NXF-2, REF-1, and REF-2 affect the choice of nuclear export pathway for tra-2 mRNA in C. elegans

Molecular Cell

Volumn 14, Issue 5, 2004, Pages 599-610

  Kuersten, Scott ^a   Segal, Scott P ^a,b   Verheyden, Jamie ^a   LaMartina, Sarah M ^a   Goodwin, Elizabeth B ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN; PROTEIN NXF 2; REDOX EFFECTOR FACTOR 1; REDOX EFFECTOR FACTOR 2; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CELL NUCLEUS; CELL TRANSPORT; CONTROLLED STUDY; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REPORTER GENE; RNA TRANSLATION; SEXUAL DEVELOPMENT; TRANSGENE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL NUCLEUS; CYTOPLASM; KARYOPHERINS; MEMBRANE PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PROTEIN BIOSYNTHESIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS;

CAENORHABDITIS; CAENORHABDITIS ELEGANS;

EID: 2942582453     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2004.05.004     Document Type: Article

References (35)

1. Bachi A., Braun I.C., Rodrigues J.P., Pante N., Ribbeck K., von Kobbe C., Kutay U., Wilm M., Gorlich D., Carmo-Fonseca M., et al. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. RNA. 6:2000;136-158
2. Braun I.C., Rohrbach E., Schmitt C., Izaurralde E. TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus. EMBO J. 18:1999;1953-1965
3. Braun I.C., Herold A., Rode M., Izaurralde E. Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15. Mol. Cell. Biol. 22:2002;5405-5418
4. Brennan C.M., Gallouzi I.E., Steitz J.A. Protein ligands to HuR modulate its interaction with target mRNAs in vivo. J. Cell Biol. 151:2000;1-14
5. Brenner S. The genetics of Caenorhabditis elegans. Genetics. 77:1974;71-94
6. Englmeier L., Olivo J.C., Mattaj I.W. Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis. Curr. Biol. 9:1999;30-41
7. Fornerod M., Ohno M., Yoshida M., Mattaj I.W. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell. 90:1997;1051-1060
8. Gallouzi I.E., Brennan C.M., Steitz J.A. Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock. RNA. 7:2001;1348-1361
9. Gatfield D., Izaurralde E. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J. Cell Biol. 159:2002;579-588
10. Gilbert W., Guthrie C. The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA. Mol. Cell. 13:2004;201-212
11. Goodwin E.B., Okkema P.G., Evans T.C., Kimble J. Translational regulation of tra-2 by its 3′ untranslated region controls sexual identity in C. elegans. Cell. 75:1993;329-339
12. Goodwin E.B., Hofstra K., Hurney C.A., Mango S., Kimble J. A genetic pathway for regulation of tra-2 translation. Development. 124:1997;749-758
13. Graves L.E., Segal S., Goodwin E.B. TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans. Nature. 399:1999;802-805
14. Herold A., Suyama M., Rodrigues J.P., Braun I.C., Kutay U., Carmo-Fonseca M., Bork P., Izaurralde E. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Mol. Cell. Biol. 20:2000;8996-9008
15. Hodgkin J. A genetic analysis of the sex-determining gene, tra-1, in the nematode Caenorhabditis elegans. Genes Dev. 1:1987;731-745
16. Huang Y., Gattoni R., Stevenin J., Steitz J.A. SR splicing factors serve as adapter proteins for TAP-dependent mRNA export. Mol. Cell. 11:2003;837-843
17. Jan E., Motzny C.K., Graves L.E., Goodwin E.B. The STAR protein, GLD-1, is a translational regulator of sexual identity in Caenorhabditis elegans. EMBO J. 18:1999;258-269
18. Kang Y., Bogerd H.P., Yang J., Cullen B.R. Analysis of the RNA binding specificity of the human tap protein, a constitutive transport element-specific nuclear RNA export factor. Virology. 262:1999;200-209
19. Katahira J., Strasser K., Podtelejnikov A., Mann M., Jung J.U., Hurt E. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J. 18:1999;2593-2609
20. Kuersten S., Arts G.J., Walther T.C., Englmeier L., Mattaj I.W. Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. Mol. Cell. Biol. 22:2002;5708-5720
21. Kuwabara P.E., Kimble J. Molecular genetics of sex determination in C. elegans. Trends Genet. 8:1992;164-168
22. Le Hir H., Gatfield D., Izaurralde E., Moore M.J. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J. 20:2001;4987-4997
23. Longman D., Johnstone I.L., Caceres J.F. The Ref/Aly proteins are dispensable for mRNA export and development in Caenorhabditis elegans. RNA. 9:2003;881-891
24. Lu S., Cullen B.R. Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells. RNA. 9:2003;618-630
25. MacMorris M., Brocker C., Blumenthal T. UAP56 levels affect viability and mRNA export in Caenorhabditis elegans. RNA. 9:2003;847-857
26. Matsumoto K., Wassarman K.M., Wolffe A.P. Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA. EMBO J. 17:1998;2107-2121
27. Nott A., Meislin S.H., Moore M.J. A quantitative analysis of intron effects on mammalian gene expression. RNA. 9:2003;607-617
28. Ohno M., Segref A., Bachi A., Wilm M., Mattaj I.W. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell. 101:2000;187-198
29. Segal S., Graves L.E., Verheyden J., Goodwin E.B. RNA-regulated TRA-1 nuclear export controls sexual fates. Dev. Cell. 1:2001;539-551
30. Stutz F., Bachi A., Doerks T., Braun I.C., Seraphin B., Wilm M., Bork P., Izaurralde E. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA. 6:2000;638-650
31. Suyama M., Doerks T., Braun I.C., Sattler M., Izaurralde E., Bork P. Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins. EMBO Rep. 1:2000;53-58
32. Tan W., Zolotukhin A.S., Bear J., Patenaude D.J., Felber B.K. The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p. RNA. 6:2000;1762-1772
33. Vernet C., Artzt K. STAR, a gene family involved in signal transduction and activation of RNA. Trends Genet. 13:1997;479-484
34. Yang J., Bogerd H.P., Wang P.J., Page D.C., Cullen B.R. Two closely related human nuclear export factors utilize entirely distinct export pathways. Mol. Cell. 8:2001;397-406
35. Zarkower D., Hodgkin J. Molecular analysis of the C. elegans sex-determining gene tra-1. a gene encoding two zinc finger proteins Cell. 70:1992;237-249