The melanocortin-1 receptor: Red hair and beyond

Archives of Dermatology

Volumn 137, Issue 11, 2001, Pages 1477-1485

  Schaffer, J V ^a   Bolognia, J L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; MELANIN; MELANOCORTIN 1 RECEPTOR; PROOPIOMELANOCORTIN;

AUTOSOMAL RECESSIVE INHERITANCE; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAIR COLOR; HUMAN; MELANOGENESIS; PHENOTYPE; PIGMENTATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; SKIN COLOR;

ANIMALS; HAIR COLOR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MELANOCYTE-STIMULATING HORMONES; MICE; POLYMORPHISM, GENETIC; PRO-OPIOMELANOCORTIN; PROTEINS; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; SKIN NEOPLASMS; SKIN PIGMENTATION;

EID: 0035160974     PISSN: 0003987X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

1. Risk factors for developing cutaneous melanoma and criteria for identifying persons at risk: Multicenter case-control study of the central malignant melanoma registry of the German Dermatological Society
2. The melanocortin 1 receptor (MCIR): More than just red hair
3. Biochemical control of melanogenesis and melanosomal organization
4. Hair melanins and hair color: Ultrastructural and biochemical aspects
5. Human pigmentation genetics: The difference is only skin deep
6. The genetics of pigmentation: From fancy genes to complex traits
7. Participation of the melanocortin-1 receptor in the UV control of pigmentation
8. Modulation of melanogenic protein expression during the switch from eu- to pheomelanogenesis
9. The pinkeyed-dilution protein and the eumelanin/pheomelanin switch: In support of a unifying hypothesis
10. Eumelanin and phaeomelanin contents of human epidermis and cultured melanocytes
11. Supranuclear melanin caps reduce ultraviolet induced DNA photoproducts in human epidermis
12. The melanocortin receptors: Agonists, antagonists, and the hormonal control of pigmentation
13. Melanocortin receptors, red hair, and skin cancer
14. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress
15. Brain melanocortin receptors: From cloning to function
16. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
17. Exocrine gland dysfunction in MC5-R-deficient mice: Evidence for coordinated regulation of exocrine gland function by melanocortin peptides
18. From agouti to POMC: 100 years of fat blonde mice
19. The cloning of a family of genes that encode the melanocortin receptors
20. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA
21. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides
22. Cyclic AMP a key messenger in the regulation of skin pigmentation
23. Activation of cAMP-dependent protein kinase is required for optimal α-melanocyte-stimulating hormone-induced pigmentation
24. Mapping of the gene encoding the melanocortin-1 receptor (MC1R) to human chromosome 16q24.3 by fluorescence in situ hybridization
25. The role of alpha-melanocyte-stimulating hormone in cutaneous biology
26. Anti-inflammatory actions of the neuroimmunomodulator α-MSH
27. Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis
28. The melanocortin-1 receptor and human pigmentation
29. 7 α-melanocyte-stimulating hormone increases the eumelanin:phaeomelanin ratio in cultured human melanocytes
30. Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: Evidence for a regulatory role of ultraviolet B, interleukin-1α, interleukin-1β, endothelin-1 and tumor necrosis factor-α
31. Proopiomelanocortin, its derived peptides, and the skin
32. A view of the N-acetylation of alpha-melanocyte-stimulating hormone and beta-endorphin from a phylogenetic perspective
33. α-MSH and the regulation of melanocyte function
34. A case of hyperpigmentation due to α-MSH hypersecretion
35. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
36. Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor
37. Production and release of proopiomelanocortin (POMC) derived peptide by human melanocytes and keratinocytes in culture: Regulation by ultraviolet B
38. Neprilysin, a novel target for ultraviolet B regulation of melanogenesis via melanocortins
39. UV light and MSH receptors
40. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
41. Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to α-melanotropin
42. Homologous pigmentation mutations in human, mouse, and other model organisms
43. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function
44. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
45. Unresponsiveness of human epidermal melanocytes to melanocyte-stimulating hormone and its association with red hair
46. Structure and function of ASP, the human homolog of the mouse agouti gene
47. Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans
48. Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair
49. Melanocortin 1 receptor variants in an Irish population
50. Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation
51. Melanocortin-1 receptor polymorphisms and risk of melanoma: Is the association explained solely by pigmentation phenotype?
52. Val92Met variant of the melanocyte stimulating hormone receptor gene
53. Identification of common polymorphisms in the coding sequence of the human MSH receptor (MC1R) with possible biological effects
54. Evidence for variable selective pressures at MC1R
55. High polymorphism at the human melanocortin 1 receptor locus
56. The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma
57. Susceptibility to melanoma: Influence of skin type and polymorphism in the melanocyte stimulating hormone receptor gene
58. Human pigmentation phenotype: A point mutation generates nonfunctional MSH receptor
59. Loss of function mutations of the human melanocortin 1 receptor are common and are associated with red hair
60. The melanocyte stimulating hormone receptor polymorphism: Association of the V92M and A294H alleles with basal cell carcinoma
61. Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma
62. Molecular basis of receptor/G-protein-coupling selectivity
63. Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair
64. Concerning the inheritance of red hair
65. Red hair colour as a genetical character
66. Characterization of the promoter region of the human melanocortin-1 receptor (MC1R) gene
67. Molecular analysis of a new splice variant of the human melanocortin-1 receptor
68. Skin type, melanoma, and melanocortin 1 receptor variants