Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats

Hypertension

Volumn 45, Issue 1, 2005, Pages 103-108

  Zhang, Fan ^a   Deng, Huan ^a   Kemp, Rowena ^a   Singh, Harpreet ^a   Gopal, Venkat Raj ^b   Falck, John R ^b   Laniado Schwartzman, Michal ^a   Nasjletti, Alberto ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Kidney; Rats, spontaneously hypertensive; Vasoconstriction

Indexed keywords

18 HYDROXYICOSATETRAENOIC ACID; 19 HYDROXYICOSATETRAENOIC ACID; 20 HYDROXYICOSATETRAENOIC ACID; AMIDE; CYTOCHROME P450 2E1; CYTOCHROME P450 4A; CYTOCHROME P450 INHIBITOR; ICOSANOID; N METHYLSULFONYL 12,12 DIBROMODODEC 11 ENAMIDE; PHENYLEPHRINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL REACTIVITY; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; RENAL ARTERY; SENSITIZATION; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR RING;

ALKANE 1-MONOOXYGENASE; AMIDES; ANIMALS; ARACHIDONIC ACID; CYTOCHROME P-450 CYP2E1; HYDROXYEICOSATETRAENOIC ACIDS; HYPERTENSION; PHENYLEPHRINE; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RENAL ARTERY; SULFONES; TETRAETHYLAMMONIUM; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASOPRESSINS;

EID: 11244346108     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000150782.28485.91     Document Type: Article

References (25)

1. Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev. 2002;82:131-185.
2. Laethem RM, Balazy M, Falck JR, Laethem CL, Koop DR. Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1. J Biol Chem. 1993;268:12912-12918.
3. Nguyen X, Wang MH, Reddy KM, Falck JR, Schwartzman ML. Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. Am J Physiol. 1999;276:R1691-R1700.
4. Imig JD, Zou AP, Stec DE, Harder DR, Falck JR, Roman RJ. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. Am J Physiol 1996;270:R217-R227.
5. Wang MH, Guan H, Nguyen X, Zand BA, Nasjletti A, Laniado-Schwartzman M. Contribution of cytochrome P-450 4A1 and 4A2 to vascular 20- hydroxyeicosatetraenoic acid synthesis in rat kidneys. Am J Physiol. 1999;276:F246-F253.
6. Kaide J, Wang MH, Wang JS, Zhang F, Gopal VR, Falck JR, Nasjletti A, Laniado-Schwartzman M. Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries. Am J Physiol Renal Physiol. 2003;284:F51-F56.
7. Imig JD, Pham BT, LeBlanc EA, Reddy KM, Falck JR, Inscho EW. Cytochrome P450 and cyclooxygenase metabolites contribute to the endothelin-1 afferent arteriolar vasoconstrictor and calcium responses. Hypertension. 2000;35:307-312.
8. Imig JD, Falck JR, Inscho EW. Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness. Br J Pharmacol. 1999;127:1399-1405.
9. Zou AP, Imig JD, Ortiz de Montellano PR, Sui Z, Falck JR, Roman RJ. Effect of P-450 omega-hydroxylase metabolites of arachidonic acid on tubuloglomerular feedback. Am J Physiol. 1994;266:F934-F941.
10. Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ. 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. Am J Physiol. 1996;270:R228-R237.
11. Kaide J-I, Zhang F, Wei Y, Wang W, Gopal V, Falck J, Laniado-Schwartzman M, Nasjletti A. Vascular CO counterbalances the sensitizing influence of 20-HETE on agonist-induced vasoconstriction. Hypertension. 2004;44:210-216.
12. 2+ current. J Physiol 1998;507:771-781.
13. Randriamboavonjy V, Busse R, Fleming I. 20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase. Hypertension. 2003;41:801-806.
14. Alonso-Galicia M, Falck JR, Reddy KM, Roman RJ. 20-HETE agonists and antagonists in the renal circulation. Am J Physiol. 1999;277: F790-F796.
15. Carroll MA, Balazy M, Margiotta P, Huang DD, Falck JR, McGiff JC. Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996;271:R863-R869.
16. Zhang F, Wang MH, Krishna UM, Falck JR, Laniado-Schwartzman M, Nasjletti A. Modulation by 20-HETE of phenylephrine-induced mesenteric artery contraction in spontaneously hypertensive and Wistar-Kyoto rats. Hypertension. 2001;38:1311-1315.
17. Touyz RM, Deng LY, Li JS, Schiffrin EL. Differential effects of vasopressin and endothelin-1 on vascular contractile and calcium responses in pressurized small arteries from spontaneously hypertensive rats. J Hypertens. 1996;14:983-991.
18. Chu ZM, Croft KD, Kingsbury DA, Falck JR, Reddy KM, Beilin LJ. Cytochrome P450 metabolites of arachidonic acid may be important mediators in angiotensin II-induced vasoconstriction in the rat mesentery in vivo. Clin Sci (Lond). 2000;98:277-282.
19. Falck JR, Belosludtsev Y, Kishta-Reddy KM-RK, Fiona-Shortt M, Chauhan K, Capdevila JH, Wei W. Eicosanoid biosynthesis: differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase. Bioorg Med Chem. 1997;7:3053-3056.
20. Brady JF, Xiao F, Wang MH, Li Y, Ning SM, Gapac JM, Yang CS. Effects of disulfiram on hepatic P450IIE1, other microsomal enzymes, and hepatotoxicity in rats. Toxicol Appl Pharmacol. 1991;108:366-373.
21. Andresen JJ, Faraci FM, Heistad DD. Vasomotor responses in MnSOD-deficient mice. Am J Physiol Heart Circ Physiol. 2004;287: H1141-H1148.
22. Croft KD, McGiff JC, Sanchez-Mendoza A, Carroll MA. Angiotensin II releases 20-HETE from rat renal microvessels. Am J Physiol Renal Physiol. 2000;279:F544-F551.
23. Liu Y, Hudetz AG, Knaus HG, Rusch NJ. Increased expression of Ca2+-sensitive K+ channels in the cerebral microcirculation of genetically hypertensive rats: evidence for their protection against cerebral vasospasm. Circ Res. 1998;82:729-737.
24. Imig JD, Falck JR, Gebremedhin D, Harder DR, Roman RJ. Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450. Hypertension. 1993;22:357-364.
25. Xu F, Straub WO, Pak W, Su P, Maier KG, Yu M, Roman RJ, Ortiz de Montellano PR, Kroetz DL. Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid omega-hydroxylase activity. Am J Physiol Regul Integr Comp Physiol. 2002;283:R710-R720.