QSARs for peripheral anionic site of butyrylcholinesterase with inhibitions by 4-acyloxy-biphenyl-4′-N-butylcarbamates

QSAR and Combinatorial Science

Volumn 24, Issue 8, 2005, Pages 943-952

  Lin, Gialih ^a   Chen, Gan Hong ^a   Lu, Chun Ping ^a   Yeh, Shih Chieh ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Butyrylcholinesterase; Carbamate Inhibitors; Peripheral Anionic Site; QSAR

Indexed keywords

COMPUTATIONAL CHEMISTRY; ENZYMES; MOLECULAR GRAPHICS;

BIPHENOL; BIPHENYL MOIETY; BUTYRYLCHOLINESTERASE; CARBAMATE INHIBITOR; ENZYME INHIBITORS; LEAVING GROUPS; PERIPHERAL ANIONIC SITE; QSAR; SYNTHESISED; TWO-STEP REACTIONS;

HYDROPHOBICITY;

4 ACYLOXYBIPHENYL 4' N BUTYLCARBAMATE DERIVATIVE; 4 BENZOYLOXYBIPHENYL 4' N BUTYLCARBAMATE; 4 NONANOYLOXYBIPHENYL 4' N BUTYLCARBAMATE; 4 PENTANOYLOXYBIPHENYL 4' N BUTYLCARBAMATE; 4 PHENYLACETOXYBIPHENYL 4' N BUTYLCARBAMATE; 4 TRICHLOROACETOXYBIPHENYL 4' N BUTYLCARBAMATE; 4 TRIMETHYLACETOXYBIPHENYL 4' N BUTYLCARBAMATE; 4 TRIPHENYLACETOXYBIPHENYL 4' N BUTYLCARBAMATE; 4' N BUTYLCARBAMATE DERIVATIVE; 4,4' BIPHENYL DERIVATIVE; ACETOXYBIPHENYL 4' N BUTYLCARBAMATE; ACETYLCHOLINESTERASE; ALDICARB; BIPHENYL DERIVATIVE; CARBAMATE PESTICIDE; CARBAMIC ACID DERIVATIVE; CARBARIL; CARBOFURAN; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; PHENYL GROUP; PHYSOSTIGMINE DERIVATIVE; PROPOXUR; RIVASTIGMINE; SERINE; TACRINE; TRIPHENYLACETOXY DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALZHEIMER DISEASE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHOLINESTERASE INHIBITION; CORRELATION ANALYSIS; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME SUBSTRATE; EQUILIBRIUM CONSTANT; HUMAN; HYDROPHOBICITY; MASS SPECTROMETRY; MOLECULAR INTERACTION; NONHUMAN; PARAMETER; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS; ULTRAVIOLET SPECTROSCOPY;

EID: 27644455502     PISSN: 1611020X     EISSN: None     Source Type: Journal    
DOI: 10.1002/qsar.200530124     Document Type: Article

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