Inhibition of NF-κB renders human juvenile costal chondrocyte cell lines sensitive to TNF-α-mediated cell death

Rheumatology International

Volumn 26, Issue 3, 2006, Pages 201-208

  Ho, Sung Yoon ^a   Kim, Hyun Ah ^b   Yeong, Wook Song ^c  

^a Hallym University   (South Korea)

^b Hallym University Sacred Heart Hospital   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Apoptosis; Chondrocyte; NF B; TNF

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENOVIRUS VECTOR; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3 INHIBITOR; CASPASE 8 INHIBITOR; CASPASE 9 INHIBITOR; CASPASE INHIBITOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BCL 2; PROTEIN BCL XL; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; X LINKED INHIBITOR OF APOPTOSIS; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)IMIDAZOLE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; MORPHOLINE DERIVATIVE; PYRIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CARTILAGE CELL; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ADENOVIRUS; APOPTOSIS; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSDUCTION; METABOLISM; PHYSIOLOGY; VIROLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; APOPTOSIS; CELL LINE; CHONDROCYTES; CHROMONES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; TRANSDUCTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 29244479198     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-004-0562-x     Document Type: Article

References (29)

1. Kim HA, Song YW (1999) Apoptotic chondrocyte death in rheumatoid arthritis. Arthritis Rheum 42:1528-1515
2. Blanco FJ, Guitian R, Vazquez-Martul E, de Toro FK, Galdo F (1998) Osteoarthritis chondrocytes die by apoptosis: a possible pathway for osteoarthritis pathology. Arthritis Rheum 41:284-289
3. Van Antwerp DJ, Martin SJ, Kafri K, Green DR, Verma IM (1996) Suppression of TNF-α-induced apoptosis by NF-κB. Science 274:787-789
4. Baker SJ, Reddy EP (1998) Modulation of life and death by the TNF receptor superfamily. Oncogene 17:3261-3270
5. Westacott CI, Atkins RM, Dieppe PA, Elson CJ (1994) Tumor necrosis factor-alpha receptor expression on chondrocytes isolated from human articular cartilage. J Rheumatol 21:1710-1715
6. Yoon YM, Kim SJ, Oh CD, Ju JW, Song WK, Yoo YJ, Huh TL, Chun JS (2002) Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase. J Biol Chem 277:8412-84207
7. Kim HA, Song YW (2002) TNF-alpha-mediated apoptosis in chondrocytes sensitized by MG132 or actinomycin D. Biochem Biophys Res Commun 295:937-944
8. Kim JY, Lee S, Hwangbo B, Lee CT, Kim YW, Han SK, Shim YS, Yoo CG (2000) NF-κB activation is related to the resistance of lung cancer cells to TNF-alpha-induced apoptosis. Biochem Biophys Res Commun 273:140-146
9. Schreiber E, Matthias P, Muller MM, Schaffner W (1989) Rapid detection of octamer binding proteins with 'mini-extracts' prepared from a small number of cells. Nucleic Acids Res 17:6419
10. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A, Brenner DA, Czaja MJ (1998) NF-κB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Am J Physiol 275:C1058-C1066
11. Kuhn K, Lotz M (2001) Regulation of CD95 (Fas/APO-1)-induced apoptosis in human chondrocytes. Arthritis Rheum 44:1644-1653
12. Kim HA, Song YS (2003) Facilitation of Fas-mediated apoptosis of human chondrocytes by the proteasome inhibitor and actinomycin D. J Rheumatol 30:550-558
13. Vercammen D, Beyaert R, Denecker G, Goossens V, Van Loo G, Declercq W, Grooten J, Fiers W, Vandenabeele P (1998) Inhibition of caspases increases the sensitivity of L292 cells to necrosis mediated by tumor necrosis factor. J Exp Med 187:1477-1485
14. Hsu H, Shu HB, Pan MG, Goeddel DV (1996) TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84:299-308
15. Liu ZG, Hsu H, Goeddel DV, Karin M (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87:565-576
16. Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS Jr (1998) NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and C-1AP2 to suppress caspase-8 activation. Science 281:1680-1683
17. Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF (1998) IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival. Science 281:998-1001
18. L. Mol Cell Biol 20:2687-2695
19. Heckman CA, Mehew JW, Boxer LM (2002) NF-κB activates Bcl-2 expression in t(14;18) lymphoma cells. Oncogene 21:3898-3908
20. Mitsiades N, Mitsiades CS, Poulaki V, Chauhan D, Richardson PG, Hideshima T, Munshi N, Treon SP, Anderson KC (2002) Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications. Blood 99:4079-4086
21. Hirahashi J, Takayanagi A, Hishikawa K, Takase O, Chikaraishi A, Hayashi M, Shimizu N, Saruta T (2000) Overexpression of truncated IκB alpha potentiates TNF-alpha-induced apoptosis in mesangial cells. Kidney Int 57:959-968
22. de Moissac D, Mustapha S, Greenberg AH, Kirshenbaum LA (1998) Bcl-2 activates the transcription factor NF-κB through the degradation of the cytoplasmic inhibitor IκB alpha. J Biol Chem 273:23946-23951
23. Liu H, Lo CR, Czaja MJ (2002) NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun. Hepatology 35:772-778
24. Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A (2001) Inhibition of JNK activation through NF-κB target genes. Nature 414:313-317
25. Shakibaei M, Schulze-Tanzil G, de Souza P, John T, Rahmanzadeh M, Rahmanzadeh R, Merker HJ (2001) Inhibition of mitogen-activated protein kinase kinase induces apoptosis of human chondrocytes. J Biol Chem 276:13289-13294
26. Pelletier JP, Fernandes JC, Jovanovic DV, Reboul P, Martel-Pelletier J (2001) Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase. J Rheumatol 28:2509-2519
27. Osawa Y, Banno Y, Nagaki M, Brenner DA, Naiki T, Nozawa Y, Nakashima S, Moriwaki H (2001) TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J Immunol 167:173-180
28. Relic B, Bentires-Alj M, Ribbens C, Franchimont N, Guerne PA, Benoit V, Merville MP, Bours V, Malaise MG (2002) TNF-alpha protects human primary articular chondrocytes from nitric oxide-induced apoptosis via nuclear factor-kappaB. Lab Invest 82:1661-1672
29. Eguchi J, Koshino T, Takagi T, Hayashi T, Saito T (2002) NF-κappa B and I-kappa B overexpression in articular chondrocytes with progression of type II collagen-induced arthritis in DBA/1 mouse knees. Clin Exp Rheumatol 20:647-652