Centrosome amplification and multinuclear phenotypes are induced by hydrogen peroxide

Experimental and Molecular Medicine

Volumn 37, Issue 5, 2005, Pages 482-487

  Chae, Sunyoung ^a   Yun, Chawon ^b   Um, Haeryun ^a   Lee, Jae Ho ^a   Cho, Hyeseong ^a  

^a Ajou University School of Medicine   (South Korea)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Antioxidants; Centrosome; Giant cells; Hydrogen peroxide; Reactive oxygen species

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETYLCYSTEINE; ANTIOXIDANT; DOXORUBICIN; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL CYCLE; CENTROSOME; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CELL; MITOSIS; MULTINUCLEAR CELL; PHENOTYPE; SPINDLE CELL;

EID: 27744541402     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2005.59     Document Type: Article

References (25)

1. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev 1998;78:547-81
2. Bertwistle D, Ashworth A. The pathology of familial breast cancer: how do the functions of BRCA1 and BRCA2 relate to breast tumour pathology? Breast Cancer Res 1999;1:41-7
3. Blasco MA. Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging. EMBO J 2005;24:1095-103
4. Childs AC, Phaneuf SL, Dirks AJ, Phillips T, Leeuwenburgh C. Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio. Cancer Res 2002;62:4592-8
5. D'Assoro AB, Lingle WL, Salisbury JL. Centrosome amplification and the development of cancer. Oncogene 2002;21:6146-53
6. Deepa PR, Varalakshmi P. Protective effect of low molecular weight heparin on oxidative injury and cellular abnormalities in adriamycin-induced cardiac and hepatic toxicity. Chem Biol Interact 2003;146:201-10
7. Devaney K, Goodman ZD, Ishak KG. Postinfantile giant-cell transformation in hepatitis. Hepatology 1992;24:737-45
8. Evans HL. Multinucleated giant cells in plantar fibromatosis. Am J Surg Pathol 2002;26:244-8
9. Hutter E, Unterluggauer H, Uberall F, Schramek H, Jansen-Durr P. Replicative senescence of human fibroblasts: the role of Ras-dependent signaling and oxidative stress. Exp Gerontol 2002;37:1165-74
10. Jeng YM, Peng SY, Lin CY, Hsu HC. Overexpression and amplification of Aurora-A in hepatocellular carcinoma. Clin Cancer Res 2004;10:2065-71
11. Kawamura K, Izumi H, Ma Z, Ikeda R, Moriyama M, Tanaka T, Nojima T, Levin LS, Fujikawa-Yamamoto K, Suzuki K, Fukasawa K. Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression. Cancer Res 2004;64:4800-9
12. Kim MR, Kim HS, Lee MS, Lee MJ, Jang JJ. Cell cycle protein profile of the hepatic stellate cells (HSCs) in dimethylnitrosamine-induced rat hepatic fibrosis. Exp Mol Med 2005;37:335-42
13. Lange BM. Integration of the centrosome in cell cycle control, stress response and signal transduction pathways. Curr Opin Cell Biol 2002;14:35-43
14. Leonard SS, Harris GK, Shi X. Metal-induced oxidative stress and signal transduction. Free Radic Bio Med 2004;37:1921-42
15. Mattson MP. Gene-diet interactions in brain aging and neurodegenerative disorders. Ann Intern Med 2003;139:441-4
16. Park M, Park H, Kim WH, Cho J, Lee JH. Presence of autocrine hepatocyte growth factor-Met signaling and its role in proliferation and migration of SNU-484 gastric cancer cell line. Exp Mol Med 2005;37:213-9
17. Protzer U, Dienes HP, Bianchi L, Lohse AW, Helmreich-Becker I, Gerken G, Meyer zum Buschenfelde KH. Post-infantile giant cell hepatitis in patients with primary sclerosing cholangitis and autoimmune hepatitis. Liver 1996;16:274-82
18. Ren R, Sun X, Staerkel G, Sneige N, Gong Y. Fine-needle aspiration cytology of a liver metastasis of follicular dendritic cell sarcoma. Diagn Cytopathol. 2005;32:38-43
19. Rodier F, Kim SH, Nijjar T, Yaswen P, Campisi J. Cancer and aging: the importance of telomeres in genome maintenance. Int J Biochem Cell Biol 2005;37:977-90
20. Saavedra HI, Fukasawa K, Conn CW, Stambrook PJ. MAPK mediates RAS-induced chromosome instability. J Biol Chem 1999;274:38083-90
21. Sathasivam K, Woodman B, Mahal A, Bertaux F, Wanker EE, Shima DT, Bates GP. Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients. Hum Mol Genet 2001;10:2425-35
22. Satyanarayana A, Manns MP, Rudolph KL. Telomeres and telomerase: a dual role in hepatocarcinogenesis. Hepatology 2004;40:276-83
23. Schatten H, Chakrabarti A, Hedrick J. Centrosome and microtubule instability in aging Drosophila cells. J Cell Biochem 1999;74:229-41
24. Wang JH, Yun C, Kim S, Lee JH, Yoon G, Lee MO, Cho H. Reactive oxygen species modulates the intracellular level of HBx viral oncoprotein. Biochem Biophys Res Commun 2003;310:32-9
25. Yun C, Cho H, Kim SJ, Lee JH, Park SY, Chan GK, Cho H. Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway. Mol Cancer Res 2004;2:159-69