Knockdown of glutamate-cysteine by ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons

Journal of Biological Chemistry

Volumn 280, Issue 47, 2005, Pages 38992-39001

  Diaz Hernandez, Juan I ^a,b   Almeida, Angeles ^a,b   Delgado Esteban, Maria ^b   Fernandez, Emilio ^b   Bolaños, Juan P ^b  

^a HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CONCENTRATION (PROCESS); ENZYMES;

GLUTAMYLCYSTEINE; GLUTATHIONE BIOSYNTHESIS; NEURONS; PARKINSON DISEASE;

RNA;

COMPLEMENTARY DNA; GAMMA GLUTAMYLCYSTEINE; GLUTAMATE CYSTEINE LIGASE; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; NITRIC OXIDE; RNA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CATALYSIS; CELL STRAIN HEK293; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DNA SEQUENCE; ENZYME ACTIVITY; EXCISION REPAIR; FETUS; GENE MUTATION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SEQUENCE ANALYSIS; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL SURVIVAL; CELLS, CULTURED; GLUTAMATE-CYSTEINE LIGASE; GLUTAMIC ACID; HUMANS; NERVE DEGENERATION; NEURONS; NITRIC OXIDE; PROTEIN SUBUNITS; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

ANIMALIA;

EID: 28244459619     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M507065200     Document Type: Article

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