GSH transporters: Molecular characterization role in GSH homeostasis

Biological Chemistry Hoppe-Seyler

Volumn 377, Issue 5, 1996, Pages 267-273

  Kaplowitz, Neil ^a   Jose C ^a   Fernandez Checa ^b   Kannan, Ramswamy ^a   Garcia Ruiz, Carmen ^b   Ookhtens, Murad ^a   Yi, Jian Ru ^a  

^a DSC School of Medicine   (United States)

^b HOSPITAL CLÍNIC   (Spain)

Author keywords

Antioxidantdefense; Canalicular; Cysteine; Expression cloning; Liver; Sinusoidal

Indexed keywords

CARRIER PROTEIN; CYSTEINE; GLUTATHIONE; LIVER PROTEIN;

AMINO ACID TRANSPORT; ARTICLE; HOMEOSTASIS; MITOCHONDRION; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SYNTHESIS REGULATION; PROTEIN TRANSPORT;

ANIMALS; CARRIER PROTEINS; GLUTATHIONE; HOMEOSTASIS; HUMANS; LIVER; MEMBRANE TRANSPORT PROTEINS;

EID: 0030036320     PISSN: 01773593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Aw, T.Y. (1994). Biliary glutathione promotes the mucosal metabolism of luminal peroxidized lipids by rat small intestine in vivo. J. Clin. Invest. 94, 1218-1225.
2. Aw, T.Y., Ookhtens, M., Kaplowitz, N. (1984). Inhibition of glutathione efflux from isolated hepatocytes by methionine. J. Biol. Chem.259, 9355-9358.
3. Aw, T.Y., Ookhtens, M., Kaplowitz, N. (1986a). Mechanism of inhibition of glutathione efflux from isolated hepatocytes by methionine. Am. J. Physiol. 251, G354 - G361.
4. Aw, T.Y., Ookhtens, M., Ren, C., Kaplowitz, N. (1986b). Kinetics of GSH efflux from freshly isolated rat hepatocytes. Am. J. Physiol. 250, G236 - G243.
5. Aw, T.Y, Ookhtens, M., Kuhlenkamp, J., Kaplowitz, N. (1987). Transstimulation driving forces for GSH transport in sinusoidal membrane vesicles from rat liver. Biochem. Biophys. Res. Commun. 743, 377-382.
6. Ballatori, N., Clarkson, T.W. (1982). Developmental changes in the biliary excretion of methylmercury glutathione. Science 276, G1-G3.
7. Ballatori, N., Dutczak, W.J. (1994). Identification characterization of high low affinity transport for reduced glutathione in liver cell canalicular membranes. J. Biol. Chem. 267, 19731-19737.
8. Ballatori, N., Truong, A. (1989). Relation between biliary glutathione excretion bile acid independent bile flow. Am. J. Physiol. 256, G22-G30.
9. Bartoli, G.M., Sies, H. (1978). Reduced oxidized glutathione efflux from liver. FEBS lett. 59, 89 - 91.
10. Eberle, D., Clarke, R., Kaplowitz, N. (1981 ). Rapid oxidation in vitro of glutathione in bile. J. Biol. Chem. 256, 2115-2117.
11. Fernández-Checa, J. Ookhtens, M., Kaplowitz, N. (1987). Effect of chronic ethanol feeding on rat hepatocytic glutathione: compartmentation, efflux response to incubation with ethanol. J. Clin. Invest. 80, 57-62.
12. Fernández-Checa, J., Ren, C., Aw, T.Y, Ookhtens, M., Kaplowitz, N. (1988). Effect of membrane potential cellular ATP on GSH efflux from isolated rat hepatocytes. Am. J. Physiol. 78, G403-G408.
13. Fernández-Checa, J., Ookhtens, M., Kaplowitz, N. (1989). Effects of chronic ethanol feeding on rat hepatocytic glutathione: relationship of cytosolic GSH to efflux mitochondrial sequestration. J. Clin. Invest. 83, 1247 -1252.
14. Fernández-Checa, J., Ookhtens, M., Kaplowitz, N. (1990). Effect of GSH synthesis on the inhibition of GSH efflux by methionine: studies in isolated hepatocytes perfused liver. Am. J. Physiol. 258, G967 - G973.
15. Fernández-Checa, J., Garcia-Ruiz, C., Ookhtens, M., Kaplowitz, N. (1991). Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-f ed rats: tracer kinetic studies in vitro in vivo susceptibility to oxidant stress. J. Clin. Invest. 87, 397- 405.
16. Fernández-Checa, J., Takikawa, H., Ookhtens, M., Kaplowitz, N. (1992). Canalicular transport of GSH in normal EHBR mutant rats. J. Biol. Chem. 267, 1667 -1673.
17. Fernández-Checa, J., Ookhtens, M., Kaplowitz, N. (1993a). Selective induction by phénobarbital of the electrogenic transport of GSH organic anions in rat liver canalicular membrane vesicles. J. Biol. Chem. 268, 10836 -10841.
18. Fernández-Checa, J., Yi, J., Garcia-Ruiz, C., Knezic, Z., Tahara, S., Kaplowitz, N. (1993b). Expression of rat liver GSH transport in Xenopus laevis oocytes. J. Biol. Chem. 268, 2324-2328.
19. Fernández-Checa, J., Garcia-Ruiz, C., Colell, A., Yi, J., Kaplowitz, N. (1996). Inhibition of rat sinusoidal GSH transport by Thioethers: specificity, sidedness kinetics. Am. J. Physiol., in press.
20. Garcia-Ruiz, C., Fernández-Checa, J., Kaplowitz, N. (1992). Bidirectional mechanism of plasma membrane transport of reduced GSH in hepatocytes membrane vesicles. J. Biol. Chem. 267, 22256 -22264.
21. Garcia-Ruiz, C., Morales, A., Ballesta, A., Rodes, J., Kaplowitz, N., Fernández-Checa, J. (1994). Effect of chronic ethanol feeding on glutathione functional integrity of mitochondria in periportal perivenous rat hepatocytes. J. Clin. Invest. 94, 193-201.
22. Garcia-Ruiz, C., Morales, A., Colell, A., Yi, J., Rodes, J., Kaplowitz, N., Fernández-Checa, J. (1995). Evidence that the rat hepatic mitochondria! carrier for reduced glutathione is distinct from the sinusoidal canalicular transporters: expression studies in Xenopus laevis oocytes. J. Biol. Chem. 270, 15946-15949.
23. Hagen, T.M., Brown, L.A., Jones, O.P. (1986). Protection against paraquat-induced injury by exogenous GSH in pulmonary alveolar type II cells. Biochem. Pharm. 353, 4537 - 4542.
24. Hill, K.E., Burk, R.F. (1982). Effect of selenium deficiency vitamin E deficiency on glutathione metabolism in isolated rat hepatocytes. J. Biol. Chem. 257, 10668 -10672.
25. Hirano, T., Kaplowitz, N., Tsukamoto, H., Kamimura, S., Fernández-Checa, J. (1992). Hepatic mitochondrial GSH depletion progression of experimental alcoholic liver disease. Hepatology 76, 1423-1427.
26. Inoue, M., Kinne, R., Tran, T., Arias, l.M. (1983). The mechanism of biliary secretion of reduced glutathione: analysis of transport process in isolated rat-liver canalicular membrane vesicles. Eur. J. Biochem. 134, 467 - 471.
27. Inoue, M., Kinne, R., Tran, T., Arias, I.M. (1984). Glutathione transport across hepatocyte plasma membranes: analysis using isolated rat-liver sinusoidal vesicles. Eur. J. Biochem. 738, 491-495.
28. Kannan, R., Kuhlenkamp, J., Jeidier, E.., Trinh, H., Ookhtens, M., Kaplowitz, N. (1990). Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat. J. Clin. Invest. 85, 2009 - 2013.
29. Kannan, R., Kuhlenkamp, J., Ookhtens, M., Kaplowitz, N. (1992). Transport of GSH at the blood-brain barrier of the rat: inhibition age-dependence. J. Pharm. Exp. Therap. 263, 964-970.
30. Kannan, R., Yi, J., Zlokovic, B., Kaplowitz, N. (1995). Molecular characterization of a reduced glutathione transporter in the lens. Invest. Ophthalmol. Vis. Sci. 36, 1785 -1792.
31. Kannan, R., Yi, J., Tang, D., Li, Y., Zlokovic, B., Kaplowitz, N. (1996). Evidence for the existence of a sodium dependent GSH transporter: Expression of bovine brain capillary mRNA in Xenopus laevis oocytes dissociation from gamma-glutamyl transpeptidase facilitative GSH transporters J. Biol. Chem. 277, 9754-9758.
32. Kaplowitz, N., Eberle, D., Petrini, J., Touloukian, J., Kuhlenkamp, J. (1983). Factors influencing the efflux of GSH into bile in the rat. J. Pharm. Exp. Therap. 224, 141 -147.
33. Kaplowitz, N., Ookhtens, M., Lu, S. (1995). Sinusoidal efflux of hepatic GSH: significance, physiology, regulation. In: Bithiols, L. Packer E. Cadenas, eds. (New York: Marcel Dekker, Inc.), pp. 213 - 229.
34. Lash, L.H., Hagen, T.M., Jones, D.P. (1986). Exogenous glutathione protects intestinal epithelial cells from oxidative injury. Proc. Natl. Acad. Sci. USA 83, 4641 -4645.
35. Lash, L.H., Jones, D.P. (1984). Renal glutathione transport: Characteristics of the sodium-dependent system in the basallateral membrane. J. Biol. Chem. 259, 14508 -14514.
36. Leier, I-, Jedlitschky, G., Buchholz, U., Cole, S., Deeley, R.G., Keppler, D. (1994). The MRP gene encodes an ATP- dependent export pump for leukotriene C4 structurally related conjugates. J. Biol. Chem. 269, 27807 - 27810.
37. Lu, S., Garcia-Ruiz, C., Kuhlenkamp, J., Ookhtens, M., SalasPrato, M., Kaplowitz, N. (1990). Hormonal regulation of hepatic GSH efflux. Studies in cultured rat hepatocytes perfused liver. J. Biol. Chem. 265, 16088 -16095.
38. Lu, S., Ge, J.-L, Huang, H.-Y, Kuhlenkamp, J., Kaplowitz, N. (1993). Thiol-disulfide effects on hepatic GSH transport. Studies in cultured rat hepatocytes perfused livers. J. Clin. Invest. 92, 1188-1197.
39. Lu, S., Kuhlenkamp, J., Ge, J.-L, Wei-Min, S., Kaplowitz, N.(1994). Specificity directionality of Thiol effects on sinusoidal GSH transport in rat liver. Mol. Pharm. 46, 578-585.
40. Lu, S., Kuhlenkamp, J., Wu, H., Sun, W.-M., Stone, L, Yi, J., Kaplowitz, N. (1996a). Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats. Am. J. Physiol., in press.
41. Lu, S., Sun, W.-M., Yi, J., Ookhtens, M., Kaplowitz, N. (1996b). Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH in mammalian cells. J. Clin. Invest. 97, 1488-1496.
42. Mackic, J., Jinagouda, S., McComb, J., Weiss, M., Kannan, R., Kaplowitz, N., Zlokovic, B. (1996). Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance manipulations. Exp. Eye Res., 62, 29-37.
43. Martensson, J., Lai, C.K., Meister, A. (1990). High affinity transport of GSH is part of multicomponent system essential for mitochondria function. Proc. Natl. Acad. Sci. USA 87, 7185-7189.
44. Meredith, M., Reed, D. (1982). Status of the mitochondria! pool of glutathione in the isolated hepatocyte. J. Biol. Chem. 257, 3747-3753.
45. Ookhtens, M., Maddatu, T. (1991). Mechanism of changes in hepatic sinusoidal biliary glutathione efflux with age in rats. Am. J. Physiol. 267, G648 - G656.
46. Ookhtens, M., Mittur, A.V. (1994). Developmental changes in plasma Thiol-disulfide turnover in rats: a multicompartmental approach. Am. J. Physiol. 267, R415 - R425.
47. Ookhtens, M., Corvasce, C., Hobdy, K., Aw, T.Y., Kaplowitz, N. (1985). Sinusoidal efflux of glutathione in the perfused rat liver. J. Clin. Invest. 75, 258-265.
48. Ookhtens, M., Fernández-Checa, J., Lyon, I., Kaplowitz, N. (1988). Inhibition of GSH efflux in the perfused rat liver isolated hepatocytes by organic anions bilirubin: kinetics, sidedness molecular forms. J. Clin. Invest. 82, 608 - 616.
49. Ookhtens, M., Mittur, A.V., Erhart, N.A. (1994). Changes in plasma glutathione concentrations, turnover disposal in developing rats. Am. J. Physiol. 266, R979 - R988.
50. Raiford, D.S., Scuito, A.M., Mitchell, M.C. (1991). Effects of vasopressor hormones modulators of protein kinase C on glutathione efflux from perfused rat liver. Am. J. Physiol. 261, G578-G584.
51. Sato, C., Liu, J.H., Tang, L, Sakai, Y, Yauehi, T., Izumi, N., Liu, J., Takano, T., Marimo, F. (1992). Possible involvement of protein kinase C calcium in GSH efflux from Hep G2 cells. Life Sci. 57, 2057-2063.
52. Sies, H., Graf, P. (1985). Hepatic Thiol glutathione efflux underthe influence of vasopressin, phenylephrine adrenaline. Biochem. J. 226, 545 - 549.
53. Speisky, H., Shackel, N., Varghese, A., Wade, D., Israel, Y (1990). Role of hepatic gamma-glutamyltransferase in the degradation of circulating glutathione. Hepatology. 11, 843 849.
54. Yi, J., Lu, S., Fernández-Checa, J., Kaplowitz, N. (1994). Expression cloning of a rat hepatic reduced glutathione transporter with canalicular characteristics. J. Clin. Invest. 93, 1841-1845.
55. Yi, J., Lu, S., Fernández-Checa, J., Kaplowitz, N. (1995). Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics comparison with the canalicular transporter. Proc. Nathl. Acad. Sci. USA 92, 1495 -1499.
56. Zaman, G., Lankelma, J., van Teilingen, O., Beijnens, J., Dekker, H., Paulusma, C., Oude Elferink, R., Baas, F., Borst, R (1995). Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated proteins. Proc. Natl. Acad. Sci. USA 92, 7690 - 7694.
57. Zlokovic, B., Mackic, J., McComb, J., Kaplowitz, N., Weiss, M., Kannan, R. (1994a). Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye. Exp. Eye Res. 59, 487-496.
58. Zlokovic, B., Mackic, J., McCombs, G., Weiss, M., Kaplowitz, N., Kannan, R. (1994b). Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem. Biophys. Res. Commun. 207, 402-408.