Impact of inhibition of Qo site of mitochondrial complex III with myxothiazol on persistent sodium currents via superoxide and protein kinase C in rat hippocampal CA1 cells

Neurobiology of Disease

Volumn 21, Issue 1, 2006, Pages 206-216

  Lai, Bin ^a   Zhang, Li ^a   Dong, Lian Yan ^a   Zhu, Yan Hua ^a   Sun, Feng Yan ^a   Zheng, Ping ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Hippocampus; Mitochondrial; Myxothiazol; Neuron excitability; Persistent sodium currents; Protein kinase C; Qo site of complex III; Superoxide; Transient sodium currents; Whole cell patch clamp

Indexed keywords

HYDROXYL GROUP; MYXOTHIAZOL; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SCAVENGER; SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ALKALOID; ANTIFUNGAL AGENT; BENZOPHENANTHRIDINE DERIVATIVE; CHELERYTHRINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DRUG DERIVATIVE; ENZYME INHIBITOR; GLYCINE; HYDROXYL RADICAL; ISOQUINOLINE DERIVATIVE; MANGANESE(III) TETRAKIS(4 BENZOIC ACID)PORPHYRIN; MANGANESE(III)-TETRAKIS(4-BENZOIC ACID)PORPHYRIN; METALLOPORPHYRIN; METHACRYLIC ACID DERIVATIVE; N (2 MERCAPTOPROPRIONYL) GLYCINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N-(2-MERCAPTOPROPRIONYL)-GLYCINE; PHENANTHRIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SODIUM; SULFONAMIDE; THIAZOLE DERIVATIVE; THIOL DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HIPPOCAMPUS; HYPOXIA; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CURRENT; ANIMAL; BRAIN HYPOXIA; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MITOCHONDRION; PATCH CLAMP; PHYSIOLOGY; PYRAMIDAL NERVE CELL; SPRAGUE DAWLEY RAT;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ALKALOIDS; ANIMALS; ANTIBIOTICS, ANTIFUNGAL; BENZOPHENANTHRIDINES; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX III; ENZYME ACTIVATION; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GLYCINE; HIPPOCAMPUS; HYDROXYL RADICAL; HYPOXIA, BRAIN; ISOQUINOLINES; METALLOPORPHYRINS; METHACRYLATES; MITOCHONDRIA; PATCH-CLAMP TECHNIQUES; PHENANTHRIDINES; PROTEIN KINASE C; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; SULFHYDRYL COMPOUNDS; SULFONAMIDES; SUPEROXIDES; THIAZOLES;

EID: 29144535673     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.07.001     Document Type: Article

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