(2,2':6',2'-Terpyridine)platinum(II) complexes are irreversible inhibitors of Trypanosoma cruzi trypanothione reductase but not of human glutathione reductase

Journal of Medicinal Chemistry

Volumn 43, Issue 25, 2000, Pages 4812-4821

  Bonse, S ^a   Richards, J M ^b   Ross, S A ^b   Lowe, G ^b   Krauth Siegel, R L ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; ENZYME INHIBITOR; GLUTATHIONE REDUCTASE; PLATINUM COMPLEX; PYRIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL; TRYPANOTHIONE REDUCTASE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; CYTOSTASIS; DRUG EFFICACY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MODIFICATION; HUMAN; INHIBITION KINETICS; LEISHMANIA; NONHUMAN; SPECTROSCOPY; TRYPANOSOMA CRUZI;

2,2'-DIPYRIDYL; ANIMALS; DIALYSIS; ENZYME INHIBITORS; GLUTATHIONE REDUCTASE; HUMANS; KINETICS; LIGANDS; NADH, NADPH OXIDOREDUCTASES; ORGANOPLATINUM COMPOUNDS; OXIDATION-REDUCTION; SPECTROPHOTOMETRY; SULFHYDRYL COMPOUNDS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 0034649656     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000219o     Document Type: Article

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