Bioinspired pH-responsive polymers for the intracellular delivery of biomolecular drugs

Bioconjugate Chemistry

Volumn 14, Issue 2, 2003, Pages 412-419

  Murthy, Niren ^a   Campbell, Jean ^b   Fausto, Nelson ^b   Hoffman, Allan S ^a   Stayton, Patrick S ^a  

^a University of Washington   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONTROLLED DRUG DELIVERY; CRYPTOGRAPHY; CYTOLOGY; NUCLEIC ACIDS; PROTEINS; TARGETED DRUG DELIVERY; VIRUSES;

BIO-MOLECULAR; BIOMOLECULAR TRANSPORT; BIOTECHNOLOGY INDUSTRY; CELLULAR UPTAKE; DNA-PROTEINS; INTRACELLULAR DELIVERY; MULTI-FUNCTIONAL; PH-RESPONSIVE POLYMER; PHARMACEUTICAL INDUSTRY; POLYMERIC CARRIERS;

OLIGONUCLEOTIDES;

OLIGONUCLEOTIDE; PEPTIDE DERIVATIVE; POLYMER; VACCINE;

ARTICLE; BIOTECHNOLOGY; DRUG DELIVERY SYSTEM; DRUG INDUSTRY; ENDOSOME; MACROPHAGE; PH; SYNTHESIS;

EID: 0037345799     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc020056d     Document Type: Article

References (22)

1. Berg, K., et al. (1999) Photochemical internalization: A novel technology for delivery of macromolecules into cytosol. Cancer Res. 59, 1180.
2. Bijsterboch, M. et al. (1997) In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells. Nucleic Acids Res. 25, 3290.
3. Haensler, J., and Szoka, F. C. (1993) Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjugate Chem. 4, 312.
4. Choi, Y. H., Lui, F., Choi, J. S., Kim, S. W., and Park, J. S. (1999) Characterization of a targeted gene carrier, lactose-polyethylene glycol-grafted poly-L-lysine and its complex with plasmid DNA. Hum. Gene Ther. 10, 2657.
5. Richardson, S., Ferruti, S., and Duncan, R. (1994) Poly-(amidoamine)s as potential endosomolytic polymers: evaluation in vitro and body distribution in normal and tumour bearing animals. J. Drug Target. 6, 391.
6. Vinogradov, S. V., Bronich, T. K., and Kabanov, A. V. (1998) Self-assembly of polyamine-poly(ethylene glycol) copolymers with phosphorothioate oligonucleotides. Bioconjate Chem. 9, 805.
7. Wetering, P., et al. (1997) Structure-activity relationships of water soluble cationic methacrylate/methacrylamide polymers for nonviral gene therapy. Bioconjate Chem. 4, 687.
8. Boussif, O., Lezoualch, F., Zanta, F., Mergny, M. D., Scherman, D., Demeneix, B., and Behr, J. P. (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo. Proc. Natl. Acad. Sci. U.S.A. 92, 797.
9. Subbarao, N., Parente, R., Szoka, F., Nadasdi, L., and Pongracz, K. (1987) pH dependent bilayer destabilization by an amphiphatic peptide. Biochemistry 26, 2964.
10. Plank, C., Oberhauser, B., Mechtler, K., Koch, C., and Wagner, E. (1994) The influence of Endosome-disruptive peptides on gene transfer using synthetic virus such as gene transfer systems. J. Biol. Chem. 269, 12918.
11. Kaplan, F., and Shore, E. (1998) Encrypted morphogens of skeletogenesis: biological errors and pharmacologic potentials. Biochem. Pharmacol. 55, 373.
12. Bilecki, W., Okruszek, A., and Przewlocki, R. (1997) The Effect of Antisense Oligodeoxynucleotides on Nitric Oxide Secretion from Macrophages-Like Cells. Antisense Nucelic Acid Drug Dev. 7, 531-537.
13. Murthy, N., Robichaud, J. R., Tirrell, D. A., Stayton, P. S., and Hoffman, A. S. (1999) The design and synthesis of polymers for eukaryotic membrane disruption. J. Controlled Release 61, 137.
14. Murthy, N., Chang, I., Stayton, P. S., and Hoffman, A. S. (2001) pH-sensitive hemolysis by random copolymers of alkyl acrylates and acrylic acid. Macromol. Symp. 172, 149-155.
15. Woodle, M. C. In Poly(ethylene-glycol) Chemistry and Biological Applications (J. M. Harris and S. Zalipsky, Eds.) pp 60-77, American Chemical Society, Washington, DC.
16. Taft, R. W., and Kreevoy, M. M. (1955) The evaluation of inductive and resonance effects on reactivity. I hydrolysis rates of acetals and nonconjugated aldehydes and ketones. J. Am. Chem. Soc. 77, 5590.
17. Fife, T. H., and Jao, L. K. (1965) Substiteunt effects in acetal hydrolysis. J. Am. Chem. Soc. 30, 1492.
18. Mellman, I. (1996) Endocytosis and molecular sorting. Annu. Rev. Cell Dev. Biol. 12, 575.
19. Arima, H., et al. (1997) Specific Inhibtion of Nitric Oxide Production in Macrophages by Phosphorothioate Antisense Oligonucleotides. J. Pharm. Sci. 86, 1079-1084.
20. Ding, M., et al. (1996) Antisense Blockade of Inducable Nitric Oxide Synthase in Glial Cells Derived From Adult SJL Mice. Neuroscie. Lett. 220, 89-92.
21. Wood, L., et al. (1999) Enhancement of Methylcholanthrene-induced Neoplastic Transformation in Murine C3H 10T1/2 Fibroblasts by Antisense Phosphorothioate Oligodeoxynucleotide Sequences. Cancer Lett. 147, 163-173.
22. Ding, M., et al. (1998) Antisense Knockdown of Inducable Nitric Oxide Synthase Inhibits Induction of Experimental Autoimmune Encephalomyelitis in SJL/J Mice. J. Immun. , 2560-2564.