Hydrolysis of third-generation cephalosporins by class C β-lactamases: Structures of a transition state analog of cefotaxime in wild-type and extended spectrum enzymes

Journal of Biological Chemistry

Volumn 279, Issue 10, 2004, Pages 9344-9352

  Nukaga, Michiyoshi ^a   Kumar, Sanjai ^b   Nukaga, Hayoko ^a   Pratt, R F ^b   Knox, James R ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b WESLEYAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIOLOGY; CHEMICAL ACTIVATION; ENZYMES; HYDROLYSIS; PHOSPHORUS COMPOUNDS;

BACTERIAL RESISTANCE;

BIOCHEMISTRY;

3 NITROPHEYL 2 (2 AMINOTHIAZOL 4 YL) 2 (METHOXYIMINO)ACETYLAMINOMETHYLPHOSPHONATE; AMINOMETHYLPHOSPHONIC ACID; BETA LACTAMASE; CEFOTAXIME; CEFTAZIDIME; CEPHALOSPORIN; LIGAND; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CITROBACTER FREUNDII; CRYSTAL STRUCTURE; DEACYLATION; DRUG HYDROLYSIS; ENTEROBACTER CLOACAE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BETA-LACTAMASES; CEFOTAXIME; CEPHALOSPORIN RESISTANCE; CEPHALOSPORINS; CITROBACTER FREUNDII; ENTEROBACTER CLOACAE; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

ANIMALIA; BACTERIA (MICROORGANISMS); CITROBACTER; CITROBACTER FREUNDII; ENTEROBACTER; ENTEROBACTER CLOACAE; NEGIBACTERIA;

EID: 1542274594     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312356200     Document Type: Article

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