Processing of α4 integrin by the proprotein convertases: Histidine at position P6 regulates cleavage

Biochemical Journal

Volumn 373, Issue 2, 2003, Pages 475-484

  Bergeron, Eric ^a   Basak, Ajoy ^b   Decroly, Etienne ^a,c   Seidah, Nabil G ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c INSERM   (France)

Author keywords

1 antitrypsin Portland ( 1 PDX); Furin; Integrin; PC5A; pH; Precursor processing

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; CELLS;

PROPROTEIN CONVERTASES (PC);

PROTEINS;

ALPHA4 INTEGRIN; AMMONIUM CHLORIDE; ENZYME; FURIN; HISTIDINE; PROPROTEIN CONVERTASE; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; ALPHA 1 ANTITRYPSIN; AMINO ACID; PRIMER DNA; PROPROTEIN CONVERTASE 5; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SUBTILISIN;

ACIDITY; AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CHO CELL; COLON CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROCESSING; WILD TYPE; ANIMAL; CELL ADHESION; CELL CULTURE; CHEMISTRY; COLON TUMOR; COMPARATIVE STUDY; GENETIC TRANSFECTION; HAMSTER; METABOLISM; MUTATION; NORTHERN BLOTTING; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERODIAGNOSIS; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

ALPHA 1-ANTITRYPSIN; AMINO ACIDS; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL ADHESION; CHO CELLS; COLONIC NEOPLASMS; CRICETINAE; DNA PRIMERS; FURIN; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; INTEGRIN ALPHA4; MUTAGENESIS, SITE-DIRECTED; MUTATION; PRECIPITIN TESTS; PROPROTEIN CONVERTASE 5; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SUBTILISINS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0041344533     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021630     Document Type: Article

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