A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells

European Journal of Immunology

Volumn 29, Issue 11, 1999, Pages 3596-3602

  Magistrelli, Giovanni ^a   Jeannin, Pascale ^a   Herbault, Nathalie ^a   De Coignac, Amélie Benoit ^a   Gauchat, Jean François ^a   Bonnefoy, Jean Yves ^a   Delneste, Yves ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Alternative splicing; CTLA 4; Human T lymphocyte

Indexed keywords

CD28 ANTIGEN; COMPLEMENTARY DNA; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IONOMYCIN; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD3; PHORBOL 13 ACETATE 12 MYRISTATE;

ALTERNATIVE RNA SPLICING; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; FRAMESHIFT MUTATION; HUMAN; HUMAN CELL; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0032728162     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199911)29:11<3596::AID-IMMU3596>3.0.CO;2-Y     Document Type: Article

References (41)

1. Schwartz, R. H., A cell culture model for T lymphocyte clonal anergy. Science 1990. 248: 1349-1356.
2. Chambers, C. A. and Allison, J. P., Co-stimulation in T cell responses. Curr. Opin. Immunol. 1997. 9: 396-404.
3. Gimmi, C. D., Freeman, G. J., Gribben, J. G., Sugita, K., Freedman, A. S., Morimoto, C. and Nadler, L. M., B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc. Natl. Acad. Sci. USA 1991. 88: 6575-6579.
4. Linsley, P. S., Brady, W., Grosmaire, L., Aruffo, A., Damle, N. K. and Ledbetter, J. A., Binding of the B cell activation antigen B7 to CD28 costimulated T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 1991. 173: 721-730.
5. Linsley, P. S. and Ledbetter, J. A., The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 1993. 11: 191-212.
6. Kohno, K., Shibata, Y., Matsuo, Y. and Minowada, J., CD28 molecule as a receptor-like function for accessory signals in cell-mediated augmentation of IL-2 production. Cell. Immunol. 1990. 131: 1-10.
7. Damle, N. K., Linsley, P. S. and Ledbetter, J. A., Direct helper T cell-induced B cell differentiation involves interaction between T cell antigen CD28 and B cell activation antigen B7. Eur. J. Immunol. 1991. 21: 1277-1282.
8. Azuma, M., Cayabyab, M., Buck, D., Phillips, J. H. and Lanier, L. L., CD28 interaction with B7 costimulated primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J. Exp. Med. 1992. 175: 353-360.
9. Harding, F. A. and Allison, J. P., CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help. J. Exp. Med. 1993. 177: 1791-1796.
10. Harper, K., Balzano, C., Rouvier, E., Mattel, M. G., Luciani, M. F. and Golstein, P., CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. J. Immunol. 1991. 147: 1037-1044.
11. Linsley, P. S., Brady, W., Urnes, M., Grosmaire, L. S., Damle, N. K. and Ledbetter, J. A., CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 1991. 174: 561-569.
12. June, C. H., Bluestone, J. A., Nadler, L. M. and Thompson, C. B., The B7 and CD28 receptor families. Immunol. Today 1994. 15: 321-331.
13. Peach, R. J., Bajorath, J., Brady, W., Leytze, G., Green, J., Naemura, J. and Linsley, P. S., Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1. J. Exp. Med. 1994. 180: 2049-2058.
14. Kariv, I., Truneh, A. and Sweet, R. W., Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function. J. Immunol. 1996. 157: 29-38.
15. van der Merwe, P. A., Bodian, D. L., Daenke, S., Linsley, P. and Davis, S. J., CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J. Exp. Med. 1997. 185: 393-403.
16. Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., Thompson, C. B. and Bluestone, J. A., CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994. 1: 405-413.
17. Krummel, M. F. and Allison, J. P., CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 1995. 182: 459-465.
18. Saito, T., Negative regulation of T cell activation. Curr. Opin. Immunol. 1998. 10: 313-321.
19. Waterhouse, P., Penninger, J. M., Timms, E., Wakeham, A., Shahinian, A., Lee, K. P., Thompson, C. B., Griesser, H. and Mak, T., Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995. 270: 985-988.
20. Tivol, E. A., Borriello, F., Schweitzer, A. N., Lynch, W. P., Bluestone, J. A. and Sharpe, A. H., Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995. 3: 541-547.
21. Kearney, E. R., Walunas, T. L., Karr, R. W., Morton, P. A., Loh, D. Y., Bluestone, J. A. and Jenkins, M. K., Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 1995. 155: 1032-1036.
22. Leach, D. R., Krummel, M. F. and Allison, J. P., Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996 271: 1734-1736.
23. Brunet, J. F., Denizot, F., Luciani, M. F., Roux-Dosseto, M., Suzan, M., Mattei, M. G. and Golstein, P., A new member of the immunoglobulin superfamily-CTLA-4. Nature 1987. 328: 267-269.
24. Dariavach, P., Mattei, M. G., Golstein, P. and Lefranc, M. P., Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur. J. Immunol. 1988. 18: 1901-1905.
25. Freeman, G. J., Lombard, D. B., Gimmi, C. D, Brod, S. A., Lee, K., Laning, J. C., Hafler, D. A., Dorf, M. E., Gray, G. S., Reiser, H., June, C. H., Thompson C. B. and Nadler, L. M., CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. J. Immunol. 1992. 149: 3795-3801.
26. Perkins, D., Wang, Z., Donovan, C. et al., Regulation of CTLA-4 expression during T cell activation. J. Immunol. 1996. 156: 4154-4159.
27. Finn, P. W., He, H., Wang, Y., Wang, Z., Guan, G., Listman, J. and Perkins, D. L., Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic and stability. J. Immunol. 1997. 158: 4074-4081.
28. Linsley, P. S., Nadler, S. G., Bajorath, J., Peach, R., Leung, H. T., Rogers, J., Bradshaw, J., Stebbins, M., Leytze, G., Brady, W., Malacko, A. R., Marquardt, H. and Haw, S. Y., Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 molecules. J. Biol. Chem. 1995. 270: 15417-15424.
29. Lindsten, T., Lee, K. P., Harris, E. S., Petryniak, B., Craighead, N., Reynolds, P. J., Lombard, D. B., Freeman, G. J., Nadler, L. M., Gray, G. S., Thompson, C. B. and June, C. H., Characterization of CTLA-4 structure and expression on human T cells. J. Immunol. 1993. 151: 3489-3499.
30. Mount, S., A catalogue of splice junction sequences. Nucleic Acids Res. 1982. 10: 459-472.
31. Shiratori, T., Miyatake, S., Ohno, H., Nakaseko, C., Isono, K., Bonifacino, J. S. and Saito, T., Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 1997. 6: 583-589.
32. Chuang, E., Alegre, M. L., Duckett, C. S., Noel, P. J., Vander Heiden, M. G. and Thompson, C. B., Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J. Immunol. 1997. 159: 144-151.
33. Greene, J. L., Leytze, G. M., Emswiler, J., Peach, R., Bajorath, J., Cosand, W. and Linsley, P. S., Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions. J. Biol. Chem. 1996. 271: 26762-26771.
34. Linsley, P. S., Wallace, P. M., Johnson, J., Gibson, M. G., Greene, J. L., Ledbetter, J. A., Singh, C. and Tepper, M., Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 1992. 257: 792-795.
35. Shahinian, A., Pfeffer, K., Lee, K. P., Kundig, T. M., Kishihara, K., Wakeham, A., Kawai, K., Ohashi, P. S., Thompson, C. B. and Mak, T. W., Differential T cell costimulatory requirements in CD28-deficient mice. Science 1993. 261: 609-612.
36. Ronchese, F., Hausmann, B., Hubele, S. and Lane, P., Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo. J. Exp. Med. 1994. 179: 809-817.
37. Finck, B. K., Linsley, P. S. and Wofsy, D., Treatment of murine lupus with CTLA4lg. Science 1994. 265: 1225-1227.
38. Cross, A. H., Girard, T. J., Giacoletto, K. S., Evans, R. J., Keeling, R. M., Lin, R. F., Trotter, J. L. and Karr, R., Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation. J. Clin. Invest. 1995. 95: 2783-2789.
39. Maiuri, L., Auricchio, S., Coletta, S., De Marco, G., Picarelli, A., Di Tola, M., Quaratino, S. and Londei, M., Blockade of T-cell costimulation inhibits T-cell action in celiac disease. Gastroenterology 1998. 115: 564-572.
40. Webb, L. M., Walmsley, M. J. and Feldmann, M., Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2. Eur. J. Immunol. 1996. 26: 2320-2328.
41. Hurwitz, A. A., Sullivan, T. J., Krummel, M. F., Sobel, R. A. and Allison, J., Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis. J. Neuroimmunol. 1997. 73: 57-62.