Death of an axon: Studying axon loss in development and disease

Histochemistry and Cell Biology

Volumn 124, Issue 3-4, 2005, Pages 189-196

  Misgeld, Thomas ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Axon loss; Degeneration; In vivo imaging; Neuromuscular junction; Spinal cord injury

Indexed keywords

CONFERENCE PAPER; CYTOSKELETON; IMAGING SYSTEM; NERVE CELL NECROSIS; NERVE DEGENERATION; NERVE FIBER; NERVE FIBER DEGENERATION; NERVE FIBER GROWTH; NERVE FIBER TRANSECTION; NERVE FIBER TRANSPORT; NERVOUS SYSTEM DEVELOPMENT; NEUROLOGIC DISEASE; NEUROMUSCULAR FUNCTION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; SCHWANN CELL; SPINAL CORD INJURY; SYNAPSE; SYNAPSE VESICLE;

ANIMALS; AXONS; CELL DEATH; HUMANS; MICE; NERVE DEGENERATION; NEUROMUSCULAR JUNCTION; SCHWANN CELLS; SPINAL CORD INJURIES; SYNAPSES; WALLERIAN DEGENERATION;

WALLERIA;

EID: 27744516846     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-005-0036-6     Document Type: Conference Paper

References (71)

1. Araki T, Sasaki Y, Milbrandt J (2004) Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305:1010-1013
2. Bastmeyer M, O'Leary DD (1996) Dynamics of target recognition by interstitial axon branching along developing cortical axons. J Neurosci 16:1450-1459
3. Beirowski B, Adalbert R, Wagner D, Grumme DS, Addicks K, Ribchester RR, Coleman MP (2005) The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves. BMC Neurosci 6:6
4. Beirowski B, Berek L, Adalbert R, Wagner D, Grumme DS, Addicks K, Ribchester RR, Coleman MP (2004) Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice. J Neurosci Methods 134:23-35
5. Bernstein M, Lichtman JW (1999) Axonal atrophy: the retraction reaction. Curr Opin Neurobiol 9:364-370
6. Bishop DL, Misgeld T, Walsh MK, Gan WB, Lichtman JW (2004) Axon branch removal at developing synapses by axosome shedding. Neuron 44:651-661
7. Buffelli M, Burgess RW, Feng G, Lobe CG, Lichtman JW, Sanes JR (2003) Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition. Nature 424:430-434
8. Caroni P (1997) Overexpression of growth-associated proteins in the neurons of adult transgenic mice. J Neurosci Methods 71:3-9
9. Chen BE, Lendvai B, Nimchinsky EA, Burbach B, Fox K, Svoboda K (2000) Imaging high-resolution structure of GFP-expressing neurons in neocortex in vivo. Learn Mem 7:433-441
10. Coleman MP, Perry VH (2002) Axon pathology in neurological disease: a neglected therapeutic target. Trends Neurosci 25:532-537
11. Cowan WM, Fawcett JW, O'Leary DD, Stanfield BB (1984) Regressive events in neurogenesis. Science 225:1258-1265
12. Deckwerth TL, Johnson EM Jr (1994) Neurites can remain viable after destruction of the neuronal soma by programmed cell death (apoptosis). Dev Biol 165:63-72
13. Denk W, Svoboda K (1997) Photon upmanship: why multiphoton imaging is more than a gimmick. Neuron 18:351-357
14. Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W, Geuze HJ (2000) Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci 113(Pt 19):3365-3374
15. DePaola V, Arber S, Caroni P (2003) AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks. Nat Neurosci 6:491-500
16. Edinger AL, Thompson CB (2004) Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 16:663-669
17. Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, Wallace M, Nerbonne JM, Lichtman JW, Sanes JR (2000) Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28:41-51
18. Ferri A, Sanes JR, Coleman MP, Cunningham JM, Kato AC (2003) Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease. Curr Biol 13:669-673
19. Fischer LR, Culver DG, Davis AA, Tennant P, Wang M, Coleman M, Asress S, Adalbert R, Alexander GM, Glass JD (2005) The Wld(S) gene modestly prolongs survival in the SOD1G93A fALS mouse. Neurobiol Dis 19:293-300
20. Gan WB, Bishop DL, Turney SG, Lichtman JW (1999) Vital imaging and ultrastructural analysis of individual axon terminals labeled by iontophoretic application of lipophilic dye. J Neurosci Methods 93:13-20
21. Gan WB, Kwon E, Feng G, Sanes JR, Lichtman JW (2003) Synaptic dynamism measured over minutes to months: age-dependent decline in an autonomic ganglion. Nat Neurosci 6:956-960
22. Gillingwater TH, Haley JE, Ribchester RR, Horsburgh K (2004) Neuroprotection after transient global cerebral ischemia in Wld(s) mutant mice. J Cereb Blood Flow Metab 24:62-66
23. Gillingwater TH, Ribchester RR (2001) Compartmental neurodegeneration and synaptic plasticity in the Wld(s) mutant mouse. J Physiol 534:627-639
24. Grutzendler J, Kasthuri N, Gan WB (2002) Long-term dendritic spine stability in the adult cortex. Nature 420:812-816
25. Jacob JE, Gris P, Fehlings MG, Weaver LC, Brown A (2003) Autonomic dysreflexia after spinal cord transection or compression in 129 Sv, C57BL, and Wallerian degeneration slow mutant mice. Exp Neurol 183:136-146
26. Jacob JM, Zhou Q, Liu Y (2000) Novel method for the labeling of distant neuromuscular junctions. J Neurosci Res 61:61-66
27. Jacobson MD, Weil M, Raff MC (1997) Programmed cell death in animal development. Cell 88:347-354
28. Jefferis GS, Marin EC, Watts RJ, Luo L (2002) Development of neuronal connectivity in Drosophila antennal lobes and mushroom bodies. Curr Opin Neurobiol 12:80-86
29. Kasthuri N, Lichtman JW (2003) The role of neuronal identity in synaptic competition. Nature 424:426-430
30. Keller-Peck CR, Walsh MK, Gan WB, Feng G, Sanes JR, Lichtman JW (2001) Asynchronous synapse elimination in neonatal motor units: studies using GFP transgenic mice. Neuron 31:381-394
31. Kerschensteiner M, Schwab ME, Lichtman JW, Misgeld T (2005) In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat Med 11:572-577
32. Kornek B, Lassmann H (1999) Axonal pathology in multiple sclerosis. A historical note. Brain Pathol 9:651-656
33. Lichtman JW, Colman H (2000) Synapse elimination and indelible memory. Neuron 25:269-278
34. Lichtman JW, Fraser SE (2001) The neuronal naturalist: watching neurons in their native habitat. Nat Neurosci 4(Suppl):1215-1220
35. Lichtman JW, Sanes JR (2003) Watching the neuromuscular junction. J Neurocytol 32:767-775
36. Lunn ER, Perry VH, Brown MC, Rosen H, Gordon S (1989) Absence of Wallerian Degeneration does not hinder regeneration in peripheral nerve. Eur J Neurosci 1:27-33
37. Luo L, O'Leary DD (2005) Axon retraction and degeneration in development and disease. Annu Rev Neurosci 28:127-156
38. Mack TG, Reiner M, Beirowski B, Mi W, Emanuelli M, Wagner D, Thomson D, Gillingwater T, Court F, Conforti L, Fernando FS, Tarlton A, Andressen C, Addicks K, Magni G, Ribchester RR, Perry VH, Coleman MP (2001) Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat Neurosci 4:1199-1206
39. Magrassi L, Purves D, Lichtman JW (1987) Fluorescent probes that stain living nerve terminals. J Neurosci 7:1207-1214
40. Mi W, Beirowski B, Gillingwater TH, Adalbert R, Wagner D, Grumme D, Osaka H, Conforti L, Arnhold S, Addicks K, Wada K, Ribchester RR, Coleman MP (2005) The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice. Brain 128:405-416
41. Nakamura H, O'Leary DD (1989) Inaccuracies in initial growth and arborization of chick retinotectal axons followed by course corrections and axon remodeling to develop topographic order. J Neurosci 9:3776-3795
42. Nguyen QT, Sanes JR, Lichtman JW (2002) Pre-existing pathways promote precise projection patterns. Nat Neurosci 5:861-867
43. Oppenheim RW (1991) Cell death during development of the nervous system. Annu Rev Neurosci 14:453-501
44. Pan YA, Misgeld T, Lichtman JW, Sanes JR (2003) Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo. J Neurosci 23:11479-11488
45. Perry VH, Brown MC, Lunn ER (1991) Very slow retrograde and Wallerian degeneration in the CNS of C57BL/Ola mice. Eur J Neurosci 3:102-105
46. Perry VH, Lunn ER, Brown MC, Cahusac S, Gordon S (1990) Evidence that the rate of Wallerian degeneration is controlled by a single autosomal dominant gene. Eur J Neurosci 2:408-413
47. Purves D, Lichtman JW (1980) Elimination of synapses in the developing nervous system. Science 210:153-157
48. Raff MC, Barres BA, Burne JF, Coles HS, Ishizaki Y, Jacobson MD (1993) Programmed cell death and the control of cell survival: lessons from the nervous system. Science 262:695-700
49. Raff MC, Whitmore AV, Finn JT (2002) Axonal self-destruction and neurodegeneration. Science 296:868-871
50. Ramon y Cajal S (1928) Degeneration and regeneration of the nervous system. In: DeFelipe J, Jones EG (eds) Cajal's degeneration and regeneration of the nervous system. Oxford University Press, Oxford
51. Reyes R, Haendel M, Grant D, Melancon E, Eisen JS (2004) Slow degeneration of zebrafish Rohon-Beard neurons during programmed cell death. Dev Dyn 229:30-41
52. Riley DA (1981) Ultrastructural evidence for axon retraction during the spontaneous elimination of polyneuronal innervation of the rat soleus muscle. J Neurocytol 10:425-440
53. Rosenthal JL, Taraskevich PS (1977) Reduction of multiaxonal innervation at the neuromuscular junction of the rat during development. J Physiol 270:299-310
54. Sabbatini RME (2003) Neurons and synapses - the history of its discovery. Brain and Mind. http://www.cerebromente.org.br/n17/history/neurons1_i.htm
55. Sajadi A, Schneider BL, Aebischer P (2004) Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease. Curr Biol 14:326-330
56. Samsam M, Mi W, Wessig C, Zielasek J, Toyka KV, Coleman MP, Martini R (2003) The Wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy. J Neurosci 23:2833-2839
57. Sanes JR, Lichtman JW (1999) Development of the vertebrate neuromuscular junction. Annu Rev Neurosci 22:389-442
58. Svoboda KR, Linares AE, Ribera AB (2001) Activity regulates programmed cell death of zebrafish Rohon-Beard neurons. Development 128:3511-3520
59. Tom VJ, Steinmetz MP, Miller JH, Doller CM, Silver J (2004) Studies on the development and behavior of the dystrophic growth cone, the hallmark of regeneration failure, in an in vitro model of the glial scar and after spinal cord injury. J Neurosci 24:6531-6539
60. Trachtenberg JT, Chen BE, Knott GW, Feng G, Sanes JR, Welker E, Svoboda K (2002) Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature 420:788-794
61. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L (1998) Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338:278-285
62. Vande VC, Garcia ML, Yin X, Trapp BD, Cleveland DW (2004) The neuroprotective factor Wlds does not attenuate mutant SOD1-mediated motor neuron disease. Neuromol Med 5:193-203
63. Walsh MK, Lichtman JW (2003) In vivo time-lapse imaging of synaptic takeover associated with naturally occurring synapse elimination. Neuron 37:67-73
64. Walsh MK, Lichtman JW (2005) Imaging the development of neuromuscular junctions. In: Yuste R, Konnerth A (eds) Imaging in neuroscience and development: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 215-224
65. Wang M, Wu Y, Culver DG, Glass JD (2001) The gene for slow Wallerian degeneration (Wld(s)) is also protective against vincristine neuropathy. Neurobiol Dis 8:155-161
66. Watts RJ, Hoopfer ED, Luo L (2003) Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system. Neuron 38:871-885
67. Watts RJ, Schuldiner O, Perrino J, Larsen C, Luo L (2004) Glia engulf degenerating axons during developmental axon pruning. Curr Biol 14:678-684
68. Williams PL, Hall SM (1970) In vivo observations on mature myelinated nerve fibres of the mouse. J Anat 107:31-38
69. Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z (2003) Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron 39:217-225
70. Zong H, Espinosa JS, Su HH, Muzumdar MD, Luo L (2005) Mosaic analysis with double markers in mice. Cell 121:479-492
71. Zuo Y, Lubischer JL, Kang H, Tian L, Mikesh M, Marks A, Scofield VL, Maika S, Newman C, Krieg P, Thompson WJ (2004) Fluorescent proteins expressed in mouse transgenic lines mark subsets of glia, neurons, macrophages, and dendritic cells for vital examination. J Neurosci 24:1099-1100