The CTLA-4 gene is expressed in placental fibroblasts

Molecular Human Reproduction

Volumn 5, Issue 1, 1999, Pages 84-87

  Kaufman, K A ^a   Bowen, J A ^b   Tsai, A F ^a   Bluestone, J A ^a   Hunt, J S ^b   Ober, C ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

CTLA 4; Fibroblasts; Immunochemistry; Maternal fetal interface; Peripheral self tolerance

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ARTICLE; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; NORMAL HUMAN; PLACENTA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; FEMALE; FIBROBLASTS; GESTATIONAL AGE; HUMANS; IMMUNOCONJUGATES; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOHISTOCHEMISTRY; MATERNAL-FETAL EXCHANGE; MESODERM; PLACENTA; PREGNANCY; RNA, MESSENGER; TROPHOBLASTS;

EID: 0032925437     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/5.1.84     Document Type: Article

References (21)

1. Adinolfi, M. (1989) New and old aspects of the ontogeny of immune responses. In Stern, C.M.M. (ed.), Immunology of Pregnancy and its Disorders. Kluwer Academic Publishers, Boston, USA, pp. 33-59.
2. Bianchi, D.W., Zickwolf, G.K., Weil, G.J. et al. (1996) Male fetal progenitor cells persist in maternal blood for as long as 27 years. Proc. Natl. Acad. Sci. USA., 93, 705-708.
3. Bonney, E.A. and Matzinger, P. (1997) The maternal immune system's interaction with circulating fetal cells. J. Immunol., 158, 40-47.
4. Dariavich, P., Mattéi, M.-G., Golstein, P. et al. (1988) Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur. J. Immunol., 18, 1901-1905.
5. Donner, H., Rau, H., Walfish, P.G. et al. (1997) CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. J. Clin. Endocrinol., 82, 143-146.
6. Fant, M.E. (1991) In vitro growth rate of placental fibroblasts is developmentally regulated. J. Clin. Invest., 88, 1697.
7. Hunt, J.S. (1994) Immunologically relevant cells in the uterus. Biol. Reprod., 50, 461-466.
8. June, C.H., Vandenberghe, P. and Thompson, C. (1994) The CD28 and CTLA-4 receptor family. In Samelson, L.E. (ed.), Lymphocyte Activation. Karger, Basel, Switzerland, pp. 62-90.
9. Kabawat, S.E., Mostoufi-Zadeh, M., Driscoll, S.G. et al. (1985) Implantation site in normal pregnancy: A study with monoclonal antibodies. Am. J. Pathol., 118, 76-84.
10. Li, Y., Matsuzaki, N., Masuhiro, K. et al. (1992) Trophoblast-derived tumor necrosis factor-alpha induces release of human chorionic gonadotropin using interleukin-6 (IL-6) and IL-6-receptor-dependent system in the normal human trophoblasts. J. Clin. Endocrinol. Metab., 74, 184-191.
11. Marron, M.P., Raffel, L.J., Garchon, H.-J. et al. (1997) Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA-4 polymorphisms in multiple ethnic groups. Hum. Mol. Genet., 6, 1275-1282.
12. Medawar, P.B. (1953) Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp. Soc. Exp. Biol., 7, 320-338.
13. Neki, R., Matsuzaki, N., Yamanaka, K. et al. (1993) The interleukin-6 (IL-6)/IL-6 receptor system induces human chorionic gonadotropin production by activating tyrosine kinase-dependent signal transduction pathway different from pathways triggered by protein kinase activators including gonadotropin releasing hormone. J. Clin. Endocrinol. Metab., 77, 704-709.
14. Nistocò, L., Buzzetti, R., Pritchard, L.E. et al. (1996) The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Hum. Mol. Genet., 5, 1075-1080.
15. Pedersen, A.M., Fulton, S.K., Porter, L. et al. (1995) Tumor necrosis factor-alpha affects in vitro hormone production by JEG-3 choriocarcinoma cell cultures. J. Reprod. Immunol., 29, 69-80.
16. Piotrowski, P. and Croy, B.A. (1996) Maternal cells are widely distributed in murine fetuses in utero. Biol. Reprod., 54, 1103-1110.
17. Socie, G., Gluckman, E., Carosella, E. et al. (1994) Search for maternal cells in human umbilical cord blood by polymerase chain reaction amplification of two minisatellite sequences. Blood, 83, 340-344.
18. Tivol, E.A., Borriello, F., Schweitzer, A.N. et al. (1995) Loss of CTLA-4 leads to massive lymphproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity, 3, 541-547.
19. Tsai, A.F., Kaufman, K.A., Walker, M.A. et al. (1998) Transmission disequilibrium of maternal CTLA4 microsatellite alleles in idiopathic recurrent miscarriage (RSA). J. Reprod. Immunol., 40, 149-159.
20. Waterhouse, P., Penninger, J.M., Timms, E. et al. (1995) Lymphoproliferative disorders with early lethality in mice deficient for Ctla-4. Science, 270, 985-988.
21. Yanagawa, T., Hidaka, Y., Guimaraes, V. et al. (1995) CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population. J. Clin. Endocrinol., 80, 41-45.