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1
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0032087371
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Generation and screening of synthetic receptor libraries
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De Miguel YR, Sanders JKM: Generation and screening of synthetic receptor libraries. Curr Opin Chem Biol 1997, 2:417-421. This review contains a concise summary of combinatorial approaches to receptor design, focusing on the immediate years before publication (1995-1997).
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(1997)
Curr Opin Chem Biol
, vol.2
, pp. 417-421
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De Miguel, Y.R.1
Sanders, J.K.M.2
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2
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33748844784
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Combinatorial libraries: Studies in molecular recognition and the quest for new catalysts
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Gennari C, Nestler HP, Piarulli U, Salom B: Combinatorial libraries: Studies in molecular recognition and the quest for new catalysts. Liebigs Ann/Requeil 1997:637-647. This is a thorough review of early work (1990-1997) in combinatorial host-guest chemistry, tracing the development of libraries through small molecules, libraries of ligands and combinatorial receptors.
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(1997)
Liebigs Ann/Requeil
, pp. 637-647
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Gennari, C.1
Nestler, H.P.2
Piarulli, U.3
Salom, B.4
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3
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12644264317
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Synthesis and screening of small molecule libraries active in binding to DNA
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Shipps GW Jr, Pryor KE, Xian J, Skyler DA, Davidson EH, Rebek J Jr: Synthesis and screening of small molecule libraries active in binding to DNA. Proc Natl Acad Sci USA 1997, 94:11833-11838. As part of a continuing effort to create sizable small-molecule libraries through the functionalization of a structural core, a xanthene-based library is assayed for binding to DNA. The most active compounds are determined through deconvolution with smaller sublibraries.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 11833-11838
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Shipps G.W., Jr.1
Pryor, K.E.2
Xian, J.3
Skyler, D.A.4
Davidson, E.H.5
Rebek J., Jr.6
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4
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0031882497
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A mechanism-based, solution-phase method for screening combinatorial mixtures of potential platinum anticancer drugs
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Sandman KE, Fuhrmann P, Lippard SJ: A mechanism-based, solution-phase method for screening combinatorial mixtures of potential platinum anticancer drugs. J Biol Inorg Chem 1998, 3:74-80.
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(1998)
J Biol Inorg Chem
, vol.3
, pp. 74-80
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Sandman, K.E.1
Fuhrmann, P.2
Lippard, S.J.3
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5
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0032569212
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A library approach to the discovery of small molecules that recognize RNA: Use of a 1,3-hydroxyamine motif as core
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Wong C-H, Hendrix M, Manning DD, Rosenbohm C, Greenberg WA: A library approach to the discovery of small molecules that recognize RNA: Use of a 1,3-hydroxyamine motif as core. J Am Chem Soc 1998, 120:8319-8327. The 1,3-hydroxyamine motif previously shown to complex phosphodiesters is expanded by combinatorial derivatization of an aminoglucopyranoside core. Surface plasmon resonance was used to determine binding to several RNA molecules.
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(1998)
J Am Chem Soc
, vol.120
, pp. 8319-8327
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Wong, C.-H.1
Hendrix, M.2
Manning, D.D.3
Rosenbohm, C.4
Greenberg, W.A.5
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6
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0003042169
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Protein surface recognition by synthetic receptors: A route to novel submicromolar inhibitors for chymotrypsin
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Park HS, Lin Q, Hamilton AD: Protein surface recognition by synthetic receptors: A route to novel submicromolar inhibitors for chymotrypsin. J Am Chem Soc 1999, 121:8-13. Protein surface recognition was accomplished by a receptor with variant cyclic peptides attached to a calixarene core. Active molecules inhibit the action of chymotrypsin, presumably by binding near the active site and blocking substrate approach.
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(1999)
J Am Chem Soc
, vol.121
, pp. 8-13
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Park, H.S.1
Lin, Q.2
Hamilton, A.D.3
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7
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0032497349
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Higher order iminodiacetic acid libraries for probing protein-protein interactions
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Boger DL, Ducray P, Chai W, Jiang W, Goldberg J: Higher order iminodiacetic acid libraries for probing protein-protein interactions. Bioorg Med Chem Lett 1998, 8:2339-2344.
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(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 2339-2344
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Boger, D.L.1
Ducray, P.2
Chai, W.3
Jiang, W.4
Goldberg, J.5
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8
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0032514572
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The 'triamino-analogue' of methylcholates; a facial amphiphile and scaffold with potential for combinatorial and molecular recognition chemistry
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Broderick S, Davis AP, Williams RP: The 'triamino-analogue' of methylcholates; a facial amphiphile and scaffold with potential for combinatorial and molecular recognition chemistry. Tetrahedron Lett 1998, 39:6083-6086.
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(1998)
Tetrahedron Lett
, vol.39
, pp. 6083-6086
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Broderick, S.1
Davis, A.P.2
Williams, R.P.3
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9
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0032491014
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Natural products analogs as scaffolds for supramolecular and combinatorial chemistry
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Mink D, Mecozzi S, Rebek J Jr: Natural products analogs as scaffolds for supramolecular and combinatorial chemistry. Tetrahedron Lett 1998, 39:5709-5712.
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(1998)
Tetrahedron Lett
, vol.39
, pp. 5709-5712
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Mink, D.1
Mecozzi, S.2
Rebek J., Jr.3
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10
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0032537036
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The activated core approach to combinatorial chemistry: A selection of new core molecules
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Pryor KE, Shipps GW Jr, Skyler DA, Rebek J Jr: The activated core approach to combinatorial chemistry: A selection of new core molecules. Tetrahedron 1998, 54:4107-4124.
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(1998)
Tetrahedron
, vol.54
, pp. 4107-4124
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Pryor, K.E.1
Shipps G.W., Jr.2
Skyler, D.A.3
Rebek J., Jr.4
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11
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0039302822
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Tweezers with different bite: Increasing the affinity of synthetic receptors by varying the hinge part
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Lowik DWRM, Weingarten MD, Broekema M, Brouwer AJ, Still WC, Liskamp RMJ: Tweezers with different bite: Increasing the affinity of synthetic receptors by varying the hinge part. Angew Chem Int Ed Engl 1998, 37:1846-1850.
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(1998)
Angew Chem Int Ed Engl
, vol.37
, pp. 1846-1850
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Lowik, D.W.R.M.1
Weingarten, M.D.2
Broekema, M.3
Brouwer, A.J.4
Still, W.C.5
Liskamp, R.M.J.6
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12
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0001597672
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Simple structural requirements for sequence-selective peptide receptors? Tripeptide binding by a podand ionophore
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Burger M, Still WC: Simple structural requirements for sequence-selective peptide receptors? Tripeptide binding by a podand ionophore. J Org Chem 1997, 62:4785-4790.
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(1997)
J Org Chem
, vol.62
, pp. 4785-4790
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Burger, M.1
Still, W.C.2
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13
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0032488791
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Fluorescent, sequence-selective peptide detection by synthetic small molecules
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Chen C-T, Wagner H, Still WC: Fluorescent, sequence-selective peptide detection by synthetic small molecules. Science 1998, 279:851-853. An already elegant receptor design is improved by attaching fluorescent labels. Detection is accomplished by visual observation, as receptors will only fluoresce when bound to substrate.
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(1998)
Science
, vol.279
, pp. 851-853
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Chen, C.-T.1
Wagner, H.2
Still, W.C.3
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14
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0031764606
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Screening an inverted peptide library in water with a guanidinium-based tweezer receptor
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Davies M, Bonnat M, Guiller F, Kilburn JD, Bradley M: Screening an inverted peptide library in water with a guanidinium-based tweezer receptor. J Org Chem 1998, 63:8696-8703.
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(1998)
J Org Chem
, vol.63
, pp. 8696-8703
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Davies, M.1
Bonnat, M.2
Guiller, F.3
Kilburn, J.D.4
Bradley, M.5
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15
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0031455570
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Peptide-binding antibiotics: A solid-phase assay for screening libraries of vancomycin mimics for selective d-Ala-d-Ala binding
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Rothman JH, Still WC: Peptide-binding antibiotics: A solid-phase assay for screening libraries of vancomycin mimics for selective d-Ala-d-Ala binding. Bioorg Med Chem Lett 1997, 7:3159-3164.
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(1997)
Bioorg Med Chem Lett
, vol.7
, pp. 3159-3164
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Rothman, J.H.1
Still, W.C.2
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16
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0032516325
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Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry
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Patterson S, Smith BD, Taylor RE: Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry. Tetrahedron Lett 1998, 39:3111-3114.
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(1998)
Tetrahedron Lett
, vol.39
, pp. 3111-3114
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Patterson, S.1
Smith, B.D.2
Taylor, R.E.3
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17
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0032542266
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Investigation of the molecular recognition of amino acids by cyclopeptides with reflectometric interference spectroscopy
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Leipert D, Nopper D, Bauser M, Gaulitz G, Jung G: Investigation of the molecular recognition of amino acids by cyclopeptides with reflectometric interference spectroscopy. Angew Chem Int Ed Engl 1998, 37:3308-3311. Reflectometric interference spectroscopy was employed as a novel detection method to assay binding of amino acids to various cyclopeptides.
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(1998)
Angew Chem Int Ed Engl
, vol.37
, pp. 3308-3311
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Leipert, D.1
Nopper, D.2
Bauser, M.3
Gaulitz, G.4
Jung, G.5
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18
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0032500336
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Enantioselective resolving resins from a combinatorial library. Kinetic resolution of cyclic amino acid derivatives
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Weingarten MD, Sekanina K, Still WC: Enantioselective resolving resins from a combinatorial library. Kinetic resolution of cyclic amino acid derivatives. J Am Chem Soc 1998, 120:9112-9113. The most enantioselective receptors in a resin-bound library are detected through color visualization with dyed, racemic, solution-phase guests . Those that bind one enantiomer turn red, while those that bind the other turn blue.
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(1998)
J Am Chem Soc
, vol.120
, pp. 9112-9113
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Weingarten, M.D.1
Sekanina, K.2
Still, W.C.3
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19
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0032494970
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Combinatorial 'library on bead' approach to polymeric materials with vastly enhanced chiral recognition
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Murer P, Lewandowski K, Svec F, Fréchet JMJ: Combinatorial 'library on bead' approach to polymeric materials with vastly enhanced chiral recognition. Chem Commun 1998:2559-2560.
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(1998)
Chem Commun
, pp. 2559-2560
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Murer, P.1
Lewandowski, K.2
Svec, F.3
Fréchet, J.M.J.4
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20
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0001858454
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Highly selective chiral recognition on polymer supports: Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands
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Lewandowski K, Murer P, Svec F, Fréchet JMJ: Highly selective chiral recognition on polymer supports: Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands. Chem Commun 1998:2237-2238.
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(1998)
Chem Commun
, pp. 2237-2238
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Lewandowski, K.1
Murer, P.2
Svec, F.3
Fréchet, J.M.J.4
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21
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1542548456
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Chemical evolution: A model system that selects and amplifies a receptor for the tripeptide (D)Pro(L)Val(D)Val
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Hioki H, Still WC: Chemical evolution: A model system that selects and amplifies a receptor for the tripeptide (D)Pro(L)Val(D)Val. J Org Chem 1998, 63:904-905. A small dynamic library was formed by dimerization of cyclic tetraamides through a disulfide bond. The equilibrium mixture of dimers is shifted by addition of a guest that selectively binds one dimer.
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(1998)
J Org Chem
, vol.63
, pp. 904-905
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Hioki, H.1
Still, W.C.2
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22
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0001936051
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Libraries for receptor-assisted combinatorial synthesis (RACS). The olefin metathesis reaction
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Giger T, Wigger M, Audetat S, Benner SA: Libraries for receptor-assisted combinatorial synthesis (RACS). The olefin metathesis reaction. Synlett 1998:688-690.
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(1998)
Synlett
, pp. 688-690
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Giger, T.1
Wigger, M.2
Audetat, S.3
Benner, S.A.4
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23
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0031750811
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Use of molecular recognition to drive chemical evolution: Mechanisms of an automated genetic algorithm implementation
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Eliseev AV, Nelen MI: Use of molecular recognition to drive chemical evolution: Mechanisms of an automated genetic algorithm implementation. Chem Eur J 1998, 4:825-834.
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(1998)
Chem Eur J
, vol.4
, pp. 825-834
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Eliseev, A.V.1
Nelen, M.I.2
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24
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21844433981
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Libraries of non-covalent hydrogen-bonded assemblies; combinatorial synthesis of supramolecular systems
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Crego Calama M, Hulst R, Fokkens R, Nibbering NMM, Timmerman P, Reinhoudt DN: Libraries of non-covalent hydrogen-bonded assemblies; combinatorial synthesis of supramolecular systems. Chem Commun 1998:1021-1022. Libraries of hydrogen-bonded assemblies are formed through cyclic hexamers of melamine barbiturate. Differentially substituted monomers exist in a thermodynamic equilibrium of hexamers.
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(1998)
Chem Commun
, pp. 1021-1022
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Crego Calama, M.1
Hulst, R.2
Fokkens, R.3
Nibbering, N.M.M.4
Timmerman, P.5
Reinhoudt, D.N.6
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25
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0000765259
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Macrocycles derived from cinchona alkaloids: A thermodynamic vs kinetic study
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Rowan SJ, Sanders JKM: Macrocycles derived from cinchona alkaloids: A thermodynamic vs kinetic study. J Org Chem 1998, 63:1536-1546.
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(1998)
J Org Chem
, vol.63
, pp. 1536-1546
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Rowan, S.J.1
Sanders, J.K.M.2
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26
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0031732777
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High-throughput strategies for the discovery of catalysis
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Shimizu KD, Snapper ML, Hoveyda AH: High-throughput strategies for the discovery of catalysis. Chem Eur J 1998, 4:1885-1889.
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(1998)
Chem Eur J
, vol.4
, pp. 1885-1889
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Shimizu, K.D.1
Snapper, M.L.2
Hoveyda, A.H.3
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27
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0032546499
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High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal coplexes
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Berg T, Vandersteen AM, Janda KD: High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal coplexes. Bioorg Med Chem Lett 1998, 8:1221-1224.
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(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 1221-1224
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Berg, T.1
Vandersteen, A.M.2
Janda, K.D.3
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28
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0000684017
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Investigation of a family of chiral ligands for enantioselective catalysis via parallel synthesis and high-throughput screening
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Gennari C, Ceccarelli S, Piarulli U, Montalbetti CAGN, Jackson RFW: Investigation of a family of chiral ligands for enantioselective catalysis via parallel synthesis and high-throughput screening. J Org Chem 1998, 63:5312-5313.
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(1998)
J Org Chem
, vol.63
, pp. 5312-5313
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Gennari, C.1
Ceccarelli, S.2
Piarulli, U.3
Montalbetti, C.A.G.N.4
Jackson, R.F.W.5
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29
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0030807838
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Efficient catalysis of proton transfer by synzymes
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Hollfelder F, Kirby AJ, Tarfik AS: Efficient catalysis of proton transfer by synzymes. J Am Chem Soc 1997,119:9578-9579.
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(1997)
J Am Chem Soc
, vol.119
, pp. 9578-9579
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Hollfelder, F.1
Kirby, A.J.2
Tarfik, A.S.3
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30
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0001057603
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Combinatorial catalysis of an elimination reaction
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Menger FM, Ding J, Barragan V: Combinatorial catalysis of an elimination reaction. J Org Chem 1998, 63:7578-7579. Derivatization of a polymer with chemically active functional groups yielded a catalyst for an elimination reaction.
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(1998)
J Org Chem
, vol.63
, pp. 7578-7579
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Menger, F.M.1
Ding, J.2
Barragan, V.3
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