylate, for the construction of artificial receptors. Org Lett. 4:2002;795-798
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Choi, H.J.1
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19
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0344542232
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Steroidal ureas as enantioselective receptors for an N-acetyl α-amino carboxylate
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Siracusa L., Hurley F.M., Dresen S., Lawless L.J., Pérez- Payán M.N., Davis A.P. Steroidal ureas as enantioselective receptors for an N-acetyl α-amino carboxylate. Org Lett. 4:2002;4639-4642
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20
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0037073927
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Dual binding mode of methylmethanetriacetic acid to tripodal amidopyridine receptors
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Ballester P., Capó M., Costa A., Deyà P.M., Gomila R., Decken A., Deslongchamps G. Dual binding mode of methylmethanetriacetic acid to tripodal amidopyridine receptors. J Org Chem. 67:2002;8832-8841
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Ballester, P.1
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0037123785
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3-symmetric molecular scaffolds with potential facial differentiation
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3-symmetric molecular scaffolds with potential facial differentiation. Chemistry. 8:2002;2274-2278
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Chemistry
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Hennrich, G.1
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0345550459
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Approaches to the solid phase of a cyclotriveratrylene scaffold-based tripodal library as potential artificial receptors
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Chamorro C., Liskamp R.M.J. Approaches to the solid phase of a cyclotriveratrylene scaffold-based tripodal library as potential artificial receptors. J Comb Chem. 5:2003;794-801
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Biol-inspired synthetic receptor molecules towards mimicry of vancomycin
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Monnee M.C.F., Brouwer A.J., Verbeek L.M., Van Wageningen A.M.A., Liskamp R.M.J. Biol-inspired synthetic receptor molecules towards mimicry of vancomycin. Bioorg Med Chem Lett. 11:2001;1521-1525
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Monnee, M.C.F.1
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24
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0035512138
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A selectively deprotectable triazacyclo-phane scaffold for the construction of artificial receptors
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Opatz T., Liskamp R.M.J. A selectively deprotectable triazacyclo-phane scaffold for the construction of artificial receptors. Org Lett. 3:2001;3499-3502
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Synthesis and screening of libraries of synthetic tripodal receptor molecules with three different amino acid or peptide arms: Identification of iron binders
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3+ binders.
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Iorio E.J., Shao Y., Chen C.T., Wagner H., Still W.C. Sequence-selective peptide detection by small synthetic chemosensors selected from an encoded combinatorial chemosensor library. Bioorg Med Chem Lett. 11:2001;1635-1638
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Synthesis of calyx[4]arene library substituted with peptides at the upper rim
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A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides
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3+, using split-and-mix synthesis, orthogonal linkers with a two-step screening protocol, and a laddering procedure with encoded peptides caps to give a coding strand that was deconvoluted by MALDI MS.
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3+, using split-and-mix synthesis, orthogonal linkers with a two-step screening protocol, and a laddering procedure with encoded peptides caps to give a coding strand that was deconvoluted by MALDI MS.
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0037419786
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Differential receptors create patterns diagnostic for ATP and GTP
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An array of 'differential' receptors is created by randomly selecting beads from a split-and-mix library of tweezer receptors designed to bind nucleotide triphosphates. Binding of ATP or GTP can be distinguished by the pattern of responses from the different receptors in the array.
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McCleskey S.C., Griffin M.J., Schneider S.E., McDevitt J.T., Anslyn E.V. Differential receptors create patterns diagnostic for ATP and GTP. J Am Chem Soc. 125:2003;1114-1115 An array of 'differential' receptors is created by randomly selecting beads from a split-and-mix library of tweezer receptors designed to bind nucleotide triphosphates. Binding of ATP or GTP can be distinguished by the pattern of responses from the different receptors in the array.
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J Am Chem Soc
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Determination of binding affinities on solid supports: Influence of the loading and the nature of the solid support
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Conza M, Wennemers H: Determination of binding affinities on solid supports: influence of the loading and the nature of the solid support. Chem Commun 2003:866-867.
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Conza, M.1
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