Selectivity of SB203580, SB202190 and other commonly used p38 inhibitors: Profiling against a multi-enzyme panel

Letters in Drug Design and Discovery

Volumn 2, Issue 7, 2005, Pages 516-521

  Norris, Jacqueline L ^a   Williams, Kevin P ^a   Janzen, William P ^a   Hodge, C Nicholas ^a   Blackwell, Leonard J ^a   Popa Burke, Ioana G ^a  

^a Amphora Discovery Corporation   (United States)

Author keywords

Inflammatory response; Inhibitor specificity; MAPK; p38; p38 inhibitors

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; 5 (2 AMINO 4 PYRIMIDINYL) 4 (4 FLUOROPHENYL) 1 (4 PIPERIDINYL)IMIDAZOLE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN INHIBITOR; SC 68376; SYNAPTOPHYSIN;

ARTICLE; DRUG SCREENING; DRUG SELECTIVITY; ENZYME ACTIVITY; INFLAMMATION; MEDICAL RESEARCH; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 28444491357     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018005774479159     Document Type: Article

References (35)

1. Roux, P.P.; Blenis, J. Microbio. Mol. Bio. Rev., 2004, 68, 320.
2. Bogoyevitch, M.A.; Boehm, I.; Oakley, A.; Ketterman, A.J.; Barr, R.K. Biochim. Biophy. Acta, 2004, 1697, 89.
3. Herlaar, E.; Brown, Z. Mol. Med. Today, 1999, 5, 439.
4. Kumar, S.; Boehm, J.; Lee, J.C. Nat. Rev. Drug Discov., 2003, 2, 717.
5. Shi, Y.; Gaestel, M. Biol. Chem., 2002, 383, 1519.
6. Kumar S.; McDonnell, P.C.; Gum, RJ.; Hand, A.T; Lee, J.C.; Young, P.R. Biochem. Biophy. Res. Comm., 1997, 235, 533.
7. Han, J.; Lee, J.D.; Bibbs, L.; Ulevitch, R.J. Science, 1994, 265, 808.
8. Hale, K.K.; Trollinger, D.; Rihanek, M.; Manthey, C.L. J. Immunol., 1999, 162,4246.
9. Lee J.C.; Laydon, J.T.; McDonnell, P.C.; Gallagher, T.F.; Kumar, S.; Green, D.; McNulty, D.; Blumenthal, M.J.; Heys, J.R.; Landvatter, S.W.; Strickler, J.E.; McLaughlin, M.M.; Siemens, I.R.; Fisher, S.M.; Livi, G.P.; White, J.R.; Adams, J.L; Young, P.R. Nature, 1994, 372, 739.
10. Stein, B.; Yang, M.X.; Yound, D.B.; Janknecht, R.; Hunter, T.; Murray, B.W.; Barbosa, M.S. J. Biol. Chem., 1997, 272, 19509.
11. Jiang, Y.; Chen, C.; Li, Z.; Guo, W.; Genger, J.; Lin, S.; Han, J. J. Biol. Chem., 1996, 271, 17920.
12. Jiang, Y.; Gram, H.; Zhao, M.; New, L.; Gu, J.; Feng, L.; Di Padova, F.; Ulevitch, R.; Han, J. J. Biol. Chem., 1997, 272, 30122.
13. Wang, X.S.; Diener, K.; Manthey, C.L.; Wang, S,-W.; Rosensweig, B.; Bray, J.; Delaney, J.; Cole, C.N.; Chan-Hui, P.-Y.; Mantlo, N.; Lichenstein, H.S.; Zukowski, M.; Yao, Z. J. Biol. Chem., 1997, 272, 23668.
14. Lee, J.C.; Kumar, S.; Griswold, D.E.; Underwood, D.C.; Votta, B.J.; Adams, J.L. Immunopharmacology, 2000, 47, 185.
15. Adams, J.L.; Boehm, J.C.; Kassis, S.; Gorycki, P.D.; Webb, E.F.; Hall, R.; Sorenson, M.; Lee, J.C.; Ayrton, A.; Griswold, D.E.; Gallagher, T.F. Bioorg. Med. Chem. Lett., 1998, 8, 3111.
16. Cohen, P. Nat. Rev. Drug Discov., 2002, 1, 309.
17. Lee, J.C.; Badger, A.M.; Griswold, D.E.; Dunnington, D.; Truneh, A.; Votta, B.; White, J.R.; Young, P.R.; Bender, P.E. Ann. N.Y. Acad. Sci., 1993, 896, 149.
18. Jackson, J.R.; Bolognese, B.; Hillegass, L.; Kassis, S.; Adams, J.; Griswold, D.E.; Winkler, J.D. J. Pharmacol. Exp. Ther., 1998, 284, 687.
19. Barone, F.C.; Irving, E.A.; Ray, A.M.; Lee, J.C.; Kassis, S.; Kumar, S.; Badger, A.M.; White, R.F.; Mcvey, M.J.; Legos, J.J.; Erhardt, J.A.; Nelson, A.H.; Ohlstein, E.H.; Hunter, A.J.; Ward, K.; Smith, B.R.; Adams, J.L.; Parsons, A.A. J. Pharmacol. Exp. Ther., 2001, 296, 312.
20. Guan, Z.; Baier, L.D.; Morrison, A.R. J. Biol. Chem., 1997, 272, 8083.
21. Kummer, J.L.; Rao, P.K.; Heidenreich, K.A. J. Biol. Chem., 1997, 272, 20490.
22. Assefa, Z.; Vantieghem, A.; Garmyn, M.; Declercq, W.; Vandenabeele, P.; Vandenheede, J.R.; Bouillon, R.; Merlevede, W.; Agostinis, P. J. Biol. Chem., 2000, 275, 21416.
23. Davies, S.P.; Reddy, H.; Caivano, M.; Cohen, P. Biochem. J., 2000, 351, 95.
24. Godl, K.; Wissing, J.; Kurtenbach, A.; Habenberger, P.; Blencke, S.; Gutbrod, H.; Salassidis, K.; Stein-Gerlach, M.; Missio, A.; Cotton, M.; Daub, H. Proc. Natl. Acad. Sci. USA, 2003, 100, 15434.
25. Janzen, W.; Bernasconi, P.; Cheatham, L.; Mansky, P.; Popa-Burke, L; Williams, K.; Worley, J.; Hodge, N. In Chemical Genomics; Darvas, Guttman, and Dorman Editors; Marcel Dekker: NY, NY, 2004, pp.59-100.
26. Wu, G.; Yuan, Y.; Hodge, C.N. J. Biomol. Screen., 2003, 8, 694.
27. Popa-Burke, IG.; Issakova, O.; Arroway, J.D.; Bernasconi, P.; Chen, M.; Coudurier, L.; Galasinski, S.; Jadhav, A.P.; Janzen, W.P.; Lagasca, D.; Liu, D.; Lewis, R.S.; Mohney, R.P.; Sepetov, N.; Sparkman, D.A.; Hodge, C.N. Anal. Chem., 2004, 76, 7278.
28. Cheng, Y.; Prusoff, W. H. Biochem. Pharmacol., 1973, 22, 3099.
29. Manning, G.; Whyte, D.B.; Martinez, R.; Hunter, T.; Sudarsanan, S. Science, 2002, 298, 1912.
30. Gallagher, T.F.; Seibel, G.L.; Kassis, S.; Laydon, J.T.; Blumenthal, M.J.; Lee, J.C.; Lee, D.; Boehm, J.C.; Fier-Thompson, S.M.; Abt, J.W.; Soreson, M.E.; Smietana, J.M.; Hall, R.F.; Garigipati, R.S.; Bender, P.E.; Erhard, K.F.; Krog, A.J.; Hofmann, G.A.; Sheldrake, P.L.; McDonnell, P.C.; Kumar, S.; Young, P.R.; Adams, J.L. Bioorg. Med. Chem., 1997, 5, 49.
31. Whitmarsh, A.J.; Yang, S.-H.; Su. M.S.-S.; Sharrocks, A.D.; Davis, R.J. Mol. Cell. Biol., 1997,17, 2360.
32. Dubois, T.; Howell, S.; Zemlickova, E.; Aitken, A. FEBS Lett., 2002,517, 167.
33. Jope, R.; Johnson, G.V.W. Trends Biochem. Sci., 2004, 29, 95.
34. Izeradjene, K.; Douglas, L.; Delaney, A.B.; Houghton, J.A. Cancer Res., 2004, 64, 8036.
35. Kuma, Y.; Campbell, D.G.; Cuenda, A. Biochem. J., 2004, 379, 133.