Poly(amidoamine)s as potential endosomolytic polymers: Evaluation in vitro and body distribution in normal and tumour-bearing animals

Journal of Drug Targeting

Volumn 6, Issue 6, 1999, Pages 391-404

  Richardson, S ^a   Ferruti, P ^b   Duncan, R ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Biocompatibility; Drug delivery; Membrane activity; Poly(amidoamine)

Indexed keywords

ETHYLAMINE; POLYAMINE; POLYLYSINE; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DISTRIBUTION; ENDOSOME; ERYTHROCYTE; HEMOLYSIS; MALE; MELANOMA; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; RADIOIODINATION; RAT; TUMOR CELL LINE;

EID: 0032847637     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869908996846     Document Type: Article

References (41)

1. Bignotti, F., Sozzani, P., Ranucci, E. and Ferruti, P. (1994) NMR-studies, molecular characterization, and degradation behavior of poly(amido amine)s. 1. Poly(amido amine) deriving from the polyaddition of 2-methylpiperazine to 1,4-bis(acryloyl)piperazine. Macromolecules, 27, 7171-7178.
2. Boussif, O., Lezoualch, F., Zanta, M.A., Mergny, M.D., Scherman, D., Demeneix, B. and Behr, J.P. (1995) A versatile vector for gene and oligonucleotide delivery into cells in culture and in vivo: Polyethylenimine. Proc. Nat. Acad. Sci. USA, 92, 7297-7310.
3. Carreno-Gomez, B. and Duncan, R. (1997) Evaluation of the biological properties of soluble chitosan and chitosan microspheres. Int. J. Pharm., 148, 231-240.
4. Duncan, R., Kopecek, J., Rejmanova, P. and Lloyd, J.B. (1982) Targeting of 2-(N-hydroxypropyl)methacrylamide copolymers to liver by incorporation of galactose residues. Biochim. Biophys. Acta, 775, 518-521.
5. Duncan, R. (1992) Drug-polymer conjugates; potential for improved chemotherapy. Anti-Cancer Drugs, 3, 175-210.
6. Duncan, R., Ferruti, P., Sgouras, D., Tuboku-Metzger, A., Ranucci, E. and Bignotti, F. (1994) A polymer-triton-X-100 conjugate capable of pH-dependant red blood cell lysis: A model system illustrating the possibility of drug delivery within acidic intracellular compartments. J. Drug Targeting, 2, 341-347.
7. Duncan, R., Dimitrijevic, S. and Evagorou, E.G. (1996) The role of polymer conjugates in the diagnosis and treatment of cancer. S.T.P. Pharma Sci., 6, 237-263.
8. Duncan, R. (1997) Polymer therapeutics for tumour-specific delivery. Chem. Indust., 7, 262-264.
9. Fattal, E., Nir, S., Parente, A. and Szoka, F. (1994) Pore-forming peptides induce rapid phospholipid flip-flop in membranes. Biochemistry, 33, 6721-6731.
10. Ferruti, P. (1985) Poly(amido-amines). Macromol. Syntheses, 9, 25.
11. Ferruti, P., Marchisio, M.A. and Barbucci, R. (1985) Synthesis, physicochemical properties and biomedical applications of poly(amidoamine)s. Polymer, 26, 1336-1348.
12. Ferruti, P., Duncan, R. and Richardson, S. (1998) Tailor-made soluble polymer carriers. In Gregoriadis, G. and McCormack, B. (Eds.) Targeting of Drugs: Stealth Therapeutic Systems (New York: Plenum Press), pp. 207-224.
13. Ferruti, P., Ranucci, E., Trotta, F., Gianasi, E., Evagorou, E., Wasil, M., Wilson, G. and Duncan, R. (1999) Synthesis, characterisation and antitumour activity of platinum (II) complexes of novel functionalised poly(amido amine)s. Makromol. Chem. Phys. (in press).
14. Graham, F.L. and Van der Eb, A.J. (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology, 52, 456-467.
15. Hoban, C.J. (1998) Recent advances in preclinical drug development in multiple sclerosis. Expert Opinion Therap. Pat., 8, 831-854.
16. Heller, J., Liu, L.S., Duncan, R. and Richardson, S. (1996) Alginate/chitosan microporous microspheres for the controlled release of proteins and antigens. Proceed. Intern. Symp. Controle. Rel. Bioact. Mater., 23, 269-270.
17. Katachalsky, A., Dannon, D., Nevo, A. and De Vries, A. (1959) Interactions of basic polyelectrolytes with red blood cells II. Agglutination of red blood cells by basic polymers. Biochim. Biophys. Acta, 33, 120-138.
18. Kichler, A., Mechtler, K., Behr, J.-P. and Wagner, E. (1997) Influence of membrane-active peptides on lipospermine/DNA complex mediated gene transfer. Bioconj. Chem., 8, 213-221.
19. Lozier, J.N., Thompson, A.R., Hu, P.C., Read, M., Brinkhous, K.M., High, K.A. and Curiel, D.T. (1994) Efficient transfection of primary cells in a canine heamophilia-B model using adenovirus polylysine DNA complexes. Human Gene Therap., 5, 313-322.
20. Maeda, H. (1994) Polymer conjugated macromolecular drugs for tumour-specific targeting. In Doumb, A.J. (Ed.) Polymeric site specific Pharmacotherapy (New York: John Wiley and Sons Ltd.), pp. 95-115.
21. McCormick, L.A., Seymour, L.C.W., Duncan, R. and Kopecek, J. (1986) Interaction of a cationic N-(2-hydroxypropyl)methacrylamide copolymer with rat liver in vivo. J. Bioact. Compat. Polymers, 1, 4-15.
22. Mellman, I. (1996) Endocytosis and molecular sorting. Ann. Rev. Cell Dev. Biol., 12, 575-625.
23. Mumper, R.J., Duguid, J.G., Anwer, K., Barron, M.K., Nitta, H. and Rolland, A.P. (1996) Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle. Pharm. Res., 13, 701-709.
24. Nevo, A., De Vries, A. and Katachalsky, A. (1955) Interaction of base polyamino acids with the red blood cell. I. Combination of polylysine with single cells. Biochim. Biophys. Acta., 17, 536-547.
25. Ranucci. E., Spagnoli, G., Ferruti, P., Sgouras, D. and Duncan, R. (1991) Polyamidoamines with potential as drug carriers: Degradation and cellular toxicity. J. Biomater. Sci., Polymer Ed., 2, 303-315.
26. Remy, J.-S., Abdallah, B., Zanta, M.A., Boussif, O., Behr, J.-P. and Demeneix, B. (1998) Gene transfer with lipospermines and polyethylenimines. Adv. Drug. Del. Rev., 30, 85-95.
27. Richardson, S., Kolbe, H. and Duncan, R. (1999a) Evaluation of highly purified chitosan fragments as a potential gene delivery vector. Int. J. Pharm. (submitted).
28. Richardson, S. (1999b) Characterisation of poly amidoamines and chitosan as potential intracytoplasmic delivery systems. Ph.D. Thesis, University of London, UK (submitted).
29. Sandhu, J.S., Keating, A., Hozumi, N. (1997) Human gene therapy. Critical Rev. Biotechnol., 17, 307-326.
30. Shaunak, S., Thornton, M., John, S., Teo, I., Peers, E., Mason, P., Krausz, T. and Davis, D.S. (1998) Reduction of the viral load of HIV-1 after the intraperitoneal administration of dextrin 2-sulphate in patients with AIDS. AIDS, 2, 399-409.
31. Sgouras, D. (1990) The evaluation of biocompatibility of soluble polymers and assessment of there potential as specific drug delivery systems. Ph.D. Thesis, University of Keele, UK.
32. Sgouras, D. and Duncan, R. (1990) Methods for the evaluation of biocompatibility of soluble synthetic polymers which have potential for biomedical use: 1 - Use of the tetrazolium-based calorimetric assay (MTT) as a preliminary screen for evaluation of in vitro cytotoxicity. J. Mater. Sci.: Mater. in Med., 1, 61-68.
33. Tang, M.X., Redemann, C.T. and Szoka, F.C. (1996) In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconj. Chem., 7, 703-714.
34. Vasey, P.A., Duncan, R., Twelves, C., Kaye, S.B., Strolin-Benedetti and Cassidy, J. (1996) Clinical and pharmacokinetic phase I study of PK1 (HPMA co-polymer doxorubicin). Proc. 9th NCI-EORTC Symposium on New Drugs in Cancer Therapy, March 12-15, Amsterdam.
35. Vasey, P.A., Kaye, S.B., Morrison, R., Twelves, C., Wilson, P., Duncan, R., Thomson, A.H., Murray, L.S., Hilditch, T.E., Murray, T., Burtles, S., Frairer, D., Figerio, E. and Cassidy, J. (1999) Phase I clinical and pharmacokinetic study of PK1 (HPMA copolymer doxorubicin): First member of a new class of chemotherapeutic agents-drug-polymer conjugates. Clin. Cancer Res., 5, 83-94.
36. Wagner, E., Plank, C., Zatloukal, K., Cotton, M. and Birnstiel, M.L. (1992a) Influenza virus hemaglutinin HA-2 H-terminal fusogenic peptides augment gene transfer by transferrin-poly-L-lysine-DNA complexes: Towards a synthetic virus-like gene-transfer vehicle. Proc. Nat. Acad. Sci. USA, 89, 7934-7938.
37. Wagner, E., Zatloukal, K., Cotton, M., Kirlappos, H., Mechtler, K., Curiel, D.T. and Birnstiel, M.L. (1992b). Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Biochemistry, 89, 6099-6103.
38. Wolfert, M.A. and Seymour, L.W. (1998) Chloroquine and amphipathic peptide helices show synergistic transfection in vitro. Gene Therapy, 5, 409-414.
39. Williams, D.F. (Ed.) (1987) Progress in Biomedical Engineering. 4. Definitions in Biomaterials. Proceed. of a Consensus Conference of the European Society for Materials, Chester, England (3-5 March) (Amsterdam: Elsevier).
40. Wu, G. and Wu, C. (1987) Receptor mediated in vivo gene transformation by a soluble DNA carrier system. J. Biol. Chem., 262, 4429-4432.
41. Zanta, M.A., Boussif, O., Adib, A. and Behr, J.-P. (1997) In vitro delivery to hepatocytes with galactosylated polythylenimine. Bioconj. Chem., 8, 839-844.