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Volumn 19, Issue 12, 2005, Pages 2215-2222

Activated natural killer cells from patients with acute myeloid leukemia are cytotoxic against autologous leukemic blasts in NOD/SCID mice

Author keywords

AML; Antileukemia immunity; Immunotherapy; NK activating receptors; NK cells; NOD SCID mice

Indexed keywords

CD3 ANTIGEN; CD56 ANTIGEN; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; INTERLEUKIN 2; NATURAL KILLER CELL RECEPTOR NKG2D;

EID: 28544432065     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2403985     Document Type: Article
Times cited : (54)

References (46)
  • 1
    • 0024792513 scopus 로고
    • Biology of natural killer cells
    • Trinchieri G. Biology of natural killer cells. Adv Immunol 1989; 47: 187-376.
    • (1989) Adv. Immunol. , vol.47 , pp. 187-376
    • Trinchieri, G.1
  • 3
    • 0035059950 scopus 로고    scopus 로고
    • Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis
    • Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari MC et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 2001; 19: 197-223.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 197-223
    • Moretta, A.1    Bottino, C.2    Vitale, M.3    Pende, D.4    Cantoni, C.5    Mingari, M.C.6
  • 4
    • 0033618504 scopus 로고    scopus 로고
    • Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    • Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999; 285: 727-729.
    • (1999) Science , vol.285 , pp. 727-729
    • Bauer, S.1    Groh, V.2    Wu, J.3    Steinle, A.4    Phillips, J.H.5    Lanier, L.L.6
  • 5
    • 0035099068 scopus 로고    scopus 로고
    • ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
    • Cosman D, Mullberg J, Sutherland CL, Chin W, Armitage R, Fanslow W et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 2001; 14: 123-133.
    • (2001) Immunity , vol.14 , pp. 123-133
    • Cosman, D.1    Mullberg, J.2    Sutherland, C.L.3    Chin, W.4    Armitage, R.5    Fanslow, W.6
  • 6
    • 0033007567 scopus 로고    scopus 로고
    • Regulation of immune responses through inhibitory receptors
    • Long EO. Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 1999; 17: 875-904.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 875-904
    • Long, E.O.1
  • 7
    • 9444249908 scopus 로고    scopus 로고
    • Natural killer cell signaling pathways
    • Vivier E, Nunes JA, Vely F. Natural killer cell signaling pathways. Science 2004; 306: 1517-1519.
    • (2004) Science , vol.306 , pp. 1517-1519
    • Vivier, E.1    Nunes, J.A.2    Vely, F.3
  • 8
    • 3042569008 scopus 로고    scopus 로고
    • Learning how to discriminate between friends and enemies, a lesson from natural killer cells
    • Bottino C, Moretta L, Pende D, Vitale M, Moretta A. Learning how to discriminate between friends and enemies, a lesson from natural killer cells. Mol Immunol 2004; 41: 569-575.
    • (2004) Mol. Immunol. , vol.41 , pp. 569-575
    • Bottino, C.1    Moretta, L.2    Pende, D.3    Vitale, M.4    Moretta, A.5
  • 9
    • 0036831613 scopus 로고    scopus 로고
    • New aspects of natural-killer-cell surveillance and therapy of cancer
    • Smyth MJ, Hayakawa Y, Takeda K, Yagita H. New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer 2002; 2: 850-861.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 850-861
    • Smyth, M.J.1    Hayakawa, Y.2    Takeda, K.3    Yagita, H.4
  • 10
    • 2342664929 scopus 로고    scopus 로고
    • Cellular immunotherapy and cancer
    • Waller EK. Cellular immunotherapy and cancer. Semin Oncol 2004; 31: 87-90.
    • (2004) Semin. Oncol. , vol.31 , pp. 87-90
    • Waller, E.K.1
  • 11
    • 0033168770 scopus 로고    scopus 로고
    • Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation
    • Ruggeri L, Capanni M, Casucci M, Volpi I, Tosti A, Perruccio K et al. Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood 1999; 94: 333-339.
    • (1999) Blood , vol.94 , pp. 333-339
    • Ruggeri, L.1    Capanni, M.2    Casucci, M.3    Volpi, I.4    Tosti, A.5    Perruccio, K.6
  • 12
    • 10744230735 scopus 로고    scopus 로고
    • Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors
    • Giebel S, Locatelli F, Lamparelli T, Velardi A, Davies S, Frumento G et al. Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors. Blood 2003; 102: 814-819.
    • (2003) Blood , vol.102 , pp. 814-819
    • Giebel, S.1    Locatelli, F.2    Lamparelli, T.3    Velardi, A.4    Davies, S.5    Frumento, G.6
  • 13
    • 15244346488 scopus 로고    scopus 로고
    • Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias
    • Beelen DW, Ottinger HD, Ferencik S, Elmaagacli AH, Peceny R, Trenschel R et al. Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias. Blood 2005; 105: 2594-2600.
    • (2005) Blood , vol.105 , pp. 2594-2600
    • Beelen, D.W.1    Ottinger, H.D.2    Ferencik, S.3    Elmaagacli, A.H.4    Peceny, R.5    Trenschel, R.6
  • 14
    • 2442616949 scopus 로고    scopus 로고
    • Natural killer cell depletion confounds the antitumor mechanism of endogenous IL-12 overexpression
    • Miller G, Bleier JI, Antonescu C, Pillarisetty VG, Shah AB, Lahrs S et al. Natural killer cell depletion confounds the antitumor mechanism of endogenous IL-12 overexpression. Int J Cancer 2004; 110: 395-402.
    • (2004) Int. J. Cancer , vol.110 , pp. 395-402
    • Miller, G.1    Bleier, J.I.2    Antonescu, C.3    Pillarisetty, V.G.4    Shah, A.B.5    Lahrs, S.6
  • 15
    • 8844228916 scopus 로고    scopus 로고
    • Purified donor NK-lymphocyte infusion to consolidate engraftment after haploidentical stem cell transplantation
    • Passweg JR, Tichelli A, Meyer-Monard S, Heim D, Stern M, Kuhne T et al. Purified donor NK-lymphocyte infusion to consolidate engraftment after haploidentical stem cell transplantation. Leukemia 2004; 18: 1835-1838.
    • (2004) Leukemia , vol.18 , pp. 1835-1838
    • Passweg, J.R.1    Tichelli, A.2    Meyer-Monard, S.3    Heim, D.4    Stern, M.5    Kuhne, T.6
  • 17
    • 20144388509 scopus 로고    scopus 로고
    • Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in cancer patients
    • Miller JS, Soignier Y, Panoskaltsis-Mortari A, McNearney SA, Yun GH, Fautsch SK et al. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in cancer patients. Blood 2005; 105: 3051-3057.
    • (2005) Blood , vol.105 , pp. 3051-3057
    • Miller, J.S.1    Soignier, Y.2    Panoskaltsis-Mortari, A.3    McNearney, S.A.4    Yun, G.H.5    Fautsch, S.K.6
  • 18
    • 0037093066 scopus 로고    scopus 로고
    • Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia
    • Costello RT, Sivori S, Marcenaro E, Lafage-Pochitaloff M, Mozziconacci MJ, Reviron D et al. Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia. Blood 2002; 99: 3661-3667.
    • (2002) Blood , vol.99 , pp. 3661-3667
    • Costello, R.T.1    Sivori, S.2    Marcenaro, E.3    Lafage-Pochitaloff, M.4    Mozziconacci, M.J.5    Reviron, D.6
  • 19
    • 18244386482 scopus 로고    scopus 로고
    • Ligands for natural killer cell activating receptors are expressed upon maturation of normal myelomonocytic cells but are low in acute myeloid leukemias
    • Nowbakht P, Ionescu MC, Rohner A, Kalberer CP, Rossy E, Mori L et al. Ligands for natural killer cell activating receptors are expressed upon maturation of normal myelomonocytic cells but are low in acute myeloid leukemias. Blood 2005; 105: 3615-3622.
    • (2005) Blood , vol.105 , pp. 3615-3622
    • Nowbakht, P.1    Ionescu, M.C.2    Rohner, A.3    Kalberer, C.P.4    Rossy, E.5    Mori, L.6
  • 20
    • 0038644652 scopus 로고    scopus 로고
    • Human NK cell development in NOD/SCID mice receiving grafts of cord blood CD34+ cells
    • Kalberer CP, Siegler U, Wodnar-Filipowicz A. Human NK cell development in NOD/SCID mice receiving grafts of cord blood CD34+ cells. Blood 2003; 102: 127-135.
    • (2003) Blood , vol.102 , pp. 127-135
    • Kalberer, C.P.1    Siegler, U.2    Wodnar-Filipowicz, A.3
  • 21
    • 0033561762 scopus 로고    scopus 로고
    • Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: Implications for the innate immune response
    • Fehniger TA, Shah MH, Turner MJ, VanDeusen JB, Whitman SP, Cooper MA et al. Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: Implications for the innate immune response. J Immunol 1999; 162: 4511-4520.
    • (1999) J. Immunol. , vol.162 , pp. 4511-4520
    • Fehniger, T.A.1    Shah, M.H.2    Turner, M.J.3    VanDeusen, J.B.4    Whitman, S.P.5    Cooper, M.A.6
  • 22
    • 0031747105 scopus 로고    scopus 로고
    • Serial bone marrow sampling for long-term follow up of human hematopoiesis in NOD/SCID mice
    • Verlinden SF, van Es HH, van Bekkum DW. Serial bone marrow sampling for long-term follow up of human hematopoiesis in NOD/SCID mice. Exp Hematol 1998; 26: 627-630.
    • (1998) Exp. Hematol. , vol.26 , pp. 627-630
    • Verlinden, S.F.1    van Es, H.H.2    van Bekkum, D.W.3
  • 23
    • 0037105453 scopus 로고    scopus 로고
    • Natural killer cell receptors: New biology and insights into the graft-versus-leukemia effect
    • Farag SS, Fehniger TA, Ruggeri L, Velardi A, Caligiuri MA. Natural killer cell receptors: New biology and insights into the graft-versus-leukemia effect. Blood 2002; 100: 1935-1947.
    • (2002) Blood , vol.100 , pp. 1935-1947
    • Farag, S.S.1    Fehniger, T.A.2    Ruggeri, L.3    Velardi, A.4    Caligiuri, M.A.5
  • 24
    • 0034933714 scopus 로고    scopus 로고
    • Non-MHC-restricted cytotoxic cells: Their roles in the control and treatment of leukaemias
    • Lowdell MW, Lamb L, Hoyle C, Velardi A, Prentice HG. Non-MHC-restricted cytotoxic cells: Their roles in the control and treatment of leukaemias. Br J Haematol 2001; 114: 11-24.
    • (2001) Br. J. Haematol. , vol.114 , pp. 11-24
    • Lowdell, M.W.1    Lamb, L.2    Hoyle, C.3    Velardi, A.4    Prentice, H.G.5
  • 25
    • 0036175685 scopus 로고    scopus 로고
    • Expansion of cytotoxic effectors with lytic activity against autologous blasts from acute myeloid leukaemia patients in complete haematological remission
    • Torelli GF, Guarini A, Palmieri G, Breccia M, Vitale A, Santoni A et al. Expansion of cytotoxic effectors with lytic activity against autologous blasts from acute myeloid leukaemia patients in complete haematological remission. Br J Haematol 2002; 116: 299-307.
    • (2002) Br. J. Haematol. , vol.116 , pp. 299-307
    • Torelli, G.F.1    Guarini, A.2    Palmieri, G.3    Breccia, M.4    Vitale, A.5    Santoni, A.6
  • 26
    • 0025290664 scopus 로고
    • Diminished A-LAK cytotoxicity and proliferation accompany disease progression in chronic myelogenous leukemia
    • Verfaillie C, Kay N, Miller W, McGlave P. Diminished A-LAK cytotoxicity and proliferation accompany disease progression in chronic myelogenous leukemia. Blood 1990; 76: 401-408.
    • (1990) Blood , vol.76 , pp. 401-408
    • Verfaillie, C.1    Kay, N.2    Miller, W.3    McGlave, P.4
  • 27
    • 0031474337 scopus 로고    scopus 로고
    • The role of autologous natural killer cells in chronic myelogenous leukemia
    • Pierson BA, Miller JS. The role of autologous natural killer cells in chronic myelogenous leukemia. Leuk Lymphoma 1997; 27: 387-399.
    • (1997) Leuk. Lymphoma. , vol.27 , pp. 387-399
    • Pierson, B.A.1    Miller, J.S.2
  • 28
    • 0036283538 scopus 로고    scopus 로고
    • Evidence that continued remission in patients treated for acute leukaemia is dependent upon autologous natural killer cells
    • Lowdell MW, Craston R, Samuel D, Wood ME, O'Neill E, Saha V et al. Evidence that continued remission in patients treated for acute leukaemia is dependent upon autologous natural killer cells. Br J Haematol 2002; 117: 821-827.
    • (2002) Br. J. Haematol. , vol.117 , pp. 821-827
    • Lowdell, M.W.1    Craston, R.2    Samuel, D.3    Wood, M.E.4    O'Neill, E.5    Saha, V.6
  • 29
    • 2342519992 scopus 로고    scopus 로고
    • Reconstitution of dendritic, natural killer-cell subsets after allogeneic stem cell transplantation: Effects of endogenous flt3 ligand
    • Chklovskaia E, Nowbakht P, Nissen C, Gratwohl A, Bargetzi M, Wodnar-Filipowicz A. Reconstitution of dendritic, natural killer-cell subsets after allogeneic stem cell transplantation: Effects of endogenous flt3 ligand. Blood 2004; 103: 3860-3868.
    • (2004) Blood , vol.103 , pp. 3860-3868
    • Chklovskaia, E.1    Nowbakht, P.2    Nissen, C.3    Gratwohl, A.4    Bargetzi, M.5    Wodnar-Filipowicz, A.6
  • 31
    • 11144294699 scopus 로고    scopus 로고
    • Identification of natural killer cell receptor phenotypes associated with leukemia
    • Verheyden S, Bernier M, Demanet C. Identification of natural killer cell receptor phenotypes associated with leukemia. Leukemia 2004; 18: 2002-2007.
    • (2004) Leukemia , vol.18 , pp. 2002-2007
    • Verheyden, S.1    Bernier, M.2    Demanet, C.3
  • 32
    • 0036129764 scopus 로고    scopus 로고
    • Loss or downregulation of HLA class I expression at the allelic level in acute leukemia is infrequent but functionally relevant, and can be restored by interferon
    • Brouwer RE, van der Heiden P, Schreuder GM, Mulder A, Datema G, Anholts JD et al. Loss or downregulation of HLA class I expression at the allelic level in acute leukemia is infrequent but functionally relevant, and can be restored by interferon. Hum Immunol 2002; 63: 200-210.
    • (2002) Hum. Immunol. , vol.63 , pp. 200-210
    • Brouwer, R.E.1    van der Heiden, P.2    Schreuder, G.M.3    Mulder, A.4    Datema, G.5    Anholts, J.D.6
  • 33
    • 1842526926 scopus 로고    scopus 로고
    • Down-regulation of HLA-A, HLA-Bw6, but not HLA-Bw4, allospecificities in leukemic cells: An escape mechanism from CTL, NK attack?
    • Demanet C, Mulder A, Deneys V, Worsham MJ, Maes P, Claas FH et al. Down-regulation of HLA-A, HLA-Bw6, but not HLA-Bw4, allospecificities in leukemic cells: An escape mechanism from CTL, NK attack? Blood 2004; 103: 3122-3130.
    • (2004) Blood , vol.103 , pp. 3122-3130
    • Demanet, C.1    Mulder, A.2    Deneys, V.3    Worsham, M.J.4    Maes, P.5    Claas, F.H.6
  • 34
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D, T-cell activation
    • Groh V, Wu J, Yee C, Spies T. Tumour-derived soluble MIC ligands impair expression of NKG2D, T-cell activation. Nature 2002; 419: 734-738.
    • (2002) Nature , vol.419 , pp. 734-738
    • Groh, V.1    Wu, J.2    Yee, C.3    Spies, T.4
  • 35
    • 0032945045 scopus 로고    scopus 로고
    • NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46, natural cytotoxicity against autologous, allogeneic or xenogeneic target cells
    • Sivori S, Pende D, Bottino C, Marcenaro E, Pessino A, Biassoni R et al. NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46, natural cytotoxicity against autologous, allogeneic or xenogeneic target cells. Eur J Immunol 1999; 29: 1656-1666.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 1656-1666
    • Sivori, S.1    Pende, D.2    Bottino, C.3    Marcenaro, E.4    Pessino, A.5    Biassoni, R.6
  • 36
    • 0034998410 scopus 로고    scopus 로고
    • ULBP1, 2, 3: Novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells
    • Kubin M, Cassiano L, Chalupny J, Chin W, Cosman D, Fanslow W et al. ULBP1, 2, 3: Novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. Eur J Immunol 2001; 31: 1428-1437.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1428-1437
    • Kubin, M.1    Cassiano, L.2    Chalupny, J.3    Chin, W.4    Cosman, D.5    Fanslow, W.6
  • 37
    • 0041737499 scopus 로고    scopus 로고
    • Functional expression, release of ligands for the activating immunoreceptor NKG2D in leukemia
    • Salih HR, Antropius H, Gieseke F, Lutz SZ, Kanz L, Rammensee HG et al. Functional expression, release of ligands for the activating immunoreceptor NKG2D in leukemia. Blood 2003; 102: 1389-1396.
    • (2003) Blood , vol.102 , pp. 1389-1396
    • Salih, H.R.1    Antropius, H.2    Gieseke, F.3    Lutz, S.Z.4    Kanz, L.5    Rammensee, H.G.6
  • 38
    • 0037086131 scopus 로고    scopus 로고
    • Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    • Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002; 295: 2097-2100.
    • (2002) Science , vol.295 , pp. 2097-2100
    • Ruggeri, L.1    Capanni, M.2    Urbani, E.3    Perruccio, K.4    Shlomchik, W.D.5    Tosti, A.6
  • 39
    • 0033198630 scopus 로고    scopus 로고
    • Growth characteristics of acute myelogenous leukemia progenitors that initiate malignant hematopoiesis in nonobese diabetic/severe combined immunodeficient mice
    • Ailles LE, Gerhard B, Kawagoe H, Hogge DE. Growth characteristics of acute myelogenous leukemia progenitors that initiate malignant hematopoiesis in nonobese diabetic/severe combined immunodeficient mice. Blood 1999; 94: 1761-1772.
    • (1999) Blood , vol.94 , pp. 1761-1772
    • Ailles, L.E.1    Gerhard, B.2    Kawagoe, H.3    Hogge, D.E.4
  • 40
    • 0035855872 scopus 로고    scopus 로고
    • Rae1, H60 ligands of the NKG2D receptor stimulate tumour immunity
    • Diefenbach A, Jensen ER, Jamieson AM, Raulet DH. Rae1, H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 2001; 413: 165-171.
    • (2001) Nature , vol.413 , pp. 165-171
    • Diefenbach, A.1    Jensen, E.R.2    Jamieson, A.M.3    Raulet, D.H.4
  • 41
    • 10844263473 scopus 로고    scopus 로고
    • Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells, up-regulated by trans-retinoic acid
    • Poggi A, Venturino C, Catellani S, Clavio M, Miglino M, Gobbi M et al. Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells, up-regulated by trans-retinoic acid. Cancer Res 2004; 64: 9172-9179.
    • (2004) Cancer Res. , vol.64 , pp. 9172-9179
    • Poggi, A.1    Venturino, C.2    Catellani, S.3    Clavio, M.4    Miglino, M.5    Gobbi, M.6
  • 43
    • 0036040029 scopus 로고    scopus 로고
    • Current controversies: Which patients with acute myeloid leukaemia should receive a bone marrow transplantation? - An adult treater's view
    • Burnett AK. Current controversies: Which patients with acute myeloid leukaemia should receive a bone marrow transplantation? - an adult treater's view. Br J Haematol 2002; 118: 357-364.
    • (2002) Br. J. Haematol. , vol.118 , pp. 357-364
    • Burnett, A.K.1
  • 44
    • 7444260211 scopus 로고    scopus 로고
    • IL-2 activated NK cell immunotherapy of three children after haploidentical stem cell transplantation
    • Koehl U, Sorensen J, Esser R, Zimmermann S, Gruttner HP, Tonn T et al. IL-2 activated NK cell immunotherapy of three children after haploidentical stem cell transplantation. Blood Cells Mol Dis 2004; 33: 261-266.
    • (2004) Blood Cells Mol. Dis. , vol.33 , pp. 261-266
    • Koehl, U.1    Sorensen, J.2    Esser, R.3    Zimmermann, S.4    Gruttner, H.P.5    Tonn, T.6
  • 45
    • 0033120418 scopus 로고    scopus 로고
    • A pilot study of interleukin-2 for adult patients with acute myelogenous leukemia in first complete remission
    • Cortes JE, Kantarjian HM, O'Brien S, Giles F, Keating MJ, Freireich EJ et al. A pilot study of interleukin-2 for adult patients with acute myelogenous leukemia in first complete remission. Cancer 1999; 85: 1506-1513.
    • (1999) Cancer , vol.85 , pp. 1506-1513
    • Cortes, J.E.1    Kantarjian, H.M.2    O'Brien, S.3    Giles, F.4    Keating, M.J.5    Freireich, E.J.6


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