Immunosuppressive effect of a new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats

Transplant Immunology

Volumn 4, Issue 3, 1996, Pages 252-255

  Suzuki, Seiichi ^a   Enosawa, Shin ^a   Kakefuda, Toshihiro ^a   Li, Xiao Kang ^a   Mitsusada, Makoto ^a   Takahara, Shiro ^b   Amemiya, Hiroshi ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; NEW DRUG; TACROLIMUS;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GRAFT SURVIVAL; HEART GRAFT; LYMPHOCYTE CULTURE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030248747     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-3274(96)80026-8     Document Type: Article

References (17)

1. 1 Suzuki S, Hijioka T, Sakakibara I, Amemiya H. The synergistic effect of cyclosporine and mizoribine on heterotopic heart and partial-lung transplantation in rats. Transplantation 1987; 43: 743-44.
2. 2 Amemiya H, Suzuki S, Niiya S, Watanabe H, Kotake T. Syrtergistic effect of cyclosporine and mizoribine on survival of dog renal ailografts. Transplantation 1988; 46: 768-71.
3. 3 Suzuki S. Deoxyspergualin. Mode of action and clinical trials. Ann NY Acad Sci 1993; 696: 263-69.
4. 4 Suzuki S. FK506 and deoxyspergualin: experimental studies and clinical applications. Transplant Immunol 1994; 2: 190-98.
5. 5 Suzuki S. Deoxyspergualin: mode of action and effects on graft rejection. In: Thomson AW, Starzl TE eds. Immunosuppressive drugs. Development in anti-rejection therapy. London: Edward Arnold, 1994: 187-202.
6. 6 Suzuki S, Kanashiro M, Amemiya H. Effect of a new immunosuppressant, 15-deoxyspergualin, on heterotopic rat heart transplantation, in comparison with cyclosporine. Transplantation 1987; 44: 483-87.
7. 31P nuclear magnetic resonance spectrography, and its effect on rat heart transplantation. Transplantation 1988; 46: 669-72.
8. 8 Suzuki S, Enosawa S, Kakefuda T et al. A novel immunosuppressant, FTY720, having an unique mechanism of action induces long-term graft acceptance in rat and dog allotransplantation. Transplantation 1996; 61: 200-205.
9. 9 Fujita T, Inoue K, Yamamoto S et al. Fungal metabolites. Part II. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot (Tokyo) 1994; 47: 208-15.
10. 10 Takahashi N, Hayano T, Suzuki M. Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature 1983; 337: 473-75.
11. 11 Handschumacher RE, Harding NW, Drugge RJ. Cyclophilin: a specific cytosolic binding protein for cyclosporine A. Science 1984; 226: 544-47.
12. 12 Siekierka JJ, Hung HY, Poe M, Lin CS, Sigal NH. A cytosolic binding protein for the immunosuppressant FK506 has peptidylprolyl isomerase activity but is distinct from cyclophilin. Nature 1989; 341: 755-57.
13. 13 Harding MW, Galat A, Uehling DE, Schreiber SL. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature 1989; 341: 758-60.
14. 14 Suzuki S, Enosawa S, Kakefuda T, Amemiya H, Hoshino Y, Chiba K. Long-term graft acceptance in allografted rats and dogs by treatment with novel immunosuppressant, FTY720. Transplant Proc 1996; 28: 1325-26.
15. 31P nuclear magnetic resonance findings on heterotopically allografted hearts in rats treated with a novel immunosuppressant, FK506. Heart Vessels 1990; 5: 224-29.
16. 16 White DJG, Nagao T, Davies HFS. Experimental transplantation in small animals. In: White DJG ed. Cyclosporin A, Proceedings International Conference on CsA. Amsterdam: Elsevier, 1981: 89-100.
17. 17 Ochiai T, Nakajima K, Nagata M, Hori S, Asano T, Isono K. Studies of the induction and maintenance of long-term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats. Transplantation 1987; 44: 734-38.