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Volumn 427, Issue 2, 2004, Pages 143-153
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Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation
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Author keywords
Coumarin 7 hydroxylation; CYP2A13; CYP2A6; Cytochrome P450; Protein model; Site directed mutagenesis
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Indexed keywords
ALANINE;
ARGININE;
COUMARIN 7 HYDROXYLASE;
CYTOCHROME P450 2A;
CYTOCHROME P450 2A13;
CYTOCHROME P450 2A6;
CYTOCHROME P450 ISOENZYME;
HISTIDINE;
UNCLASSIFIED DRUG;
VALINE;
7-HYDROXYCOUMARIN;
COUMARIN;
COUMARIN 7-HYDROXYLASE;
COUMARIN DERIVATIVE;
CYP2A13 PROTEIN, HUMAN;
MIXED FUNCTION OXIDASE;
UMBELLIFERONE;
UMBELLIFERONE DERIVATIVE;
UNSPECIFIC MONOOXYGENASE;
AMINO ACID SUBSTITUTION;
ARTICLE;
CATALYSIS;
CRYSTAL STRUCTURE;
ENZYME ACTIVE SITE;
ENZYME ACTIVITY;
ENZYME KINETICS;
ENZYME SUBSTRATE;
ENZYME SUBSTRATE COMPLEX;
HYDROXYLATION;
NUCLEOTIDE SEQUENCE;
PRIORITY JOURNAL;
PROTEIN ANALYSIS;
PROTEIN EXPRESSION;
PROTEIN LOCALIZATION;
SITE DIRECTED MUTAGENESIS;
STRUCTURAL HOMOLOGY;
WILD TYPE;
AMINO ACID SEQUENCE;
BINDING SITE;
CHEMICAL MODEL;
CHEMICAL STRUCTURE;
CHEMISTRY;
COMPARATIVE STUDY;
COMPUTER SIMULATION;
ENZYME ACTIVATION;
EVALUATION;
MOLECULAR GENETICS;
PROTEIN BINDING;
PROTEIN CONFORMATION;
SEQUENCE HOMOLOGY;
STRUCTURE ACTIVITY RELATION;
NICOTIANA TABACUM;
AMINO ACID SEQUENCE;
AMINO ACID SUBSTITUTION;
ARGININE;
ARYL HYDROCARBON HYDROXYLASES;
BINDING SITES;
COMPUTER SIMULATION;
COUMARINS;
ENZYME ACTIVATION;
HYDROXYLATION;
MIXED FUNCTION OXYGENASES;
MODELS, CHEMICAL;
MODELS, MOLECULAR;
MOLECULAR SEQUENCE DATA;
MUTAGENESIS, SITE-DIRECTED;
PROTEIN BINDING;
PROTEIN CONFORMATION;
SEQUENCE HOMOLOGY, AMINO ACID;
STRUCTURE-ACTIVITY RELATIONSHIP;
UMBELLIFERONES;
VALINE;
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EID: 2942605963
PISSN: 00039861
EISSN: None
Source Type: Journal
DOI: 10.1016/j.abb.2004.03.016 Document Type: Article |
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Times cited : (53)
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References (34)
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