-
1
-
-
0036849077
-
The biochemistry and medical significance of the flavonoids
-
B.H. Havsteen The biochemistry and medical significance of the flavonoids Pharmacol. Ther. 96 2002 67 202
-
(2002)
Pharmacol. Ther.
, vol.96
, pp. 67-202
-
-
Havsteen, B.H.1
-
2
-
-
3042553559
-
New approaches to the role of diet in the prevention of cancers of the alimentary tract
-
I.T. Johnson New approaches to the role of diet in the prevention of cancers of the alimentary tract Mutat. Res. 551 2004 9 28
-
(2004)
Mutat. Res.
, vol.551
, pp. 9-28
-
-
Johnson, I.T.1
-
3
-
-
0033637140
-
The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
-
E.J. Middleton, C. Kandaswami, and T.C. Theoharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Pharmacol. Rev. 52 2000 673 751
-
(2000)
Pharmacol. Rev.
, vol.52
, pp. 673-751
-
-
Middleton, E.J.1
Kandaswami, C.2
Theoharides, T.C.3
-
4
-
-
0027516446
-
Cancer-protective factors in fruits and vegetables: Biochemical and biological background
-
L.O. Dragsted, M. Strube, and J.C. Larsen Cancer-protective factors in fruits and vegetables: biochemical and biological background Pharmacol. Toxicol. 72 1993 116 135
-
(1993)
Pharmacol. Toxicol.
, vol.72
, pp. 116-135
-
-
Dragsted, L.O.1
Strube, M.2
Larsen, J.C.3
-
6
-
-
0029888128
-
Structure-antioxidant activity relationships of flavonoids and phenolic acids
-
C. Rice-Evans, N.J. Miller, and G. Paganga Structure-antioxidant activity relationships of flavonoids and phenolic acids Free Radic. Biol. Med. 20 1996 933 956
-
(1996)
Free Radic. Biol. Med.
, vol.20
, pp. 933-956
-
-
Rice-Evans, C.1
Miller, N.J.2
Paganga, G.3
-
7
-
-
0035478933
-
The influence of pH on antioxidant properties and the mechanism of antioxidant action of hydroxyflavones
-
K. Lemanska, H. Szymusiak, B. Tyrakowsa, R. Zielinski, A.E.M.F. Soffers, and I.M.C.G. Rietjens The influence of pH on antioxidant properties and the mechanism of antioxidant action of hydroxyflavones Free Radic. Biol. Med. 30 2001 433 446
-
(2001)
Free Radic. Biol. Med.
, vol.30
, pp. 433-446
-
-
Lemanska, K.1
Szymusiak, H.2
Tyrakowsa, B.3
Zielinski, R.4
Soffers, A.E.M.F.5
Rietjens, I.M.C.G.6
-
8
-
-
0037438947
-
Dietary flavonoid iron complexes as cytoprotective radical scavengers
-
M.Y. Moridani, J. Pourahmad, H. Bui, A. Siraki, and P.J. O'Brien Dietary flavonoid iron complexes as cytoprotective radical scavengers Free Radic. Biol. Med. 34 2003 243 253
-
(2003)
Free Radic. Biol. Med.
, vol.34
, pp. 243-253
-
-
Moridani, M.Y.1
Pourahmad, J.2
Bui, H.3
Siraki, A.4
O'Brien, P.J.5
-
9
-
-
0030029472
-
Antioxidant properties of hydroxy-flavones
-
N. Cotelle, J.L. Bernier, J.-P. Catteau, J. Pommery, J.-C. Wallet, and E.M. Gaydou Antioxidant properties of hydroxy-flavones Free Radic. Biol. Med. 20 1996 35 43
-
(1996)
Free Radic. Biol. Med.
, vol.20
, pp. 35-43
-
-
Cotelle, N.1
Bernier, J.L.2
Catteau, J.-P.3
Pommery, J.4
Wallet, J.-C.5
Gaydou, E.M.6
-
10
-
-
0036827942
-
Structure-antioxidant activity relationships of flavonoids: A re-examination
-
M.M. Silva, M.R. Santos, G. Caroco, R. Rocha, G. Justino, and L. Mira Structure-antioxidant activity relationships of flavonoids: a re-examination Free Radic. Res. 36 2002 1219 1277
-
(2002)
Free Radic. Res.
, vol.36
, pp. 1219-1277
-
-
Silva, M.M.1
Santos, M.R.2
Caroco, G.3
Rocha, R.4
Justino, G.5
Mira, L.6
-
11
-
-
0032953597
-
Quantitative structure-activity relationship analysis of phenolic antioxidants
-
E.J. Lien, S. Ren, H.-H. Bui, and R. Wang Quantitative structure-activity relationship analysis of phenolic antioxidants Free Radic. Biol. Med. 26 1999 285 294
-
(1999)
Free Radic. Biol. Med.
, vol.26
, pp. 285-294
-
-
Lien, E.J.1
Ren, S.2
Bui, H.-H.3
Wang, R.4
-
12
-
-
0032531795
-
Influence of iron chelation on the antioxidant activity of flavonoids
-
S.A.B.E. Van Acker, G.P. van Baten, D.J. van den Berg, A. Bast, and W.J.F. van der Vijgh Influence of iron chelation on the antioxidant activity of flavonoids Biochem. Pharmacol. 56 1998 935 943
-
(1998)
Biochem. Pharmacol.
, vol.56
, pp. 935-943
-
-
Van Acker, S.A.B.E.1
Van Baten, G.P.2
Van Den Berg, D.J.3
Bast, A.4
Van Der Vijgh, W.J.F.5
-
13
-
-
0036827673
-
Interactions of flavonoids with iron and copper ions: A mechanism for their antioxidant activity
-
L. Mira, M.T. Fernandez, M. Santos, R. Rocha, M.H. Florencio, and K.R. Jennigs Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity Free Radic. Res. 36 2002 1199 1208
-
(2002)
Free Radic. Res.
, vol.36
, pp. 1199-1208
-
-
Mira, L.1
Fernandez, M.T.2
Santos, M.3
Rocha, R.4
Florencio, M.H.5
Jennigs, K.R.6
-
14
-
-
0029921813
-
Structural aspects of antioxidant activity of flavonoids
-
S.A.B.E. van Acker, D.J. van den Berg, M.N.J.L. Tromp, D.H. Griffon, W.B. van der Bennekom, W.J.F. van der Vijgh, and A. Bast Structural aspects of antioxidant activity of flavonoids Free Radic. Biol. Med. 20 1996 331 342
-
(1996)
Free Radic. Biol. Med.
, vol.20
, pp. 331-342
-
-
Van Acker, S.A.B.E.1
Van Den Berg, D.J.2
Tromp, M.N.J.L.3
Griffon, D.H.4
Van Der Bennekom, W.B.5
Van Der Vijgh, W.J.F.6
Bast, A.7
-
15
-
-
0030781313
-
Protection against oxidative damage of erythrocyte membrane by the flavonoid quercetin and its relation to iron chelating activity
-
M. Ferrali, C. Signorini, B. Caciotti, L. Sugherini, L. Ciccoli, D. Giachetti, and M. Comporti Protection against oxidative damage of erythrocyte membrane by the flavonoid quercetin and its relation to iron chelating activity FEBS Lett. 416 1997 123 129
-
(1997)
FEBS Lett.
, vol.416
, pp. 123-129
-
-
Ferrali, M.1
Signorini, C.2
Caciotti, B.3
Sugherini, L.4
Ciccoli, L.5
Giachetti, D.6
Comporti, M.7
-
16
-
-
4444243992
-
Iron chelators increase the resistance of ataxia telangiectasia cells to oxidative stress
-
R.E. Shackelford, R.P. Manuszak, C.D. Johnson, D.J. Hellrung, C.J. Link, and S. Wang Iron chelators increase the resistance of ataxia telangiectasia cells to oxidative stress DNA Rep. 3 2004 1263 1272
-
(2004)
DNA Rep.
, vol.3
, pp. 1263-1272
-
-
Shackelford, R.E.1
Manuszak, R.P.2
Johnson, C.D.3
Hellrung, D.J.4
Link, C.J.5
Wang, S.6
-
17
-
-
0026095778
-
Inhibition of mammalian 5-lipoxygenase and cyclooxygenase by flavonoids and phenolic dietary additives: Relationship to antioxidant activity and to iron-reducing ability
-
M.J. Laughton, P.J. Evans, M.A. Moroney, J.R.C. Hoult, and B. Halliwell Inhibition of mammalian 5-lipoxygenase and cyclooxygenase by flavonoids and phenolic dietary additives: relationship to antioxidant activity and to iron-reducing ability Biochem. Pharmacol. 42 1991 1673 1681
-
(1991)
Biochem. Pharmacol.
, vol.42
, pp. 1673-1681
-
-
Laughton, M.J.1
Evans, P.J.2
Moroney, M.A.3
Hoult, J.R.C.4
Halliwell, B.5
-
18
-
-
0028842375
-
Heterogeneous effects of natural flavonoids on monooxygenase activities in human and rat liver microsomes
-
M.H. Sies, J. Leclerc, M.C. Canivenc-Lavier, P. Rat, and M. Suschelet Heterogeneous effects of natural flavonoids on monooxygenase activities in human and rat liver microsomes Toxicol. Appl. Pharmacol. 130 1995 73 78
-
(1995)
Toxicol. Appl. Pharmacol.
, vol.130
, pp. 73-78
-
-
Sies, M.H.1
Leclerc, J.2
Canivenc-Lavier, M.C.3
Rat, P.4
Suschelet, M.5
-
19
-
-
0036753143
-
MAPK signaling in neurodegeneration: Influences of flavonoids and of nitric oxide
-
H. Schroeter, C. Boyd, J.P.E. Spencer, R.J. Williams, E. Cadenas, and C. Rice-Evans MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide Neurobiol. Aging 23 2002 861 880
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 861-880
-
-
Schroeter, H.1
Boyd, C.2
Spencer, J.P.E.3
Williams, R.J.4
Cadenas, E.5
Rice-Evans, C.6
-
20
-
-
0034668148
-
Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents
-
R. Agarwal Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents Biochem. Pharmacol. 60 2000 1051 1059
-
(2000)
Biochem. Pharmacol.
, vol.60
, pp. 1051-1059
-
-
Agarwal, R.1
-
21
-
-
0030741461
-
Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis
-
T. Fotsis, M.S. Pepper, E. Aktas, S. Breit, S. Raksu, H. Adlercreutz, K. Wahala, R. Montesano, and L. Schweigerer Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis Cancer Res. 57 1997 2916 2921
-
(1997)
Cancer Res.
, vol.57
, pp. 2916-2921
-
-
Fotsis, T.1
Pepper, M.S.2
Aktas, E.3
Breit, S.4
Raksu, S.5
Adlercreutz, H.6
Wahala, K.7
Montesano, R.8
Schweigerer, L.9
-
22
-
-
7444272077
-
Luteolin inhibits vascular endothelial growth factor-induced angiogenesis: Inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity
-
E. Bagli, M. Stefaniotou, L. Morbidelli, M. Ziche, K. Psillas, C. Murphy, and T. Fotsis Luteolin inhibits vascular endothelial growth factor-induced angiogenesis: inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity Cancer Res. 64 2004 7936 7946
-
(2004)
Cancer Res.
, vol.64
, pp. 7936-7946
-
-
Bagli, E.1
Stefaniotou, M.2
Morbidelli, L.3
Ziche, M.4
Psillas, K.5
Murphy, C.6
Fotsis, T.7
-
23
-
-
0032585932
-
IκB kinases α and β show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin
-
G.W. Peet, and J. Li IκB kinases α and β show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin J. Biol. Chem. 274 1999 32655 32661
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 32655-32661
-
-
Peet, G.W.1
Li, J.2
-
24
-
-
0141637488
-
Epicatechin and its methylated metabolite attenuate UVA-induced oxidative damage to human skin fibroblasts
-
S. Basu-Modak, M.J. Gordon, L.H. Dobson, J.P.E. Spencer, C. Rice-Evans, and R.M. Tyrrell Epicatechin and its methylated metabolite attenuate UVA-induced oxidative damage to human skin fibroblasts Free Radic. Biol. Med. 35 2003 910 921
-
(2003)
Free Radic. Biol. Med.
, vol.35
, pp. 910-921
-
-
Basu-Modak, S.1
Gordon, M.J.2
Dobson, L.H.3
Spencer, J.P.E.4
Rice-Evans, C.5
Tyrrell, R.M.6
-
25
-
-
0037024347
-
Flavonoids differentially regulate IFNγ-induced ICAM-1 expression in human keratinocytes: Molecular mechanisms of action
-
T. Bito, S. Roy, C.K. Sen, T. Shirakawa, A. Gotoh, M. Ueda, M. Ichihashi, and L. Packer Flavonoids differentially regulate IFNγ-induced ICAM-1 expression in human keratinocytes: molecular mechanisms of action FEBS Lett. 520 2002 145 152
-
(2002)
FEBS Lett.
, vol.520
, pp. 145-152
-
-
Bito, T.1
Roy, S.2
Sen, C.K.3
Shirakawa, T.4
Gotoh, A.5
Ueda, M.6
Ichihashi, M.7
Packer, L.8
-
27
-
-
0041816456
-
Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlies their action on neuronal viability
-
J.P.E. Spencer, C. Rice-Evans, and R.J. Williams Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlies their action on neuronal viability J. Biol. Chem. 278 2003 34,783 34,793
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34
-
-
Spencer, J.P.E.1
Rice-Evans, C.2
Williams, R.J.3
-
28
-
-
0035882247
-
Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage
-
A. Barbouti, P.-T. Doulias, B.-Z. Zhu, B. Frei, and D. Galaris Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage Free Radic. Biol. Med. 31 2001 490 498
-
(2001)
Free Radic. Biol. Med.
, vol.31
, pp. 490-498
-
-
Barbouti, A.1
Doulias, P.-T.2
Zhu, B.-Z.3
Frei, B.4
Galaris, D.5
-
30
-
-
0142227699
-
Endosomal and lysosomal effects of desferrioxamine: Protection of HeLa cells from hydrogen peroxide-induced DNA damage and induction of cell cycle arrest
-
P.-T. Doulias, S. Christoforidis, U. Brunk, and D. Galaris Endosomal and lysosomal effects of desferrioxamine: protection of HeLa cells from hydrogen peroxide-induced DNA damage and induction of cell cycle arrest Free Radic. Biol. Med. 35 2003 719 728
-
(2003)
Free Radic. Biol. Med.
, vol.35
, pp. 719-728
-
-
Doulias, P.-T.1
Christoforidis, S.2
Brunk, U.3
Galaris, D.4
-
31
-
-
18844425714
-
The role of compartmentalized redox-active iron on hydrogen peroxide-induced DNA damage and apoptosis
-
M. Tenopoulou, P.-T. Doulias, A. Barbouti, U. Brunk, and D. Galaris The role of compartmentalized redox-active iron on hydrogen peroxide-induced DNA damage and apoptosis Biochem. J. 387 2005 703 710
-
(2005)
Biochem. J.
, vol.387
, pp. 703-710
-
-
Tenopoulou, M.1
Doulias, P.-T.2
Barbouti, A.3
Brunk, U.4
Galaris, D.5
-
32
-
-
1642463971
-
Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage
-
T. Kurz, A. Leake, T. von Zglinicki, and U. Brunk Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage Biochem. J. 378 2004 1039 1045
-
(2004)
Biochem. J.
, vol.378
, pp. 1039-1045
-
-
Kurz, T.1
Leake, A.2
Von Zglinicki, T.3
Brunk, U.4
-
33
-
-
0032533549
-
Iron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts
-
D.C. Radisky, and J. Kaplan Iron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts Biochem. J. 336 1998 201 205
-
(1998)
Biochem. J.
, vol.336
, pp. 201-205
-
-
Radisky, D.C.1
Kaplan, J.2
-
34
-
-
0037448105
-
Intralysosomal iron: A major determinant of oxidant-induced cell death
-
Z.Q. Yu, H.L. Persson, J.W. Eaton, and U.T. Brunk Intralysosomal iron: a major determinant of oxidant-induced cell death Free Radic. Biol. Med. 34 2003 1243 1252
-
(2003)
Free Radic. Biol. Med.
, vol.34
, pp. 1243-1252
-
-
Yu, Z.Q.1
Persson, H.L.2
Eaton, J.W.3
Brunk, U.T.4
-
35
-
-
0037448064
-
Prevention of oxidant-induced lysosomal cell death by lysomotropic iron-chelators
-
H.L. Persson, Z.Q. Yu, J.W. Eaton, and U.T. Brunk Prevention of oxidant-induced lysosomal cell death by lysomotropic iron-chelators Free Radic. Biol. Med. 34 2003 1295 1305
-
(2003)
Free Radic. Biol. Med.
, vol.34
, pp. 1295-1305
-
-
Persson, H.L.1
Yu, Z.Q.2
Eaton, J.W.3
Brunk, U.T.4
-
36
-
-
0023919963
-
A simple technique for quantitation of low levels of DNA damage in individual cells
-
N.P. Singh, T. McCoy, R.R. Tice, and E.L. Schneider A simple technique for quantitation of low levels of DNA damage in individual cells Exp. Cell Res. 184 1988 461 470
-
(1988)
Exp. Cell Res.
, vol.184
, pp. 461-470
-
-
Singh, N.P.1
McCoy, T.2
Tice, R.R.3
Schneider, E.L.4
-
37
-
-
0030995733
-
The comet assay; What can it really tell us?
-
A.R. Collins, V.L. Dobson, M. Dusinska, G. Kennedy, and R. Stetina The comet assay; what can it really tell us? Mutat. Res. 375 1997 183 193
-
(1997)
Mutat. Res.
, vol.375
, pp. 183-193
-
-
Collins, A.R.1
Dobson, V.L.2
Dusinska, M.3
Kennedy, G.4
Stetina, R.5
-
39
-
-
21844470451
-
DNA protecting and genotoxic effects of olive oil related components in cells exposed to hydrogen peroxide
-
L. Nousis, P.-T. Doulias, N. Aligiannis, D. Bazios, A. Agalias, D. Galaris, and S. Mitakou DNA protecting and genotoxic effects of olive oil related components in cells exposed to hydrogen peroxide Free Radic. Res. 39 2005 787 795
-
(2005)
Free Radic. Res.
, vol.39
, pp. 787-795
-
-
Nousis, L.1
Doulias, P.-T.2
Aligiannis, N.3
Bazios, D.4
Agalias, A.5
Galaris, D.6
Mitakou, S.7
-
40
-
-
0028833163
-
The kinetics of repair of oxidative DNA damage (strand breaks and oxidized pyrimidines) in human cells
-
A.R. Collins, A. Ma, and S.J. Duthie The kinetics of repair of oxidative DNA damage (strand breaks and oxidized pyrimidines) in human cells Mutat. Res. 336 1995 69 77
-
(1995)
Mutat. Res.
, vol.336
, pp. 69-77
-
-
Collins, A.R.1
Ma, A.2
Duthie, S.J.3
-
41
-
-
0031763502
-
DNA instability (strand breakage, uracil misincorporation and defective repair) is increased by folic acid depletion in human lymphocytes in vitro
-
S.J. Duthie, and A. Hawdon DNA instability (strand breakage, uracil misincorporation and defective repair) is increased by folic acid depletion in human lymphocytes in vitro FASEB J. 14 1998 1491 1497
-
(1998)
FASEB J.
, vol.14
, pp. 1491-1497
-
-
Duthie, S.J.1
Hawdon, A.2
-
42
-
-
0031570288
-
Fluorescence analysis of the labile iron pool of mammalian cells
-
S. Epsztejn, O. Kakhlon, H. Glickstein, W. Breuer, and Z.I. Cabantchik Fluorescence analysis of the labile iron pool of mammalian cells Anal. Biochem. 248 1997 31 40
-
(1997)
Anal. Biochem.
, vol.248
, pp. 31-40
-
-
Epsztejn, S.1
Kakhlon, O.2
Glickstein, H.3
Breuer, W.4
Cabantchik, Z.I.5
-
43
-
-
0028116941
-
Total antioxidant status in plasma and body fluids
-
C. Rice-Evans, and N.J. Miller Total antioxidant status in plasma and body fluids Methods Enzymol. 234 1994 279 293
-
(1994)
Methods Enzymol.
, vol.234
, pp. 279-293
-
-
Rice-Evans, C.1
Miller, N.J.2
-
44
-
-
0023905646
-
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro
-
J. Imlay, S. Chin, and S. Lim Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro Science 240 1988 640 642
-
(1988)
Science
, vol.240
, pp. 640-642
-
-
Imlay, J.1
Chin, S.2
Lim, S.3
-
45
-
-
0037139351
-
Comparative quantitative structure toxicity relationships for flavonoids evaluated in isolated rat hepatocytes and HeLa tumor cells
-
M.Y. Moridani, G. Galati, and P.J. O'Brien Comparative quantitative structure toxicity relationships for flavonoids evaluated in isolated rat hepatocytes and HeLa tumor cells Chem.-Biol. Interact. 139 2002 251 264
-
(2002)
Chem.-Biol. Interact.
, vol.139
, pp. 251-264
-
-
Moridani, M.Y.1
Galati, G.2
O'Brien, P.J.3
-
46
-
-
1542395634
-
Hydroxylation at C4′ or C6 is essential for apoptosis inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species
-
C.H. Ko, S.-C. Shen, and Y.C. Chen Hydroxylation at C4′ or C6 is essential for apoptosis inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species Free Radic. Biol. Med. 36 2004 897 910
-
(2004)
Free Radic. Biol. Med.
, vol.36
, pp. 897-910
-
-
Ko, C.H.1
Shen, S.-C.2
Chen, Y.C.3
-
47
-
-
17244379213
-
Stability of ferric complexes with 3-hydroxyflavone (flavonol), 5,7-dihydroxyflavone (chrysin), and 3′,4′-dihydroxyflavone
-
M.D. Engelmann, R. Hutcheson, and I.F. Cheng Stability of ferric complexes with 3-hydroxyflavone (flavonol), 5,7-dihydroxyflavone (chrysin), and 3′,4′-dihydroxyflavone J. Agric. Food Chem. 53 2005 2953 2960
-
(2005)
J. Agric. Food Chem.
, vol.53
, pp. 2953-2960
-
-
Engelmann, M.D.1
Hutcheson, R.2
Cheng, I.F.3
|