-
3
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
R. Medzhitov, P. Preston-Hurlburt, and C.A. Janeway Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature 388 1997 394 397
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway Jr., C.A.3
-
4
-
-
0034933019
-
Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells
-
A. Krug, S. Rothenfusser, V. Hornung, B. Jahrsdorfer, S. Blackwell, Z.K. Ballas, S. Endres, A.M. Krieg, and G. Hartmann Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells Eur. J. Immunol. 31 2001 2154 2163
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 2154-2163
-
-
Krug, A.1
Rothenfusser, S.2
Hornung, V.3
Jahrsdorfer, B.4
Blackwell, S.5
Ballas, Z.K.6
Endres, S.7
Krieg, A.M.8
Hartmann, G.9
-
5
-
-
0035865054
-
Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs
-
D. Verthelyi, K.J. Ishii, M. Gursel, F. Takeshita, and D.M. Klinman Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs J. Immunol. 166 2001 2372 2377
-
(2001)
J. Immunol.
, vol.166
, pp. 2372-2377
-
-
Verthelyi, D.1
Ishii, K.J.2
Gursel, M.3
Takeshita, F.4
Klinman, D.M.5
-
6
-
-
17844380477
-
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
-
K. Honda, Y. Ohba, H. Yanai, H. Negishi, T. Mizutani, A. Takaoka, C. Taya, and T. Taniguchi Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction Nature 434 2005 1035 1040
-
(2005)
Nature
, vol.434
, pp. 1035-1040
-
-
Honda, K.1
Ohba, Y.2
Yanai, H.3
Negishi, H.4
Mizutani, T.5
Takaoka, A.6
Taya, C.7
Taniguchi, T.8
-
7
-
-
10744219675
-
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
-
E. Latz, A. Schoenemeyer, A. Visintin, K.A. Fitzgerald, B.G. Monks, C.F. Knetter, E. Lien, N.J. Nilsen, T. Espevik, and D.T. Golenbock TLR9 signals after translocating from the ER to CpG DNA in the lysosome Nat. Immunol. 5 2004 190 198
-
(2004)
Nat. Immunol.
, vol.5
, pp. 190-198
-
-
Latz, E.1
Schoenemeyer, A.2
Visintin, A.3
Fitzgerald, K.A.4
Monks, B.G.5
Knetter, C.F.6
Lien, E.7
Nilsen, N.J.8
Espevik, T.9
Golenbock, D.T.10
-
8
-
-
3142697714
-
TLR9 is localized in the endoplasmic reticulum prior to stimulation
-
C.A. Leifer, M.N. Kennedy, A. Mazzoni, C. Lee, M.J. Kruhlak, and D.M. Segal TLR9 is localized in the endoplasmic reticulum prior to stimulation J. Immunol. 173 2004 1179 1183
-
(2004)
J. Immunol.
, vol.173
, pp. 1179-1183
-
-
Leifer, C.A.1
Kennedy, M.N.2
Mazzoni, A.3
Lee, C.4
Kruhlak, M.J.5
Segal, D.M.6
-
9
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
-
A. Poltorak, X. He, I. Smirnova, M.Y. Liu, C.V. Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, and B. Beutler Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 1998 2085 2088
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.Y.4
Huffel, C.V.5
Du, X.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Galanos, C.10
Freudenberg, M.11
Ricciardi-Castagnoli, P.12
Layton, B.13
Beutler, B.14
-
10
-
-
0345561540
-
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
-
S.T. Qureshi, L. Lariviere, G. Leveque, S. Clermont, K.J. Moore, P. Gros, and D. Malo Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J. Exp. Med. 189 1999 615 625
-
(1999)
J. Exp. Med.
, vol.189
, pp. 615-625
-
-
Qureshi, S.T.1
Lariviere, L.2
Leveque, G.3
Clermont, S.4
Moore, K.J.5
Gros, P.6
Malo, D.7
-
11
-
-
0033120081
-
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
-
K. Hoshino, O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product J. Immunol. 162 1999 3749 3752
-
(1999)
J. Immunol.
, vol.162
, pp. 3749-3752
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
Sanjo, H.4
Ogawa, T.5
Takeda, Y.6
Takeda, K.7
Akira, S.8
-
12
-
-
0033574415
-
Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
-
J.C. Chow, D.W. Young, D.T. Golenbock, W.J. Christ, and F. Gusovsky Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction J. Biol. Chem. 274 1999 10689 10692
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 10689-10692
-
-
Chow, J.C.1
Young, D.W.2
Golenbock, D.T.3
Christ, W.J.4
Gusovsky, F.5
-
13
-
-
0033532629
-
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
-
R. Shimazu, S. Akashi, H. Ogata, Y. Nagai, K. Fukudome, K. Miyake, and M. Kimoto MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4 J. Exp. Med. 189 1999 1777 1782
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1777-1782
-
-
Shimazu, R.1
Akashi, S.2
Ogata, H.3
Nagai, Y.4
Fukudome, K.5
Miyake, K.6
Kimoto, M.7
-
14
-
-
0036301797
-
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
-
Y. Nagai, S. Akashi, M. Nagafuku, M. Ogata, Y. Iwakura, S. Akira, T. Kitamura, A. Kosugi, M. Kimoto, and K. Miyake Essential role of MD-2 in LPS responsiveness and TLR4 distribution Nat. Immunol. 3 2002 667 672
-
(2002)
Nat. Immunol.
, vol.3
, pp. 667-672
-
-
Nagai, Y.1
Akashi, S.2
Nagafuku, M.3
Ogata, M.4
Iwakura, Y.5
Akira, S.6
Kitamura, T.7
Kosugi, A.8
Kimoto, M.9
Miyake, K.10
-
15
-
-
0035796406
-
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling
-
A.B. Schromm, E. Lien, P. Henneke, J.C. Chow, A. Yoshimura, H. Heine, E. Latz, B.G. Monks, D.A. Schwartz, K. Miyake, and D.T. Golenbock Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling J. Exp. Med. 194 2001 79 88
-
(2001)
J. Exp. Med.
, vol.194
, pp. 79-88
-
-
Schromm, A.B.1
Lien, E.2
Henneke, P.3
Chow, J.C.4
Yoshimura, A.5
Heine, H.6
Latz, E.7
Monks, B.G.8
Schwartz, D.A.9
Miyake, K.10
Golenbock, D.T.11
-
16
-
-
0034460240
-
Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1
-
K. Miyake, H. Ogata, Y. Nagai, S. Akashi, and M. Kimoto Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1 J. Endotoxin. Res. 6 2000 389 391
-
(2000)
J. Endotoxin. Res.
, vol.6
, pp. 389-391
-
-
Miyake, K.1
Ogata, H.2
Nagai, Y.3
Akashi, S.4
Kimoto, M.5
-
17
-
-
0141890200
-
Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: Higher affinity than that with MD-2 or CD14
-
S. Akashi, S.-I. Saitoh, Y. Wakabayashi, T. Kikuchi, N. Takamura, Y. Nagai, Y. Kusumoto, K. Fukase, S. Kusumoto, Y. Adachi, A. Kosugi, and K. Miyake Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14 J. Exp. Med. 198 2003 1035 1042
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1035-1042
-
-
Akashi, S.1
Saitoh, S.-I.2
Wakabayashi, Y.3
Kikuchi, T.4
Takamura, N.5
Nagai, Y.6
Kusumoto, Y.7
Fukase, K.8
Kusumoto, S.9
Adachi, Y.10
Kosugi, A.11
Miyake, K.12
-
18
-
-
0142157000
-
Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells
-
M.W. Hornef, B.H. Normark, A. Vandewalle, and S. Normark Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells J. Exp. Med. 198 2003 1225 1235
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1225-1235
-
-
Hornef, M.W.1
Normark, B.H.2
Vandewalle, A.3
Normark, S.4
-
19
-
-
0037033073
-
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction
-
E. Latz, A. Visintin, E. Lien, K.A. Fitzgerald, B.G. Monks, E.A. Kurt-Jones, D.T. Golenbock, and T. Espevik Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction J. Biol. Chem. 277 2002 47834 47843
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 47834-47843
-
-
Latz, E.1
Visintin, A.2
Lien, E.3
Fitzgerald, K.A.4
Monks, B.G.5
Kurt-Jones, E.A.6
Golenbock, D.T.7
Espevik, T.8
-
20
-
-
0034795208
-
Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability
-
F. Randow, and B. Seed Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability Nat. Cell Biol. 3 2001 891 896
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 891-896
-
-
Randow, F.1
Seed, B.2
-
21
-
-
0037619127
-
MD-2 is necessary for the Toll-Like receptor 4 protein to undergo glycosylation essential for its translocation to the cell surface
-
T. Ohnishi, M. Muroi, and K. Tanamoto MD-2 is necessary for the Toll-Like receptor 4 protein to undergo glycosylation essential for its translocation to the cell surface Clin. Diagn. Lab. Immunol. 10 2003 405 410
-
(2003)
Clin. Diagn. Lab. Immunol.
, vol.10
, pp. 405-410
-
-
Ohnishi, T.1
Muroi, M.2
Tanamoto, K.3
-
22
-
-
3242708716
-
Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2
-
H.P. Jia, J.N. Kline, A. Penisten, M.A. Apicella, T.L. Gioannini, J. Weiss, and P.B. McCray Jr. Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2 Am. J. Physiol. Lung Cell. Mol. Physiol. 287 2004 L428 L437
-
(2004)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.287
-
-
Jia, H.P.1
Kline, J.N.2
Penisten, A.3
Apicella, M.A.4
Gioannini, T.L.5
Weiss, J.6
McCray Jr., P.B.7
-
23
-
-
1642529500
-
Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations
-
T.L. Gioannini, A. Teghanemt, D. Zhang, N.P. Coussens, W. Dockstader, S. Ramaswamy, and J.P. Weiss Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations Proc. Natl. Acad. Sci. USA 101 2004 4186 4191
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4186-4191
-
-
Gioannini, T.L.1
Teghanemt, A.2
Zhang, D.3
Coussens, N.P.4
Dockstader, W.5
Ramaswamy, S.6
Weiss, J.P.7
-
24
-
-
4544250809
-
A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4
-
M.N. Kennedy, G.E. Mullen, C.A. Leifer, C. Lee, A. Mazzoni, K.N. Dileepan, and D.M. Segal A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4 J. Biol. Chem. 279 2004 34698 34704
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 34698-34704
-
-
Kennedy, M.N.1
Mullen, G.E.2
Leifer, C.A.3
Lee, C.4
Mazzoni, A.5
Dileepan, K.N.6
Segal, D.M.7
-
25
-
-
29044444407
-
-
submitted for publication.
-
Y. Wakabayashi, M. Kobayashi, S. Akashi-Takamura, K. Konno, K. Takahashi, T. Ishii, T. Mizutani, H. Iba, Y. Oda, S.-i. Saitoh, K. Miyake, A protein associated with Toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4, submitted for publication.
-
A Protein Associated with Toll-Like Receptor 4 (prat4a) Regulates Cell Surface Expression of TLR4
-
-
Wakabayashi, Y.1
Kobayashi, M.2
Akashi-Takamura, S.3
Konno, K.4
Takahashi, K.5
Ishii, T.6
Mizutani, T.7
Iba, H.8
Oda, Y.9
Saitoh, S.-I.10
Miyake, K.11
-
26
-
-
0035881675
-
Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
-
A.T. Gewirtz, T.A. Navas, S. Lyons, P.J. Godowski, and J.L. Madara Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression J. Immunol. 167 2001 1882 1885
-
(2001)
J. Immunol.
, vol.167
, pp. 1882-1885
-
-
Gewirtz, A.T.1
Navas, T.A.2
Lyons, S.3
Godowski, P.J.4
Madara, J.L.5
|