Cloning, expression, and functional characterization of cynomolgus monkey (Macaca fascicularis) CC chemokine receptor 1

Journal of Leukocyte Biology

Volumn 78, Issue 5, 2005, Pages 1175-1184

  Gupta, Shipra ^a,b   Schulz Maronde, Sandra ^a,b   Kutzleb, Christian ^b   Richter, Rudolf ^b   Forssmann, Wolf Georg ^a   Kapp, Alexander ^a   Forssmann, Ulf ^b   Elsner, Jörn ^a,b,c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b IPF PHARMACEUTICALS GMBH   (Germany)

^c Fachklinik Bad Bentheim   (Germany)

Author keywords

Animal model; Asthma; G protein coupled receptor; Gene; Signal transduction

Indexed keywords

CALCIUM ION; CC CHEMOKINE LIGAND 14(9-74); CCL15 CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR CCR1; LIGAND; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DESENSITIZATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; ISOTOPE LABELING; MACACA; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SPLEEN; TISSUE SPECIFICITY;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CELL LINE; CHEMOKINES; CHEMOKINES, CC; CLONING, MOLECULAR; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; LIGANDS; MACACA FASCICULARIS; MICE; MOLECULAR SEQUENCE DATA; RATS; RECEPTORS, CHEMOKINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS;

ANIMALIA; MACACA; MACACA FASCICULARIS; MURINAE; PRIMATES;

EID: 27644488351     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0605326     Document Type: Article

References (39)

1. Gerard, C., Rollins, B. J. (2001) Chemokines and disease. Nat. Immunol. 2, 108-115.
2. Luster, A. D. (1998) Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338, 436-445.
3. Baggiolini, M. (1998) Chemokines and leukocyte traffic. Nature 392, 565-568.
4. Murphy, P. M. (2002) International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature. Pharmacol. Rev. 54, 227-229.
5. Neote, K., DiGregorio, D., Mak, J. Y., Horuk, R., Schall, T. J. (1993) Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 72, 415-425.
6. Gao, J. L., Kuhns, D. B., Tiffany, H. L., McDermott, D., Li, X., Francke, U., Murphy, P. H. (1993) Structure and functional expression of the human macrophage inflammatory 1α/RANTES receptor. J. Exp. Med. 177, 1421-1427.
7. Forssmann, U., Magert, H. J., Adermann, K., Escher, S. E., Forssmann, W. G. (2001) Hemofiltrate CC chemokines with unique biochemical properties: HCC-1/CCL14a and HCC-2/CCL15. J. Leukoc. Biol. 70, 357-366.
8. Gong, X., Gong, W., Kuhns, D. B., Ben Baruch, A., Howard, O. M., Wang, J. M. (1997) Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors. J. Biol. Chem. 272, 11682-11685.
9. Sarau, H. M., Rush, J. A., Foley, J. J., Brawner, M. E., Schmidt, D. B., White, J. R., Barnette, M. S. (1997) Characterization of functional chemokine receptors (CCR1 and CCR2) on EoL-3 cells: a model system to examine the role of chemokines in cell function. J. Pharmacol. Exp. Ther. 283, 411-418.
10. Youn, B. S., Zhang, S. M., Lee, E. K., Park, D. H., Broxmeyer, H. E., Murphy, P. M., Locati, M., Pease, J. E., Kim, K. K., Antol, K., Kwon, B. S. (1997) Molecular cloning of leukotactin-1: a novel human β-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immunol. 159, 5201-5205.
11. Gao, J. L., Wynn, T. A., Chang, Y., Lee, E. J., Broxmeyer, H. E., Cooper, S., Tiffany, H. L., Westphal, H., Kwon-Chung, J., Murphy, P. M. (1997) Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J. Exp. Med. 185, 1959-1968.
12. Su, S. B., Mukaida, N., Wang, J., Nomura, H., Matsushima, K. (1996) Preparation of specific polyclonal antibodies to a C-C chemokine receptor. CCR1, and determination of CCR1 expression on various types of leukocytes. J. Leukoc. Biol. 60, 658-666.
13. Broxmeyer, H. E., Cooper, S., Hangoc, G., Gao, J. L., Murphy, P. M. (1999) Dominant myelopoietic effector functions mediated by chemokine receptor CCR1. J. Exp. Med. 189, 1987-1992.
14. Phillips, R. M., Stubbs, V. E., Henson, M. R., Williams, T. J., Pease, J. E., Sabroe, I. (2003) Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter. J. Immunol. 170, 6190-6201.
15. Domachowske, J. B., Bonville, C. A., Gao, J. L., Murphy, P. M., Easton, A. J., Rosenberg, H. F. (2000) The chemokine macrophage-inflammatory protein-1 α and its receptor CCR1 control pulmonary inflammation and antiviral host defense in paramyxovirus infection. J. Immunol. 165, 2677-2682.
16. Gerard, C., Frossard, J. L., Bhatia, M., Saluja, A., Gerard, N. P., Lu, B., Steer, M. (1997) Targeted disruption of the β-chemokine receptor CCR1 protects against pancreatitis-associated lung injury. J. Clin. Invest. 100, 2022-2027.
17. Liang, M., Mallari, C., Rosser, M., Ng, H. P., May, K., Monahan, S., Bauman, J. G., Islam, I., Ghannam, A., Buckman, B., Shaw, K., Wei, G. P., Xu, W., Zhao, Z., Ho, E., Shen, J., Oanh, H., Subramanyam, B., Vergona, R., Taub, D., Dunning, L., Harvey, S., Snider, R. M., Hesselgesser, J., Morrissey, M. M., Perez, H. D. (2000) Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J. Biol. Chem. 275, 19000-19008.
18. Haringman, J. J., Kraan, M. C., Smeets, T. J., Zwinderman, K. H., Tak, P. P. (2003) Chemokine blockade and chronic inflammatory disease: proof of concept in patients with rheumatoid arthritis. Ann. Rheum. Dis. 62, 715-721.
19. Kaesler, S., Bugnon, P., Gao, J. L., Murphy, P. M., Goppelt, A., Werner, S. (2004) The chemokine receptor CCR1 is strongly up-regulated after skin injury but dispensable for wound healing. Wound Repair Regen. 12, 193-204.
20. Horuk, R., Clayberger, C., Krensky, A. M., Wang, Z., Grone, H. J., Weber, C., Weber, K. S., Nelson, P. J., May, K., Rosser, M., Dunning, L., Liang, M., Buckman, B., Ghannam, A., Ng, H. P., Islam, I., Bauman, J. G., Wei, G. P., Monahan, S., Xu, W., Snider, R. M., Morrissey, M. M., Hesselgesser, J., Perez, H. D. (2001) A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection. J. Biol. Chem. 276, 4199-4204.
21. Elsner, J., Escher, S. E., Forssmann, U. (2004) Chemokine receptor antagonists: a novel therapeutic approach in allergic diseases. Allergy 59, 1243-1258.
22. Zhang, L., Soares, M. P., Guan, Y., Matheravidathu, S., Wnek, R., Johnson, K. E., Meisher, A., Iliff, S. A., Mudgett, J. S., Springer, M. S., Daugherty, B. L. (2002) Functional expression and characterization of macaque C-C chemokine receptor 3 (CCR3) and generation of potent antagonistic anti-macaque CCR3 monoclonal antibodies. J. Biol. Chem. 277, 33799-33810.
23. Ma, B., Zhu, Z., Homer, R. J., Gerard, C., Strieter, R., Elias, J. A. (2004) The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J. Immunol. 172, 1872-1881.
24. Blease, K., Mehrad, B., Standiford, T. J., Lukacs, N. W., Kunkel, S. L., Chensue, S. W., Lu, B., Gerard, C. J., Hogaboam, C. M. (2000) Airway remodeling is absent in CCR1-/- mice during chronic fungal allergic airway disease. J. Immunol. 165, 1564-1572.
25. Gundel, R. H., Wegner, C. D., Letts, L. G. (1992) Antigen-induced acute and late-phase responses in primates. Am. Rev. Respir. Dis. 146, 369-373.
26. Van Scott, M. R., Hooker, J. L., Ehrmann, D., Shibata, Y., Kukoly, C., Salleng, K., Westergaard, G., Sandrasagra, A., Nyce, J. (2004) Dust mite-induced asthma in cynomolgus monkeys. J. Appl. Physiol. 96, 1433-1444.
27. Schelegle, E. S., Gershwin, L. J., Miller, L. A., Fanucchi, M. V., Van Winkle, L. S., Gerriets, J. P., Walby, W. F., Omlor, A. M., Buckpitt, A. R., Tarkington, B. K., Wong, V. J., Joad, J. P., Pinkerton, K. B., Wu, R., Evans, M. J., Hyde, D. M., Plopper, C. G. (2001) Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae). Am. J. Pathol. 158, 333-341.
28. Forssmann, U., Hartung, I., Balder, R., Fuchs, B., Escher, S. E., Spodsberg, N., Dulkys, Y., Walden, M., Heitland, A., Braun, A., Forssmann, W. G., Elsner, J. (2004) n-Nonanoyl-CC chemokine ligand 14, a potent CC chemokine ligand 14 analogue that prevents the recruitment of eosinophils in allergic airway-inflammation. J. Immunol. 173, 3456-3466.
29. Elsner, J., Mack, M., Bruhl, H., Dulkys, Y., Kimmig, D., Simmons, G., Clapham, P. R., Schlondorff, D., Kapp, A., Wells, T. N., Proudfoot, A. E. (2000) Differential activation of CC chemokine receptors by AOP-RANTES. J. Biol. Chem. 275, 7787-7794.
30. Sabroe, I., Peck, M. J., Van Keulen, B. J., Jorritsma, A., Simmons, G., Clapham, P. R., Williams, T. J., Pease, J. E. (2000) A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J. Biol. Chem. 275, 25985-25992.
31. Dulkys, Y., Kluthe, C., Buschermohle, T., Barg, I., Knoss, S., Kapp, A., Proudfoot, A. E., Elsner, J. (2001) IL-3 induces down-regulation of CCR3 protein and mRNA in human eosinophils. J. Immunol. 167, 3443-3453.
32. Pease, J. E., Wang, J., Ponath, P. D., Murphy, P. M. (1998) The N-terminal extracellular segments of the chemokine receptors CCR1 and CCR3 are determinants for MIP-1α and eotaxin binding, respectively, but a second domain is essential for efficient receptor activation. J. Biol. Chem. 273, 19972-19976.
33. Zoffmann, S., Chollet, A., Galzi, J. L. (2002) Identification of the extracellular loop 2 as the point of interaction between the N terminus of the chemokine MIP-1α and its CCR1 receptor. Mol. Pharmacol. 62, 729-736.
34. Detheux, M., Standker, L., Vakili, J., Munch, J., Forssmann, U., Adermann, K., Pohlmann, S., Vassart, G., Kirchhoff, F., Parmentier, M., Forssmann, W. G. (2000) Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties. J. Exp. Med. 192, 1501-1508.
35. Steinberger, P., Andris-Widhopf, J., Buhler, B., Torbett, B. E., Barbas III, C. F. (2000) Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusion. Proc. Natl. Acad. Sci. USA 97, 805-810.
36. Gauduin, M. C., Glickman, R. L., Means, R., Johnson, R. P. (1998) Inhibition of simian immunodeficiency virus (SIV) replication by CD8(+) T lymphocytes from macaques immunized with live attenuated SIV. J. Virol. 72, 6315-6324.
37. Basu, S., Schaefer, T. M., Ghosh, M., Fuller, C. L., Reinhart, T. A. (2002) Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families of chemokines. Cytokine 18, 140-148.
38. Pardigol, A., Forssmann, U., Zucht, H. D., Loetscher, P., Schulz-Knappe, P., Baggiolini, M., Forssmann, W. G., Magert, H. J. (1998) HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Natl. Acad. Sci. USA 95, 6308-6313.
39. Combadiere, C., Ahuja, S. K., Murphy, P. M. (1995) Cloning, chromosomal localization, and RNA expression of a human a β chemokine receptor-like gene. DNA Cell Biol. 14, 673-680.