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Volumn 2, Issue 3, 2005, Pages 226-231

Peroxisome proliferator-activated receptor-γ as a regulator of lung inflammation and repair

Author keywords

ARDS; Gene regulation; Transcriptional factors

Indexed keywords

CELL NUCLEUS RECEPTOR; HORMONE RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN;

EID: 27144456205     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200501-010AC     Document Type: Conference Paper
Times cited : (119)

References (62)
  • 1
    • 0034604129 scopus 로고    scopus 로고
    • The acute respiratory distress syndrome
    • Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342:1334-1349.
    • (2000) N Engl J Med , vol.342 , pp. 1334-1349
    • Ware, L.B.1    Ma, M.2
  • 2
    • 0032911805 scopus 로고    scopus 로고
    • The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome
    • Pugin J, Verghese G, Widmer MC, Matthay MA. The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Crit Care Med 1999;27: 304-312.
    • (1999) Crit Care Med , vol.27 , pp. 304-312
    • Pugin, J.1    Verghese, G.2    Widmer, M.C.3    Matthay, M.A.4
  • 4
    • 0013854955 scopus 로고
    • Nature of hepatomegalic effect produced by ethyl-chlorophenoxy- isobutyrate in the rat
    • Hess R, Staubli W, Riess W. Nature of hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat. Nature 1965;208:856-888.
    • (1965) Nature , vol.208 , pp. 856-888
    • Hess, R.1    Staubli, W.2    Riess, W.3
  • 5
    • 0033542873 scopus 로고    scopus 로고
    • Medical significance of peroxisome proliferator-activated receptors
    • Vamecq J, Latruffe N. Medical significance of peroxisome proliferator-activated receptors. Lancet 1999;354:141-148.
    • (1999) Lancet , vol.354 , pp. 141-148
    • Vamecq, J.1    Latruffe, N.2
  • 6
    • 0034034671 scopus 로고    scopus 로고
    • Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators
    • Corton JC, Anderson SP, Stauber A. Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Annu Rev Pharmacol Toxicol 2000;40:491-518.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 491-518
    • Corton, J.C.1    Anderson, S.P.2    Stauber, A.3
  • 7
    • 0033018148 scopus 로고    scopus 로고
    • Identification of nuclear receptor co repressor as a peroxisome proliferators-activated receptor-α interacting protein
    • Dowell P. Identification of nuclear receptor co repressor as a peroxisome proliferators-activated receptor-α interacting protein. J Biol Chem 1999; 274:15901-15907.
    • (1999) J Biol Chem , vol.274 , pp. 15901-15907
    • Dowell, P.1
  • 8
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994;79:1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 9
    • 0036779687 scopus 로고    scopus 로고
    • Emerging roles of PPARs in inflammation and immunity
    • Dayes RA, Jones DC. Emerging roles of PPARs in inflammation and immunity. Nat Revs/Immunol 2002;2:748-759.
    • (2002) Nat Revs/Immunol , vol.2 , pp. 748-759
    • Dayes, R.A.1    Jones, D.C.2
  • 10
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998;391:82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 11
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998;91:79-82.
    • (1998) Nature , vol.91 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 12
    • 0034057069 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in the cardiovascular system
    • Bishop-Bailey D. Peroxisome proliferator-activated receptors in the cardiovascular system. Br J Pharmacol 2000;129:S23-S34.
    • (2000) Br J Pharmacol , vol.129
    • Bishop-Bailey, D.1
  • 15
    • 0028972026 scopus 로고
    • A prostaglandin metabolite binds peroxisome proliferator-activated receptor y promotes adipocyte differentiation
    • Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. A prostaglandin metabolite binds peroxisome proliferator-activated receptor y promotes adipocyte differentiation. Cell 1995;83:813-819.
    • (1995) Cell , vol.83 , pp. 813-819
    • Kliewer, S.A.1    Lenhard, J.M.2    Willson, T.M.3    Patel, I.4    Morris, D.C.5    Lehmann, J.M.6
  • 17
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression gene expression through ligand activation of PPAR-γ
    • Nagy L, Tontonoz P, Alvarez JGA, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression gene expression through ligand activation of PPAR-γ. Cell 1998;93:229-240.
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.A.3    Chen, H.4    Evans, R.M.5
  • 18
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 1995;270:12953-12956.
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 19
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1997;272:3406-3410.
    • (1997) J Biol Chem , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 20
    • 0034693323 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-γ and nuclear factor κB
    • Chung SL, Kand BK, Kim SH, Pak YK, Cho D, Trinchieri G, Kim TS. Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-γ and nuclear factor κB. J Biol Chem 2000;275:32681-32687.
    • (2000) J Biol Chem , vol.275 , pp. 32681-32687
    • Chung, S.L.1    Kand, B.K.2    Kim, S.H.3    Pak, Y.K.4    Cho, D.5    Trinchieri, G.6    Kim, T.S.7
  • 21
    • 0031870652 scopus 로고    scopus 로고
    • Macrophages in human atheroma contain PPARgamma: Differentiation- dependent peroxisomal proliferator-activated receptor gamma (PPARgamma) expression and reduction of MMP-9 activity through PPAR gamma activation in mononuclear phagocytes in vitro
    • Marx N, Sukhova G, Murphy C, Libby P, Plutzky J. Macrophages in human atheroma contain PPARgamma: differentiation- dependent peroxisomal proliferator-activated receptor gamma (PPARgamma) expression and reduction of MMP-9 activity through PPAR gamma activation in mononuclear phagocytes in vitro. Am J Pathol 1998; 153:17-23.
    • (1998) Am J Pathol , vol.153 , pp. 17-23
    • Marx, N.1    Sukhova, G.2    Murphy, C.3    Libby, P.4    Plutzky, J.5
  • 22
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1
    • Delerive P, DeBosscher K, Besnard S, Vanden Berghe W, Peters JM, Gonzalez FJ, Fruchart JC, Tedgui A, Haegeman G, Staels B. Peroxisome proliferator-activated receptor-α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1. J Biol Chem 1999;274:32048-32054.
    • (1999) J Biol Chem , vol.274 , pp. 32048-32054
    • Delerive, P.1    DeBosscher, K.2    Besnard, S.3    Vanden Berghe, W.4    Peters, J.M.5    Gonzalez, F.J.6    Fruchart, J.C.7    Tedgui, A.8    Haegeman, G.9    Staels, B.10
  • 23
    • 0033520304 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator proten-1 signaling pathway
    • Delerive P, Martin-Nizard F, Chinetti G, Trottein F, Fruchart JC, Najib J, Duriez P, Staels B. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator proten-1 signaling pathway. Circ Res 1999;85:394-402.
    • (1999) Circ Res , vol.85 , pp. 394-402
    • Delerive, P.1    Martin-Nizard, F.2    Chinetti, G.3    Trottein, F.4    Fruchart, J.C.5    Najib, J.6    Duriez, P.7    Staels, B.8
  • 24
    • 0034711185 scopus 로고    scopus 로고
    • Induction of 1κBα expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-α activators
    • Delerive P, Gervois P, Fruchart JC, Staels B. Induction of 1κBα expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-α activators. J Biol Chem 2000;275:36703-36707.
    • (2000) J Biol Chem , vol.275 , pp. 36703-36707
    • Delerive, P.1    Gervois, P.2    Fruchart, J.C.3    Staels, B.4
  • 27
    • 15744396059 scopus 로고    scopus 로고
    • PPAR-7 activation inhibits angiogenesis by blocking ELR+ CXC chemokine production in non small cell lung cancer
    • Keshamouni VG, Arenberg DA, Reddy RC, Newstead MJ, Anthwal S, Standiford TJ. PPAR-7 activation inhibits angiogenesis by blocking ELR+ CXC chemokine production in non small cell lung cancer. Neoplasia 2005;7:294-301.
    • (2005) Neoplasia , vol.7 , pp. 294-301
    • Keshamouni, V.G.1    Arenberg, D.A.2    Reddy, R.C.3    Newstead, M.J.4    Anthwal, S.5    Standiford, T.J.6
  • 29
    • 2142787409 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma (PPAR-gamma) activation in naive mouse T cells induces cell death
    • Harris SG, Phipps RP. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) activation in naive mouse T cells induces cell death. Ann N Y Acad Sci 2000;905:297-300.
    • (2000) Ann N Y Acad Sci , vol.905 , pp. 297-300
    • Harris, S.G.1    Phipps, R.P.2
  • 31
    • 0035132330 scopus 로고    scopus 로고
    • PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
    • Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM, PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med 2001;7:48-52.
    • (2001) Nat Med , vol.7 , pp. 48-52
    • Chawla, A.1    Barak, Y.2    Nagy, L.3    Liao, D.4    Tontonoz, P.5    Evans, R.M.6
  • 32
    • 0034114625 scopus 로고    scopus 로고
    • Differential activation of peroxisome proliferator-activated receptor-γ by troglitazone and rosiglitazone
    • Camp HS, Li O, Wise SC, Hong YH, Frankowski CL, Shen XQ, Vanbogelen R, Leff T. Differential activation of peroxisome proliferator-activated receptor-γ by troglitazone and rosiglitazone. Diabetes 2000; 49:539-547.
    • (2000) Diabetes , vol.49 , pp. 539-547
    • Camp, H.S.1    Li, O.2    Wise, S.C.3    Hong, Y.H.4    Frankowski, C.L.5    Shen, X.Q.6    Vanbogelen, R.7    Leff, T.8
  • 39
    • 1642493927 scopus 로고    scopus 로고
    • Antiinflammatory roles of peroxisome proliterator-activated receptor γ in human alveolar macrophages
    • Asada K, Sasaki S, Suda T, Chica K, Nakamura H. Antiinflammatory roles of peroxisome proliterator-activated receptor γ in human alveolar macrophages. Am J Respir Crit Care Med 2004;169:195-200.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 195-200
    • Asada, K.1    Sasaki, S.2    Suda, T.3    Chica, K.4    Nakamura, H.5
  • 40
    • 0032747491 scopus 로고    scopus 로고
    • Animal model: Induction of lung fibrosis in the mouse by intratracheal instillation of fluorescein isothiocyanate is not T-cell dependent
    • Christensen PJ, Goodman RE, Pastoriza L, Moore B, Toews GB. Animal model: induction of lung fibrosis in the mouse by intratracheal instillation of fluorescein isothiocyanate is not T-cell dependent. Am J Pathol 1999;155:1773-1779.
    • (1999) Am J Pathol , vol.155 , pp. 1773-1779
    • Christensen, P.J.1    Goodman, R.E.2    Pastoriza, L.3    Moore, B.4    Toews, G.B.5
  • 43
    • 2642527708 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma regulates eosinophil functions: A new therapeutic target for allergic airway inflammation
    • Ueki S, Matsuwaki Y, Kayaba H, Oyamada H, Kanda A, Usami A, Saito N, Chihara J. Peroxisome proliferator-activated receptor gamma regulates eosinophil functions: a new therapeutic target for allergic airway inflammation. Int Arch Allergy Immunol 2004;134:30-36.
    • (2004) Int Arch Allergy Immunol , vol.134 , pp. 30-36
    • Ueki, S.1    Matsuwaki, Y.2    Kayaba, H.3    Oyamada, H.4    Kanda, A.5    Usami, A.6    Saito, N.7    Chihara, J.8
  • 44
    • 0021071294 scopus 로고
    • Response of the lower respiratory tract to injury. Mechanisms of repair of the parenchymal cells of the alveolar wall
    • Rennard SI, Bitterman PB, Crystal RG. Response of the lower respiratory tract to injury. Mechanisms of repair of the parenchymal cells of the alveolar wall. Chest 1983;84:735-739.
    • (1983) Chest , vol.84 , pp. 735-739
    • Rennard, S.I.1    Bitterman, P.B.2    Crystal, R.G.3
  • 45
    • 0034973231 scopus 로고    scopus 로고
    • Peroxisome proliferators-activated receptor-gamma regulates airway epithelial cell activation
    • Wang AC, Dai X, Luu B, Conrad DJ. Peroxisome proliferators-activated receptor-gamma regulates airway epithelial cell activation. Am J Respir Cell Mol Biol 2001;24:688-693.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 688-693
    • Wang, A.C.1    Dai, X.2    Luu, B.3    Conrad, D.J.4
  • 47
    • 0028278029 scopus 로고
    • Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis
    • Zhang K, Rekhter MD, Gordon D, Phan SH. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. Am J Pathol 1994;145:114-120.
    • (1994) Am J Pathol , vol.145 , pp. 114-120
    • Zhang, K.1    Rekhter, M.D.2    Gordon, D.3    Phan, S.H.4
  • 48
    • 0037016773 scopus 로고    scopus 로고
    • Ligands of perioxisome proliferator-activated receptor-γ block activation of pancreatic stellate cells
    • Masamune A, Kikuta K, Satoh M, Sakai Y, Satoh A, Shimosegawa T. Ligands of perioxisome proliferator-activated receptor-γ block activation of pancreatic stellate cells. J Biol Chem 2002;277:141-147.
    • (2002) J Biol Chem , vol.277 , pp. 141-147
    • Masamune, A.1    Kikuta, K.2    Satoh, M.3    Sakai, Y.4    Satoh, A.5    Shimosegawa, T.6
  • 51
    • 18844458812 scopus 로고    scopus 로고
    • PPAR gamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production; implications for therapy of lung fibrosis
    • Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Redonnet M, Phipps RP, Sime PJ. PPAR gamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production; implications for therapy of lung fibrosis. Am J Physiol Lung Cell Mol Physiol 2005;288:1146-1153.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288 , pp. 1146-1153
    • Burgess, H.A.1    Daugherty, L.E.2    Thatcher, T.H.3    Lakatos, H.F.4    Redonnet, M.5    Phipps, R.P.6    Sime, P.J.7
  • 53
    • 1642401329 scopus 로고    scopus 로고
    • Protective effects of pre-ischemic treatment with pioglizatone, a peroxisome proliferator-activated receptor-γ ligand, on lung ischemia-reperfusion injury in rats
    • Ito K, Shimada J, Kato D, Toda S, Takagi T, Naito Y, Yoshikawa T, Kitamura N. Protective effects of pre-ischemic treatment with pioglizatone, a peroxisome proliferator-activated receptor-γ ligand, on lung ischemia-reperfusion injury in rats. Eur J Cardiothorac Surg 2004; 25:530-536.
    • (2004) Eur J Cardiothorac Surg , vol.25 , pp. 530-536
    • Ito, K.1    Shimada, J.2    Kato, D.3    Toda, S.4    Takagi, T.5    Naito, Y.6    Yoshikawa, T.7    Kitamura, N.8
  • 54
    • 0036901274 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ (PPAR-γ) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets
    • Okada M, Yan SF, Pinsky DJ. Peroxisome proliferator-activated receptor-γ (PPAR-γ) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets. FASEB J 2002;16:1861-1868.
    • (2002) FASEB J , vol.16 , pp. 1861-1868
    • Okada, M.1    Yan, S.F.2    Pinsky, D.J.3
  • 55
    • 0042624848 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors α and γ down-regulate allergic inflammation and eosinophil activation
    • Woerly G, Honda K, Loyens M, Papin J-P, Auwerx J, Staels B, Capron M, Dombrowicz D. Peroxisome proliferator-activated receptors α and γ down-regulate allergic inflammation and eosinophil activation. J Exp Med 2003;198:411-421.
    • (2003) J Exp Med , vol.198 , pp. 411-421
    • Woerly, G.1    Honda, K.2    Loyens, M.3    Papin, J.-P.4    Auwerx, J.5    Staels, B.6    Capron, M.7    Dombrowicz, D.8
  • 56
    • 0037716526 scopus 로고    scopus 로고
    • PPAR-α and γ but not -δ agonists inhibit airway inflammation in a murine model of asthma: In vitro evidence for an NF-κB-independent effect
    • Trifilieff A, Bench A, Hanley M, Bayley D, Campbell E, Whittacker P. PPAR-α and γ but not -δ agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-κB-independent effect. Br J Pharmacol 2003;139:163-171.
    • (2003) Br J Pharmacol , vol.139 , pp. 163-171
    • Trifilieff, A.1    Bench, A.2    Hanley, M.3    Bayley, D.4    Campbell, E.5    Whittacker, P.6
  • 58
    • 0032555196 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
    • Said JW, Heber D, Koeffter HP. Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA 1998;95:8806-8811.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8806-8811
    • Said, J.W.1    Heber, D.2    Koeffter, H.P.3
  • 59
    • 0032145363 scopus 로고    scopus 로고
    • Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo
    • Kubota T, Koshizuka K, Williamson EA, Asou H, Said JW, Holden S, Miyoshi I, Koeffler HP. Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res 1998; 58:3344-3352.
    • (1998) Cancer Res , vol.58 , pp. 3344-3352
    • Kubota, T.1    Koshizuka, K.2    Williamson, E.A.3    Asou, H.4    Said, J.W.5    Holden, S.6    Miyoshi, I.7    Koeffler, H.P.8


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