Oxidation of prostaglandin H2 and prostaglandin H2 analogues by human cytochromes P450: Analysis of ω-side chain hydroxy metabolites and four steroisomers of 5-hydroxyprostaglandin I1 by mass spectrometry

Biochemical Pharmacology

Volumn 62, Issue 4, 2001, Pages 407-415

  Oliw, Ernst H ^a   Stark, Katarina ^a   Bylund, Johan ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

5 Hydroxy PGI1; CYP2C19; CYP4A11; CYP4F8; Mass spectrometry; PGH2 analogues

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 15 HYDROXY 9ALPHA,11ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 18 HYDROXY 9,11 DIAZO 15 DEOXYPROSTAGLANDIN H2; 19 HDYROXY 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 19 HYDROXY 15 HYDROXY 9ALPHA,11 ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 19 HYDROXY 9,11 DIAZO 15 DEOXYPROSTAGLANDIN H2; 20 HYDROXY 15 HYDROXY 9ALPHA,11 ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 20 HYDROXY 9,11 DIAZO 15 DEOXYPROSTAGLANDIN H2; 5 HYDROXYPROSTAGLANDIN I 1; 6 HYDROXYHEPTANOIC ACID METHYL ESTER; 6 OXOPROSTAGLANDIN F1 ALPHA; 9,11 DIAZO 15 DEOXYPROSTAGLANDIN H2; CARBON; CYTOCHROME P450; CYTOCHROME P450 2C19; CYTOCHROME P450 4A11; CYTOCHROME P450 4F8; DRUG METABOLITE; ENDOPEROXIDE; ESTER DERIVATIVE; HEMIN; HEMOGLOBIN; LIPID PEROXIDE; OXYGEN; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN H2; RADICAL; RECOMBINANT PROTEIN; U 51065; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; DECOMPOSITION; ENZYME ACTIVITY; ENZYME METABOLISM; HEAT; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; INSECT; ISOMER; KIDNEY MICROSOME; LIPID PEROXIDATION; LIVER MICROSOME; MASS SPECTROMETRY; METABOLITE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SEMINAL PLASMA; SEMINAL VESICLE; STEREOISOMERISM;

ALKANE 1-MONOOXYGENASE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; EPOPROSTENOL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROXYLATION; KIDNEY CORTEX; LIVER; MASS SPECTROMETRY; MICROSOMES; MIXED FUNCTION OXYGENASES; MOLECULAR CONFORMATION; NADP; OXIDATION-REDUCTION; PROSTAGLANDIN ANTAGONISTS; PROSTAGLANDIN H2; PROSTAGLANDINS H; RATS;

EID: 0035882743     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00683-9     Document Type: Article

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