A novel role of p38α MAPK in mitotic progression independent of its kinase activity

Cell Cycle

Volumn 4, Issue 11, 2005, Pages 1614-1622

  Fan, Li ^a   Yang, Xianlin ^a,b   Du, Jian ^a   Marshall, Mark ^a   Blanchard, Kerry ^a   Ye, Xiang ^a  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Cell cycle; Checkpoint control; p38 ; siRNA and kinase inhibitor

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOSIS; MOUSE; NONHUMAN; REGULATORY MECHANISM; RNA INTERFERENCE;

ANIMALIA;

EID: 27744493551     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001; 410:37-40.
2. Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 2004; 68:320-44.
3. Ono K, Han J. The p38 signal transduction pathway: Activation and function. Cell Signal 2000; 12:1-13.
4. Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science 2002; 295:1291-4.
5. Salvador JM, Mittelstadt PR, Guszczynski T, Copeland TD, Yamaguchi H, Appella E, Fornace Jr AJ, Ashwell JD. Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol 2005; 6:390-5.
6. Fearns C, Kline L, Gram H, Di Padova F, Zurini M, Han J, Ulevitch RJ. Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli. J Leukoc Biol 2000; 67:705-11.
7. Kumar S, Boehm J, Lee JC. p38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2003; 2:717-26.
8. Allen M, Svensson L, Roach M, Hambor J, McNeish J, Gabel CA. Deficiency of the stress kinase p38alpha results in embryonic lethality: Characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med 2000; 191:859-70.
9. Campbell J, Ciesielski CJ, Hunt AE, Horwood NJ, Beech JT, Hayes LA, Denys A, Feldmann M, Brennan FM, Foxwell BM. A novel mechanism for TNF-alpha regulation by p38 MAPK: Involvement of NF-kappa B with implications for therapy in rheumatoid arthritis. J Immunol 2004; 173:6928-37.
10. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, Lee JC. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 1995; 364:229-33.
11. Kotlyarov A, Neininger A, Schubert C, Eckert R, Birchmeier C, Volk HD, Gaestel M. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat Cell Biol 1999; 1:94-7.
12. Saklatvala J. The p38 MAP kinase pathway as a therapeutic target in inflammatory disease. Curr Opin Pharmacol 2004; 4:372-7.
13. Bulavin DV, Amundson SA, Fornace AJ. p38 and Chk1 kinases: Different conductors for the G(2)/M checkpoint symphony. Curr Opin Genet Dev 2002; 12:92-7.
14. Harris SL, Levine AJ. The p53 pathway: Positive and negative feedback loops. Oncogene 2005; 24:2899-908.
15. 2/M transition by triggering the p38 MAPK checkpoint pathway. J Cell Biol 2004; 166:517-26.
16. Shiozaki K, Russell P. Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Nature 1995; 378:739-43.
17. 2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 2001; 411:102-7.
18. 2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase. Proc Natl Acad Sci USA 2002; 99:184-9.
19. 2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol Cell Biol 2003; 23:8306-15.
20. 2/M transition and S phase progression in response to UV irradiation. Mol Cell 2005; 17:37-48.
21. Mikhailov A, Shinohara M, Rieder CL. The p38-mediated stress-activated checkpoint. A rapid response system for delaying progression through antephase and entry into mitosis. Cell Cycle 2005; 4:57-62.
22. Takenaka K, Moriguchi T, Nishida E. Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest. Science 1998; 280:599-602.
23. Jackman J, O'Connor PM. Methods for synchronizing cells at specific stages of the cell cycle. In: Bonifacino JS et al, eds. Current Protocols in Cell Biology. John Wiley and Sons Inc., 2004:8.3.11.
24. Ye XS, Xu G, Fincher RR, Osmani SA. Characterization of NIMA protein kinase in Aspergillus nidulans. Methods Enzymol 1997; 283:520-32.
25. Yang H, Burke T, Dempsey J, Diaz B, Collins E, Toth J, Beckmann R, Ye X. Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase. FEBS Lett 2005; 579:3385-91.
26. Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda AR. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 2000; 6:109-16.
27. Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S, Shen MM. Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci USA 2000; 97:10454-9.
28. Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M. Requirement for p38alpha in erythropoietin expression: A role for stress kinases in erythropoiesis. Cell 2000; 102:221-31.
29. Cheung PC, Campbell DG, Nebreda AR, Cohen P. Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. EMBO J 2003; 22:5793-805.
30. Zervos AS, Faccio L, Gatto JP, Kyriakis JM, Brent R. Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein. Proc Natl Acad Sci USA 1995; 92:10531-4.
31. Cook JG, Bardwell L, Thorner J. Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway. Nature 1997; 390:85-8.
32. Madhani HD, Styles CA, Fink GR. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 1997; 91:673-84.
33. Brancho D, Tanaka N, Jaeschke A, Ventura JJ, Kelkar N, Tanaka Y, Kyuuma M, Takeshita T, Flavell RA, Davis RJ. Mechanism of p38 MAP kinase activation in vivo. Genes Dev 2003; 17:1969-78.
34. Kelkar N, Standen CL, Davis RJ. Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol Cell Biol 2005; 25:2733-43.
35. Lee CM, Onesime D, Reddy CD, Dhanasekaran N, Reddy EP. JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Proc Natl Acad Sci USA 2002; 99:14189-94.
36. Ehrenreiter K, Piazzolla D, Velamoor V, Sobczak I, Small JV, Takeda J, Leung T, Baccarini M. Raf-1 regulates Rho signaling and cell migration. J Cell Biol 2005; 168:955-64.
37. Ewald JA, Wilkinson JC, Guyer CA, Staros JV. Ligand- and kinase activity-independent cell survival mediated by the epidermal growth factor receptor expressed in 32D cells. Exp Cell Res 2003; 282:121-31.
38. Lu C, Wang A, Dorsch M, Tian J, Nagashima K, Coyle AJ, Jaffee B, Ocain TD, Xu Y. Participation of Rip2 in lipopolysaccharide signaling is independent of its kinase activity. J Biol Chem 2005; 280:16278-83.
39. Yu VP, Baskerville C, Grunenfelder B, Reed SI. A kinase-independent function of Cks1 and Cdk1 in regulation of transcription. Mol Cell 2005; 17:145-51.
40. Han J, Lee JD, Bibbs L, Ulevitch RJ. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994; 265:808-11.
41. Campos CB, Bedard PA, Linden R. Activation of p38 mitogen-activated protein kinase during normal mitosis in the developing retina. Neuroscience 2002; 112:583-91.
42. Villa-Diaz LG, Miyano T. Activation of p38 MAPK during porcine oocyte maturation. Biol Reprod 2004; 71:691-6.