Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 2, 2006, Pages 395-408

  Park, Jewn Giew ^a   Sill, Peter C ^a   Makiyi, Edward F ^a   Garcia Sosa, Alfonso T ^a   Millard, Charles B ^b   Schmidt, James J ^c   Pang, Yuan Ping ^a  

^a MAYO CLINIC   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

Antidotes; Countermeasures; Protease; Structure based drug design; Zinc protein simulations

Indexed keywords

BOTULINUM TOXIN; CATION; ENZYME INHIBITOR; ION; PROTEINASE; ZINC;

ARTICLE; ATOM; CATALYSIS; ENZYME ACTIVE SITE; EVALUATION; HIGH THROUGHPUT SCREENING; MOLECULAR DYNAMICS; MOLECULE; SEROTYPE; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

BOTULINUM TOXIN TYPE A; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENDOPEPTIDASES; MAGNETIC RESONANCE SPECTROSCOPY; PROTEASE INHIBITORS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED;

EID: 28844505096     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.08.018     Document Type: Article

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