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Volumn 62, Issue 11, 2005, Pages 1186-1192

Translational research on the way to effective therapy for Alzheimer disease

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID; AMYLOID BETA PROTEIN[1-42]; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; APOLIPOPROTEIN E; ASCORBIC ACID; ATORVASTATIN; BETA SECRETASE INHIBITOR; BIOLOGICAL MARKER; CHOLINESTERASE INHIBITOR; CLIOQUINOL; DONEPEZIL; ESTROGEN; GALANTAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; INSULINASE; MEDROXYPROGESTERONE; MEMANTINE; NAPROXEN; RIVASTIGMINE; ROFECOXIB; SELEGILINE; SIMVASTATIN; TACRINE; TAU PROTEIN;

EID: 27744459938     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.62.11.1186     Document Type: Article
Times cited : (52)

References (71)
  • 1
    • 0034643888 scopus 로고    scopus 로고
    • The molecular and genetic basis of AD: The end of the beginning: The 2000 Wartenberg Lecture
    • Rosenberg RN. The molecular and genetic basis of AD: the end of the beginning: the 2000 Wartenberg Lecture. Neurology. 2000;54:2045-2054.
    • (2000) Neurology , vol.54 , pp. 2045-2054
    • Rosenberg, R.N.1
  • 2
    • 4143081404 scopus 로고    scopus 로고
    • Sensitivity and specificity of dementia coding in two Swedish disease registries
    • Jin YP, Gatz M, Johansson B, Pedersen N. Sensitivity and specificity of dementia coding in two Swedish disease registries. Neurology. 2004;63:739-741.
    • (2004) Neurology , vol.63 , pp. 739-741
    • Jin, Y.P.1    Gatz, M.2    Johansson, B.3    Pedersen, N.4
  • 4
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
    • Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet. 1992;1:345-347.
    • (1992) Nat Genet , vol.1 , pp. 345-347
    • Mullan, M.1    Crawford, F.2    Axelman, K.3    Houlden, H.4    Lilius, L.5    Winblad, B.6    Lannfelt, L.7
  • 6
    • 0002887694 scopus 로고    scopus 로고
    • Epidemiology and clinical genetics of Alzheimer disease
    • Clark CM, Trojanowski JQ, eds. New York, NY: McGraw-Hill
    • Zabar Y, Kawas C. Epidemiology and clinical genetics of Alzheimer disease. In: Clark CM, Trojanowski JQ, eds. Neurodegenerative Dementias. New York, NY: McGraw-Hill; 2000:79-94.
    • (2000) Neurodegenerative Dementias , pp. 79-94
    • Zabar, Y.1    Kawas, C.2
  • 8
    • 0023731159 scopus 로고
    • Familial Alzheimer's disease in American descendants of the Volga Germans: Probable genetic founder effect
    • Bird TD, Lampe TH, Nemens EJ, Miner GW, Sumi SM, Schellenberg GD. Familial Alzheimer's disease in American descendants of the Volga Germans: probable genetic founder effect. Ann Neurol. 1988;23:25-31.
    • (1988) Ann Neurol , vol.23 , pp. 25-31
    • Bird, T.D.1    Lampe, T.H.2    Nemens, E.J.3    Miner, G.W.4    Sumi, S.M.5    Schellenberg, G.D.6
  • 14
    • 0027354484 scopus 로고
    • Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
    • Dickson DW, Lee SC, Mattiace LA, Yen SH, Brosnan C. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia. 1993;7:75-83.
    • (1993) Glia , vol.7 , pp. 75-83
    • Dickson, D.W.1    Lee, S.C.2    Mattiace, L.A.3    Yen, S.H.4    Brosnan, C.5
  • 16
    • 0032733691 scopus 로고    scopus 로고
    • The role of oxidative stress in Alzheimer disease
    • Markesbery WR. The role of oxidative stress in Alzheimer disease. Arch Neurol. 1999;56:1449-1452.
    • (1999) Arch Neurol , vol.56 , pp. 1449-1452
    • Markesbery, W.R.1
  • 17
    • 0002157963 scopus 로고    scopus 로고
    • Molecular pathology of Alzheimer's disease: The role of amyloid
    • Growdon JH, Rossor MN, eds. London, England: Butterworth-Heinemann, Inc
    • Selkoe DJ. Molecular pathology of Alzheimer's disease: the role of amyloid. In: Growdon JH, Rossor MN, eds. Blue Books of Practical Neurology : The Dementias. London, England: Butterworth-Heinemann, Inc; 1998:257-283.
    • (1998) Blue Books of Practical Neurology: The Dementias , pp. 257-283
    • Selkoe, D.J.1
  • 18
    • 0031038918 scopus 로고    scopus 로고
    • Alzheimer's disease: Genotypes, phenotypes, and treatments
    • Selkoe DJ. Alzheimer's disease: genotypes, phenotypes, and treatments. Science. 1997;275:630-631.
    • (1997) Science , vol.275 , pp. 630-631
    • Selkoe, D.J.1
  • 19
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner GG, Wong CW. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun. 1984;122:1131-1135.
    • (1984) Biochem Biophys Res Commun , vol.122 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 20
    • 0023132387 scopus 로고
    • Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
    • Goldgaber D, Lerman MI, McBride OW, Saffriotti U, Gajdusek DC. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science. 1987;235:877-880.
    • (1987) Science , vol.235 , pp. 877-880
    • Goldgaber, D.1    Lerman, M.I.2    McBride, O.W.3    Saffriotti, U.4    Gajdusek, D.C.5
  • 23
    • 0025879957 scopus 로고
    • An in-vivo model for the neurodegenerative effects of β amyloid and protection by substance P
    • Kowal NW, Beal MF, Busciglio J, Duffy LK, Yankner BA. An in-vivo model for the neurodegenerative effects of β amyloid and protection by substance P. Proc Natl Acad Sci U S A. 1991;88:7247-7251.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 7247-7251
    • Kowal, N.W.1    Beal, M.F.2    Busciglio, J.3    Duffy, L.K.4    Yankner, B.A.5
  • 24
  • 27
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • Naslund J, Haroutunian V, Mohs R, Davis KL, Davies P, Greengard P, Buxbaum JD. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA. 2000;283:1571-1577.
    • (2000) JAMA , vol.283 , pp. 1571-1577
    • Naslund, J.1    Haroutunian, V.2    Mohs, R.3    Davis, K.L.4    Davies, P.5    Greengard, P.6    Buxbaum, J.D.7
  • 28
    • 0026776682 scopus 로고
    • Morphological differentiation and proteoglycan synthesis regulate Alzheimer amyloid precursor protein processing in PC12 and human astrocyte cultures
    • Baskin F, Rosenberg R, Davis R. Morphological differentiation and proteoglycan synthesis regulate Alzheimer amyloid precursor protein processing in PC12 and human astrocyte cultures. J Neurosci Res. 1992;32:274-279.
    • (1992) J Neurosci Res , vol.32 , pp. 274-279
    • Baskin, F.1    Rosenberg, R.2    Davis, R.3
  • 30
    • 0034762310 scopus 로고    scopus 로고
    • Genomic neurology: A new beginning
    • Rosenberg RN. Genomic neurology: a new beginning. Arch Neurol. 2001;58:1739-1741.
    • (2001) Arch Neurol , vol.58 , pp. 1739-1741
    • Rosenberg, R.N.1
  • 34
    • 0038714559 scopus 로고    scopus 로고
    • Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients
    • Baskin F, Rosenberg RN, Fang X, Hynan LS, Moore CB, Weiner M, Vega GL. Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients. Neurology. 2003;60:2006-2007.
    • (2003) Neurology , vol.60 , pp. 2006-2007
    • Baskin, F.1    Rosenberg, R.N.2    Fang, X.3    Hynan, L.S.4    Moore, C.B.5    Weiner, M.6    Vega, G.L.7
  • 37
    • 0033521498 scopus 로고    scopus 로고
    • The polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease
    • Beffert U, Arguin C, Poirier J. The polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease. Neurosci Lett. 1999;259:29-32.
    • (1999) Neurosci Lett , vol.259 , pp. 29-32
    • Beffert, U.1    Arguin, C.2    Poirier, J.3
  • 38
    • 3042857903 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Cummings JL. Alzheimer's disease. N Engl J Med. 2004;351:56-67.
    • (2004) N Engl J Med , vol.351 , pp. 56-67
    • Cummings, J.L.1
  • 43
    • 0345872128 scopus 로고    scopus 로고
    • Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial
    • Tariot PN, Farlow MR, Grossberg GT, Graham SM, McDonald S, Gergel I. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA. 2004;291:317-324.
    • (2004) JAMA , vol.291 , pp. 317-324
    • Tariot, P.N.1    Farlow, M.R.2    Grossberg, G.T.3    Graham, S.M.4    McDonald, S.5    Gergel, I.6
  • 51
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3 hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    • Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence of Alzheimer disease associated with 3 hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol. 2000;57:1439-1443.
    • (2000) Arch Neurol , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 53
    • 12144290725 scopus 로고    scopus 로고
    • Plasma levels of beta-amyloid (1-40), beta-amyloid (1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins
    • Hoglund K, Wiklund O, Vanderstichele H, Eikenberg O, Vanmechelen E, Blennow K. Plasma levels of beta-amyloid (1-40), beta-amyloid (1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins. Arch Neurol. 2004;61:333-337.
    • (2004) Arch Neurol , vol.61 , pp. 333-337
    • Hoglund, K.1    Wiklund, O.2    Vanderstichele, H.3    Eikenberg, O.4    Vanmechelen, E.5    Blennow, K.6
  • 54
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,506 high-risk individuals: A randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,506 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002;360:7-22.
    • (2002) Lancet , vol.360 , pp. 7-22
  • 56
    • 0037164315 scopus 로고    scopus 로고
    • High-risk elderly patients PROSPER from cholesterol-lowering therapy
    • Collins R, Armitage J. High-risk elderly patients PROSPER from cholesterol-lowering therapy. Lancet. 2002;360:1618-1619.
    • (2002) Lancet , vol.360 , pp. 1618-1619
    • Collins, R.1    Armitage, J.2
  • 60
    • 11444267243 scopus 로고    scopus 로고
    • Evaluation of the safety and immunogenicity of synthetic Aβ 42 (AN1792) in patients with AD
    • Bayer AJ, Bullock R, Jones RW, Wilkinson D, et al. Evaluation of the safety and immunogenicity of synthetic Aβ 42 (AN1792) in patients with AD. Neurology. 2005;64:94-101.
    • (2005) Neurology , vol.64 , pp. 94-101
    • Bayer, A.J.1    Bullock, R.2    Jones, R.W.3    Wilkinson, D.4
  • 62
    • 4143147592 scopus 로고    scopus 로고
    • Untangling Alzheimer's by paring plaques bolsters amyloid theory
    • Beckman M. Untangling Alzheimer's by paring plaques bolsters amyloid theory. Science. 2004;305:762.
    • (2004) Science , vol.305 , pp. 762
    • Beckman, M.1
  • 64
    • 11444264903 scopus 로고    scopus 로고
    • Immunization therapy for Alzheimer disease?
    • Bennett DA, Holtzman DM. Immunization therapy for Alzheimer disease? Neurology. 2005;64:10-12.
    • (2005) Neurology , vol.64 , pp. 10-12
    • Bennett, D.A.1    Holtzman, D.M.2
  • 65
    • 10044263401 scopus 로고    scopus 로고
    • Gene vaccination to bias the immune response to amyloid-β peptide as therapy for Alzheimer disease
    • Qu B, Rosenberg RN, Li L, Boyer PJ, Johnston SA. Gene vaccination to bias the immune response to amyloid-β peptide as therapy for Alzheimer disease. Arch Neurol. 2004;61:1859-1864.
    • (2004) Arch Neurol , vol.61 , pp. 1859-1864
    • Qu, B.1    Rosenberg, R.N.2    Li, L.3    Boyer, P.J.4    Johnston, S.A.5
  • 67
    • 0141851356 scopus 로고    scopus 로고
    • The application of functional genomics to Alzheimer's disease
    • Cacabelos R. The application of functional genomics to Alzheimer's disease. Pharmacogenomics. 2003;4:597-621.
    • (2003) Pharmacogenomics , vol.4 , pp. 597-621
    • Cacabelos, R.1
  • 68
    • 0035861047 scopus 로고    scopus 로고
    • Gene expression profile analysis by DNA microarrays: Promise and pitfalls
    • King HC, Sinha AA. Gene expression profile analysis by DNA microarrays: promise and pitfalls. JAMA. 2001;286:2280-2288.
    • (2001) JAMA , vol.286 , pp. 2280-2288
    • King, H.C.1    Sinha, A.A.2
  • 69
    • 0035861004 scopus 로고    scopus 로고
    • Implications of the human genome for understanding human biology and medicine
    • Subramanian G, Adams MD, Venter JC, Broder S. Implications of the human genome for understanding human biology and medicine. JAMA. 2001;286:2296-2307.
    • (2001) JAMA , vol.286 , pp. 2296-2307
    • Subramanian, G.1    Adams, M.D.2    Venter, J.C.3    Broder, S.4
  • 70
    • 0035656206 scopus 로고    scopus 로고
    • Proteomic analysis of the brain in Alzheimer's disease: Molecular phenotype of a complex disease process
    • Schonberger SJ, Edgar PF, Kydd R, Faull RL, Cooper GJ. Proteomic analysis of the brain in Alzheimer's disease: molecular phenotype of a complex disease process. Proteomics. 2001;1:1519-1528.
    • (2001) Proteomics , vol.1 , pp. 1519-1528
    • Schonberger, S.J.1    Edgar, P.F.2    Kydd, R.3    Faull, R.L.4    Cooper, G.J.5
  • 71
    • 0035860969 scopus 로고    scopus 로고
    • Clinical proteomics: Personalized molecular medicine
    • Liotta LA, Kohn EC, Petriconi EF. Clinical proteomics: personalized molecular medicine. JAMA. 2001;286:2211-2214.
    • (2001) JAMA , vol.286 , pp. 2211-2214
    • Liotta, L.A.1    Kohn, E.C.2    Petriconi, E.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.