-
1
-
-
0034075822
-
Therapeutic drug monitoring of sirolimus: Correlations with efficacy and toxicity
-
Kahan BD, Napoli KL, Kelly PA et al. Therapeutic drug monitoring of sirolimus: correlations with efficacy and toxicity. Clin Transplant 2000; 14: 97-109.
-
(2000)
Clin Transplant
, vol.14
, pp. 97-109
-
-
Kahan, B.D.1
Napoli, K.L.2
Kelly, P.A.3
-
2
-
-
0031863355
-
Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine
-
Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. J Pharmacol Exp Ther 1998; 285: 1104-1112.
-
(1998)
J Pharmacol Exp Ther
, vol.285
, pp. 1104-1112
-
-
Lampen, A.1
Zhang, Y.2
Hackbarth, I.3
Benet, L.Z.4
Sewing, K.F.5
Christians, U.6
-
3
-
-
0033569516
-
Pharmacogenomics: Translating functional genomics into rational therapeutics
-
Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999; 286: 487-491.
-
(1999)
Science
, vol.286
, pp. 487-491
-
-
Evans, W.E.1
Relling, M.V.2
-
4
-
-
0026496950
-
The role of individual human cytochromes P450 in drug metabolism and clinical response
-
Cholerton S, Daly AK, Idle JR. The role of individual human cytochromes P450 in drug metabolism and clinical response. Trends Pharmacol Sci 1992; 13: 434-439.
-
(1992)
Trends Pharmacol Sci
, vol.13
, pp. 434-439
-
-
Cholerton, S.1
Daly, A.K.2
Idle, J.R.3
-
5
-
-
0029126498
-
Cyclosporine and liver transplantation: Will the midazolam test make blood level monitoring obsolete?
-
Watkins PB. Cyclosporine and liver transplantation: will the midazolam test make blood level monitoring obsolete? Hepatology 1995; 22: 994-996.
-
(1995)
Hepatology
, vol.22
, pp. 994-996
-
-
Watkins, P.B.1
-
7
-
-
0035071598
-
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
-
Kuehl P, Zhang J, Lin Y et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 2001; 27: 383-391.
-
(2001)
Nat Genet
, vol.27
, pp. 383-391
-
-
Kuehl, P.1
Zhang, J.2
Lin, Y.3
-
8
-
-
0031786057
-
In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: Comparison with rapamycin
-
Crowe A, Lemaire M. In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: comparison with rapamycin. Pharm Res 1998; 15: 1666-1672.
-
(1998)
Pharm Res
, vol.15
, pp. 1666-1672
-
-
Crowe, A.1
Lemaire, M.2
-
9
-
-
0023447098
-
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
-
Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci U S A 1987; 84: 7735-7738.
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 7735-7738
-
-
Thiebaut, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
10
-
-
0032900953
-
Biochemical, cellular, and pharmacological aspects of the multidrug transporter
-
Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 1999; 39: 361-398.
-
(1999)
Annu Rev Pharmacol Toxicol
, vol.39
, pp. 361-398
-
-
Ambudkar, S.V.1
Dey, S.2
Hrycyna, C.A.3
Ramachandra, M.4
Pastan, I.5
Gottesman, M.M.6
-
11
-
-
1642523162
-
Polymorphisms in human MDR1 (P-glycoprotein); recent advances and clinical relevance
-
Marzolini C, Paus E, Buclin T, Kim RB. Polymorphisms in human MDR1 (P-glycoprotein); recent advances and clinical relevance. Clin Pharmacol Ther 2004; 75: 13-33.
-
(2004)
Clin Pharmacol Ther
, vol.75
, pp. 13-33
-
-
Marzolini, C.1
Paus, E.2
Buclin, T.3
Kim, R.B.4
-
12
-
-
0034744113
-
No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients
-
von Ahsen N, Richter M, Grupp C, Ringe B, Oellerich M, Armstrong VW. No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients. Clin Chem 2001; 47: 1048-1052.
-
(2001)
Clin Chem
, vol.47
, pp. 1048-1052
-
-
Von Ahsen, N.1
Richter, M.2
Grupp, C.3
Ringe, B.4
Oellerich, M.5
Armstrong, V.W.6
-
13
-
-
0041831261
-
Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus
-
Hesselink DA, van Schaik RH, van der Heiden IP et al. Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus. Clin Pharmacol Ther 2003; 74: 245-254.
-
(2003)
Clin Pharmacol Ther
, vol.74
, pp. 245-254
-
-
Hesselink, D.A.1
Van Schaik, R.H.2
Van Der Heiden, I.P.3
-
14
-
-
0242332169
-
Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients
-
Thervet E, Anglicheau D, King B et al. Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients. Transplantation 2003; 76: 1233-1235.
-
(2003)
Transplantation
, vol.76
, pp. 1233-1235
-
-
Thervet, E.1
Anglicheau, D.2
King, B.3
-
15
-
-
12144286933
-
The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients
-
Haufroid V, Mourad M, Van Kerckhove V et al. The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients. Pharmacogenetics 2004; 14: 147-154.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 147-154
-
-
Haufroid, V.1
Mourad, M.2
Van Kerckhove, V.3
-
16
-
-
0037693831
-
Tacrolimus dosing in pediatric heart transplant patients is related to CYP3A5 and MDR1 gene polymorphisms
-
Zheng H, Webber S, Zeevi A et al. Tacrolimus dosing in pediatric heart transplant patients is related to CYP3A5 and MDR1 gene polymorphisms. Am J Transplant 2003; 3: 477-483.
-
(2003)
Am J Transplant
, vol.3
, pp. 477-483
-
-
Zheng, H.1
Webber, S.2
Zeevi, A.3
-
17
-
-
11144358432
-
CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation
-
Anglicheau D, Thervet E, Etienne I et al. CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation. Clin Pharmacol Ther 2004; 75: 422-433.
-
(2004)
Clin Pharmacol Ther
, vol.75
, pp. 422-433
-
-
Anglicheau, D.1
Thervet, E.2
Etienne, I.3
-
18
-
-
0026662551
-
Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat
-
Sattler M, Guengerich FP, Yun CH, Christians U, Sewing KF. Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metab Dispos 1992; 20: 753-761.
-
(1992)
Drug Metab Dispos
, vol.20
, pp. 753-761
-
-
Sattler, M.1
Guengerich, F.P.2
Yun, C.H.3
Christians, U.4
Sewing, K.F.5
-
19
-
-
0016916438
-
Prediction of creatinine clearance from serum creatinine
-
Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31-41.
-
(1976)
Nephron
, vol.16
, pp. 31-41
-
-
Cockcroft, D.W.1
Gault, M.H.2
-
20
-
-
0025732253
-
Testing for association between disease and linked marker loci: A log-linear-model analysis
-
Tiret L, Amouyel P, Rakotovao R, Cambien F, Ducimetiere P. Testing for association between disease and linked marker loci: a log-linear-model analysis. Am J Hum Genet 1991; 48: 926-934.
-
(1991)
Am J Hum Genet
, vol.48
, pp. 926-934
-
-
Tiret, L.1
Amouyel, P.2
Rakotovao, R.3
Cambien, F.4
Ducimetiere, P.5
-
21
-
-
0038304548
-
Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients
-
Anglicheau D, Verstuyft C, Laurent-Puig P et al. Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients. J Am Soc Nephrol 2003; 14: 1889-1896.
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 1889-1896
-
-
Anglicheau, D.1
Verstuyft, C.2
Laurent-Puig, P.3
-
22
-
-
3042772026
-
Identification of functionally variant MDR1 alleles among European Americans and African Americans
-
Kim RB, Leake BF, Choo EF et al. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther 2001; 70: 189-199.
-
(2001)
Clin Pharmacol Ther
, vol.70
, pp. 189-199
-
-
Kim, R.B.1
Leake, B.F.2
Choo, E.F.3
-
23
-
-
13144256680
-
The effects of relative timing of sirolimus and cyclosporine microemulsion formulation coadministration on the pharmacokinetics of each agent
-
Kaplan B, Meier-Kriesche HU, Napoli KL, Kahan BD. The effects of relative timing of sirolimus and cyclosporine microemulsion formulation coadministration on the pharmacokinetics of each agent. Clin Pharmacol Ther 1998; 63: 48-53.
-
(1998)
Clin Pharmacol Ther
, vol.63
, pp. 48-53
-
-
Kaplan, B.1
Meier-Kriesche, H.U.2
Napoli, K.L.3
Kahan, B.D.4
-
24
-
-
19244365696
-
Therapeutic drug monitoring of sirolimus: Effect of concomitant immunosuppressive therapy and optimization of drug dosing
-
Cattaneo D, Merlini S, Pellegrino M et al. Therapeutic drug monitoring of sirolimus: effect of concomitant immunosuppressive therapy and optimization of drug dosing. Am J Transplant 2004; 4: 1345-1351.
-
(2004)
Am J Transplant
, vol.4
, pp. 1345-1351
-
-
Cattaneo, D.1
Merlini, S.2
Pellegrino, M.3
-
25
-
-
0028886999
-
Rapamycin: Distribution, pharmacokinetics, and therapeutic range investigations
-
Yatscoff RW, Wang P, Chan K, Hicks D, Zimmerman J. Rapamycin: distribution, pharmacokinetics, and therapeutic range investigations. Ther Drug Monit 1995; 17: 666-671.
-
(1995)
Ther Drug Monit
, vol.17
, pp. 666-671
-
-
Yatscoff, R.W.1
Wang, P.2
Chan, K.3
Hicks, D.4
Zimmerman, J.5
-
26
-
-
12644272784
-
Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine
-
Lown KS, Mayo RR, Leichtman AB et al. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther 1997; 62: 248-260.
-
(1997)
Clin Pharmacol Ther
, vol.62
, pp. 248-260
-
-
Lown, K.S.1
Mayo, R.R.2
Leichtman, A.B.3
-
27
-
-
0035042276
-
Pharmacokinetic interactions augment toxicities of sirolimus/cyclosporine combinations
-
Podder H, Stepkowski SM, Napoli KL et al. Pharmacokinetic interactions augment toxicities of sirolimus/cyclosporine combinations. J Am Soc Nephrol 2001; 12: 1059-1071.
-
(2001)
J Am Soc Nephrol
, vol.12
, pp. 1059-1071
-
-
Podder, H.1
Stepkowski, S.M.2
Napoli, K.L.3
-
29
-
-
0034904077
-
Combination treatment with sirolimus and ciclosporin in clinical renal transplantation: A comprehensive review
-
Yoo SJ, Kahan BD. Combination treatment with sirolimus and ciclosporin in clinical renal transplantation: a comprehensive review. Drugs Today (Barc) 2001; 37: 385-400.
-
(2001)
Drugs Today (Barc)
, vol.37
, pp. 385-400
-
-
Yoo, S.J.1
Kahan, B.D.2
-
30
-
-
0034726386
-
Long-term safety of hepatic hydroxymethyl glutaryl coenzyme A reductase inhibitors: The role of metabolism-monograph for physicians
-
Bottorff M, Hansten P. Long-term safety of hepatic hydroxymethyl glutaryl coenzyme A reductase inhibitors: the role of metabolism-monograph for physicians. Arch Intern Med 2000; 160: 2273-2280.
-
(2000)
Arch Intern Med
, vol.160
, pp. 2273-2280
-
-
Bottorff, M.1
Hansten, P.2
-
31
-
-
0034456656
-
Multidrug resistance transporters and modulation
-
Tan B, Piwnica-Worms D, Ratner L. Multidrug resistance transporters and modulation. Curr Opin Oncol 2000; 12: 450-458.
-
(2000)
Curr Opin Oncol
, vol.12
, pp. 450-458
-
-
Tan, B.1
Piwnica-Worms, D.2
Ratner, L.3
-
32
-
-
0024412071
-
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver: cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCNS for the metabolism of steroid hormones and cyclosporine
-
Aoyama T, Yamano S, Waxman DJ et al. Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver: cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCNS for the metabolism of steroid hormones and cyclosporine. J Biol Chem 1989; 264: 10388-10395.
-
(1989)
J Biol Chem
, vol.264
, pp. 10388-10395
-
-
Aoyama, T.1
Yamano, S.2
Waxman, D.J.3
-
33
-
-
0025161416
-
Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)
-
Wrighton SA, Brian WR, Sari MA et al. Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3). Mol Pharmacol 1990; 38: 207-213.
-
(1990)
Mol Pharmacol
, vol.38
, pp. 207-213
-
-
Wrighton, S.A.1
Brian, W.R.2
Sari, M.A.3
-
34
-
-
0033626281
-
Frequency of cytochrome P450 3A4 variant genotype in transplant population and lack of association with cyclosporin clearance
-
Rivory LP, Qin H, Clarke SJ et al. Frequency of cytochrome P450 3A4 variant genotype in transplant population and lack of association with cyclosporin clearance. Eur J Clin Pharmacol 2000; 56: 395-398.
-
(2000)
Eur J Clin Pharmacol
, vol.56
, pp. 395-398
-
-
Rivory, L.P.1
Qin, H.2
Clarke, S.J.3
-
35
-
-
0032547341
-
Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
-
Rebbeck TR, Jaffe JM, Walker AH, Wein AJ, Malkowicz SB. Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4. J Natl Cancer Inst 1998; 90: 1225-1229.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 1225-1229
-
-
Rebbeck, T.R.1
Jaffe, J.M.2
Walker, A.H.3
Wein, A.J.4
Malkowicz, S.B.5
-
36
-
-
0032756477
-
Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients
-
Paris PL, Kupelian PA, Hall JM et al. Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients. Cancer Epidemiol Biomarkers Prev 1999; 8: 901-905.
-
(1999)
Cancer Epidemiol Biomarkers Prev
, vol.8
, pp. 901-905
-
-
Paris, P.L.1
Kupelian, P.A.2
Hall, J.M.3
-
37
-
-
0345643389
-
Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5′-upstream regulatory region
-
Westlind A, Lofberg L, Tindberg N, Andersson TB, Ingelman-Sundberg M. Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5′-upstream regulatory region. Biochem Biophys Res Commun 1999; 259: 201-205.
-
(1999)
Biochem Biophys Res Commun
, vol.259
, pp. 201-205
-
-
Westlind, A.1
Lofberg, L.2
Tindberg, N.3
Andersson, T.B.4
Ingelman-Sundberg, M.5
-
38
-
-
0032825907
-
Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4
-
Ball SE, Scatina J, Kao J et al. Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4. Clin Pharmacol Ther 1999; 66: 288-294.
-
(1999)
Clin Pharmacol Ther
, vol.66
, pp. 288-294
-
-
Ball, S.E.1
Scatina, J.2
Kao, J.3
-
39
-
-
0000576297
-
Response: Re: Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
-
Amirimani B, Walker AH, Weber BL, Rebbeck TR. Response: Re: modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4. J Natl Cancer Inst 1999; 91: 1588-1590.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1588-1590
-
-
Amirimani, B.1
Walker, A.H.2
Weber, B.L.3
Rebbeck, T.R.4
-
40
-
-
0037115210
-
Tacrolimus pharmacogenetics: Polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement
-
Macphee IA, Fredericks S, Tai T et al. Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement. Transplantation 2002; 74: 1486-1489.
-
(2002)
Transplantation
, vol.74
, pp. 1486-1489
-
-
Macphee, I.A.1
Fredericks, S.2
Tai, T.3
-
41
-
-
0037330517
-
Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients
-
Chowbay B, Cumaraswamy S, Cheung YB, Zhou Q, Lee EJ. Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients. Pharmacogenetics 2003; 13: 89-95.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 89-95
-
-
Chowbay, B.1
Cumaraswamy, S.2
Cheung, Y.B.3
Zhou, Q.4
Lee, E.J.5
-
42
-
-
0037906108
-
The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients
-
Yates CR, Zhang W, Song P et al. The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients. J Clin Pharmacol 2003; 43: 555-564.
-
(2003)
J Clin Pharmacol
, vol.43
, pp. 555-564
-
-
Yates, C.R.1
Zhang, W.2
Song, P.3
|