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Volumn 11, Issue 5, 2005, Pages 454-460

Sepsis and coagulation

Author keywords

Activated protein C; Protein C; Protein S; Sepsis; Tissue factor

Indexed keywords

PROTEIN C; PROTEIN S; PROTEINASE ACTIVATED RECEPTOR 1; THROMBOMODULIN; THROMBOPLASTIN; VON WILLEBRAND FACTOR;

EID: 26944501971     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/01.ccx.0000176692.03186.e7     Document Type: Review
Times cited : (25)

References (52)
  • 1
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709.
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 2
    • 3943060904 scopus 로고    scopus 로고
    • Thrombomodulin-Protein C-EPCR system. Integrated to regulate coagulation and inflammation
    • Van der Wouwer M, Collen D, Conway EM. Thrombomodulin-Protein C-EPCR system. Integrated to regulate coagulation and inflammation. Arteriscler Thromb Vasc Biol 2004; 24:1374-1383.
    • (2004) Arteriscler Thromb Vasc Biol , vol.24 , pp. 1374-1383
    • Van Der Wouwer, M.1    Collen, D.2    Conway, E.M.3
  • 3
    • 0033790726 scopus 로고    scopus 로고
    • Characterization of cleaved plasma protein S with a monoclonal antibody-based assay
    • Morboeuf O, Borgel D, Gaussem P, et al. Characterization of cleaved plasma protein S with a monoclonal antibody-based assay. Thromb Haemost 2000; 84:604-610.
    • (2000) Thromb Haemost , vol.84 , pp. 604-610
    • Morboeuf, O.1    Borgel, D.2    Gaussem, P.3
  • 4
    • 0035844272 scopus 로고    scopus 로고
    • Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C
    • Rezaie AR. Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C. J Biol Chem 2001; 276:15567-15570.
    • (2001) J Biol Chem , vol.276 , pp. 15567-15570
    • Rezaie, A.R.1
  • 5
    • 0035815747 scopus 로고    scopus 로고
    • Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
    • Joyce DE, Gelbert L, Ciaccia A, et al. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001; 276:11199-11203.
    • (2001) J Biol Chem , vol.276 , pp. 11199-11203
    • Joyce, D.E.1    Gelbert, L.2    Ciaccia, A.3
  • 6
    • 0036339949 scopus 로고    scopus 로고
    • Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes
    • Yuksel M, Okajima K, Uchiba M, et al. Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes. Thromb Haemost 2002; 88:267-273.
    • (2002) Thromb Haemost , vol.88 , pp. 267-273
    • Yuksel, M.1    Okajima, K.2    Uchiba, M.3
  • 7
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • Riewald M, Petrovan RJ, Donner A, et al. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 2002; 296: 1880-1882.
    • (2002) Science , vol.296 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3
  • 8
    • 0037349926 scopus 로고    scopus 로고
    • The thrombomodulin-protein C system is essential for the maintenance of pregnancy
    • Isermann B, Sood R, Pawlinski R, et al. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med 2003; 9:331-337.
    • (2003) Nat Med , vol.9 , pp. 331-337
    • Isermann, B.1    Sood, R.2    Pawlinski, R.3
  • 9
    • 0038682435 scopus 로고    scopus 로고
    • Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor
    • Mosnier LO, Griffin JH. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. Biochem J 2003; 373: 65-70.
    • (2003) Biochem J , vol.373 , pp. 65-70
    • Mosnier, L.O.1    Griffin, J.H.2
  • 10
    • 0038115229 scopus 로고    scopus 로고
    • Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1
    • Domotor E, Benzakour O, Griffin JH, et al. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood 2003; 101: 4797-4801.
    • (2003) Blood , vol.101 , pp. 4797-4801
    • Domotor, E.1    Benzakour, O.2    Griffin, J.H.3
  • 11
    • 0141609935 scopus 로고    scopus 로고
    • Inflammation and thrombosis
    • Esmon CT. Inflammation and thrombosis. J Thromb Haemost 2003; 1: 1343-1348.
    • (2003) J Thromb Haemost , vol.1 , pp. 1343-1348
    • Esmon, C.T.1
  • 12
    • 0036719075 scopus 로고    scopus 로고
    • The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways
    • Conway EM, Van de Wouwer M, Pollefeyt S, et al. The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways. J Exp Med 2002; 196:565-577.
    • (2002) J Exp Med , vol.196 , pp. 565-577
    • Conway, E.M.1    Van De Wouwer, M.2    Pollefeyt, S.3
  • 13
    • 0037352279 scopus 로고    scopus 로고
    • Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
    • Cheng T, Liu D, Griffin JH, et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 2003; 9:338-342.
    • (2003) Nat Med , vol.9 , pp. 338-342
    • Cheng, T.1    Liu, D.2    Griffin, J.H.3
  • 14
    • 13544267425 scopus 로고    scopus 로고
    • Activated protein C induces the release of microparticle-associated endothelial protein C receptor
    • Perez-Casal M, Downey C, Fukudome K, et al. Activated protein C induces the release of microparticle-associated endothelial protein C receptor. Blood 2005; 105:1515-1522. The authors describe a new form of EPCR and APC-containing microparticles able to exert anticoagulant activity. Moreover, APC induces the release of these potentially beneficial microparticles.
    • (2005) Blood , vol.105 , pp. 1515-1522
    • Perez-Casal, M.1    Downey, C.2    Fukudome, K.3
  • 15
    • 4444331574 scopus 로고    scopus 로고
    • Activated protein C variants with normal cytoprotective but reduced anticoagulant activity
    • Mosnier LO, Gale AJ, Yegneswaran S, et al. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity. Blood 2004; 104: 1740-1744. Utilization of such variants could prevent hemorrhagic complications of APC with preserved antiapoptotic and antiinflammatory functions.
    • (2004) Blood , vol.104 , pp. 1740-1744
    • Mosnier, L.O.1    Gale, A.J.2    Yegneswaran, S.3
  • 16
    • 17044427680 scopus 로고    scopus 로고
    • Endothelial barrier protection by activated protein C through PAR1-dependant sphingosme 1-phosphate receptor-1 crossactivation
    • Feistritzer C, Riewald M. Endothelial barrier protection by activated protein C through PAR1-dependant sphingosme 1-phosphate receptor-1 crossactivation. Blood 2005; 105:3178-3184. This is the first description of the intracellular signaling pathways explaining the differential PAR1-mediated cellular effects of protein C and FIIa. This study opens the way for future therapeutic developments.
    • (2005) Blood , vol.105 , pp. 3178-3184
    • Feistritzer, C.1    Riewald, M.2
  • 17
    • 17044433166 scopus 로고    scopus 로고
    • APC signaling: Tickling PAR1 for barrier protection?
    • Camerer E, Coughlin SR. APC signaling: tickling PAR1 for barrier protection? Blood 2005; 105:3004-3005.
    • (2005) Blood , vol.105 , pp. 3004-3005
    • Camerer, E.1    Coughlin, S.R.2
  • 18
    • 14144250943 scopus 로고    scopus 로고
    • Effects of TNF-a and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells
    • Nan B, Lin P, Lumsden AB, et al. Effects of TNF-a and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Thromb Res 2005; 115:417-426.
    • (2005) Thromb Res , vol.115 , pp. 417-426
    • Nan, B.1    Lin, P.2    Lumsden, A.B.3
  • 19
    • 1842637573 scopus 로고    scopus 로고
    • Microhemodynamic and cellular mechanisms of activated protein C during endotoxemia
    • Hoffmann JN, Vollma B, Laschke MW, et al. Microhemodynamic and cellular mechanisms of activated protein C during endotoxemia. Crit Care Med 2004; 32:1011-1017.
    • (2004) Crit Care Med , vol.32 , pp. 1011-1017
    • Hoffmann, J.N.1    Vollma, B.2    Laschke, M.W.3
  • 20
    • 13444303827 scopus 로고    scopus 로고
    • Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model
    • Iba T, Kidokoro A, Fukunaga M, et al. Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model. Crit Care Med 2005; 33:368-372.
    • (2005) Crit Care Med , vol.33 , pp. 368-372
    • Iba, T.1    Kidokoro, A.2    Fukunaga, M.3
  • 21
    • 12544253819 scopus 로고    scopus 로고
    • Activated protein C, a natural anticoagulant protein, has antioxydant properties and inhibits lipid peroxydation and advanced glycation end products formation
    • Yamaji K, Wang Y, Liu Y, et al. Activated protein C, a natural anticoagulant protein, has antioxydant properties and inhibits lipid peroxydation and advanced glycation end products formation. Thromb Res 2005; 115:319-325.
    • (2005) Thromb Res , vol.115 , pp. 319-325
    • Yamaji, K.1    Wang, Y.2    Liu, Y.3
  • 22
    • 2642533647 scopus 로고    scopus 로고
    • The C4b-binding Protein-Protein S complex inhibits the phagocytosis of apoptotic cells
    • Kask L, Trouw LA, Dahlback B, et al. The C4b-binding Protein-Protein S complex inhibits the phagocytosis of apoptotic cells. J Biol Chem 2004; 279: 23869-23873.
    • (2004) J Biol Chem , vol.279 , pp. 23869-23873
    • Kask, L.1    Trouw, L.A.2    Dahlback, B.3
  • 23
    • 3042839778 scopus 로고    scopus 로고
    • Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow
    • Bernardo A, Ball C, Nolasco L, et al. Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow. Blood 2004; 104:100-106. This study explores a new mechanism linking inflammation and initiation of coagulation, implicating von Willebrand factor and ADAMTS13.
    • (2004) Blood , vol.104 , pp. 100-106
    • Bernardo, A.1    Ball, C.2    Nolasco, L.3
  • 24
    • 3843070946 scopus 로고    scopus 로고
    • A TREM family member, TLT-1, is found exclusively in the α-granules of megakaryocytes and platelets
    • Washington AV, Schubert RL, Quigley L, et al. A TREM family member, TLT-1, is found exclusively in the α-granules of megakaryocytes and platelets. Blood 2004; 104:1042-1047.
    • (2004) Blood , vol.104 , pp. 1042-1047
    • Washington, A.V.1    Schubert, R.L.2    Quigley, L.3
  • 25
    • 4444314278 scopus 로고    scopus 로고
    • Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium
    • Chen D, Giannopoulos K, Shiels PG, et al. Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium. Blood 2004; 104: 1344-1349.
    • (2004) Blood , vol.104 , pp. 1344-1349
    • Chen, D.1    Giannopoulos, K.2    Shiels, P.G.3
  • 26
    • 26944493218 scopus 로고    scopus 로고
    • Cell surface-targeted anticoagulation in systemic infection and inflammation
    • Levi M. Cell surface-targeted anticoagulation in systemic infection and inflammation. Blood 2004; 104:1231-1232.
    • (2004) Blood , vol.104 , pp. 1231-1232
    • Levi, M.1
  • 27
    • 10244229104 scopus 로고    scopus 로고
    • Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis
    • Nick JA, Coldren CD, Geraci MW, et al. Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis. Blood 2004; 104:3878-3885.
    • (2004) Blood , vol.104 , pp. 3878-3885
    • Nick, J.A.1    Coldren, C.D.2    Geraci, M.W.3
  • 28
    • 19744376844 scopus 로고    scopus 로고
    • APC: Braking neutrophils to benefit patients?
    • Mizgerd JP. APC: braking neutrophils to benefit patients? Blood 2004; 104: 3841.
    • (2004) Blood , vol.104 , pp. 3841
    • Mizgerd, J.P.1
  • 29
    • 18644373364 scopus 로고    scopus 로고
    • Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans
    • Van der Poll T, Levi M, Nick JA, et al. Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans. Am J Respir Crit Care Med 2005; 171:1125-1128.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 1125-1128
    • Van Der Poll, T.1    Levi, M.2    Nick, J.A.3
  • 30
    • 3042571475 scopus 로고    scopus 로고
    • Effects of drotrecogin alfa (activated) in human endotoxemia
    • Kalil AC, Coyle SM, Um JY, et al. Effects of drotrecogin alfa (activated) in human endotoxemia. Shock 2004; 21:222-229.
    • (2004) Shock , vol.21 , pp. 222-229
    • Kalil, A.C.1    Coyle, S.M.2    Um, J.Y.3
  • 32
    • 21544459590 scopus 로고    scopus 로고
    • Intracellular and surface distribution of monocyte tissue factor. Application to intersubject variability
    • Egorina EM, Sovershaev MA, Bjorkoy G, et al. Intracellular and surface distribution of monocyte tissue factor. Application to intersubject variability. Arterioscler Thromb Vasc Biol 2005; 25:1-7.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1-7
    • Egorina, E.M.1    Sovershaev, M.A.2    Bjorkoy, G.3
  • 33
    • 3042592600 scopus 로고    scopus 로고
    • Highly purified lipoteichoic acid from Staphylococcus aureus induces procoagulant activity and tissue factor expression in human monocytes but is a weak inducer in whole blood: Comparison with peptidoglycan
    • Mattson E, Hartung T, Morath S, et al. Highly purified lipoteichoic acid from Staphylococcus aureus induces procoagulant activity and tissue factor expression in human monocytes but is a weak inducer in whole blood: comparison with peptidoglycan. Infect Immun 2004; 72:4322-4326.
    • (2004) Infect Immun , vol.72 , pp. 4322-4326
    • Mattson, E.1    Hartung, T.2    Morath, S.3
  • 34
    • 0038690407 scopus 로고    scopus 로고
    • Efficacy and safety of Tifagocin (Recombinant tissue factor pathway inhibitor) in severe sepsis: A randomized controlled trial
    • Abraham E, Reinhart K, Svoboda P, et al. Efficacy and safety of Tifagocin (Recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA 2003; 290:238-247.
    • (2003) JAMA , vol.290 , pp. 238-247
    • Abraham, E.1    Reinhart, K.2    Svoboda, P.3
  • 35
    • 10244250329 scopus 로고    scopus 로고
    • Patients with severe sepsis vary markedly in their ability to generate activated protein C
    • Liaw PC, Esmon CT, Kahnamoui K, et al. Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood 2004; 104: 3958-3964. Mainly using protein C and APC dosages, arguments for an impaired process of protein C activation was found in 12 of 32 severe sepsis patients, with a negative correlation with survival. This study opens important perspectives for the respective utilizations of protein C and APC in severe sepsis.
    • (2004) Blood , vol.104 , pp. 3958-3964
    • Liaw, P.C.1    Esmon, C.T.2    Kahnamoui, K.3
  • 36
    • 1842547895 scopus 로고    scopus 로고
    • Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation
    • Dhainaut JF, Yan SB, Joyce DE, et al. Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation. J Thromb Haemost 2004; 2:1924-1933.
    • (2004) J Thromb Haemost , vol.2 , pp. 1924-1933
    • Dhainaut, J.F.1    Yan, S.B.2    Joyce, D.E.3
  • 37
    • 8544268686 scopus 로고    scopus 로고
    • The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis
    • Angus DC, Laterre PF, Helterbrand J, et al. The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis. Crit Care Med 2004; 32:2199-2206.
    • (2004) Crit Care Med , vol.32 , pp. 2199-2206
    • Angus, D.C.1    Laterre, P.F.2    Helterbrand, J.3
  • 38
    • 8544284118 scopus 로고    scopus 로고
    • Hospital mortality and resource use in subgroups of the recombinant human activated Protein C worldwide evaluation in severe sepsis (PROWESS) trial
    • Laterre PF, Levy H, Clermont G, et al. Hospital mortality and resource use in subgroups of the recombinant human activated Protein C worldwide evaluation in severe sepsis (PROWESS) trial. Crit Care Med 2004; 32: 2207-2218.
    • (2004) Crit Care Med , vol.32 , pp. 2207-2218
    • Laterre, P.F.1    Levy, H.2    Clermont, G.3
  • 39
    • 10644277923 scopus 로고    scopus 로고
    • Sources of variability on the estimate of treatment effect in the PROWESS trial: Implications for the design and conduct of future studies in severe sepsis
    • Macias WL, Vallet B, Bernard GR, et al. Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis. Crit Care Med 2004; 32:2385-2391.
    • (2004) Crit Care Med , vol.32 , pp. 2385-2391
    • Macias, W.L.1    Vallet, B.2    Bernard, G.R.3
  • 40
    • 1842600276 scopus 로고    scopus 로고
    • Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism
    • Kinasewitz GT, Yan SB, Basson B, et al. Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism. Crit Care 2004; 8:82-90.
    • (2004) Crit Care , vol.8 , pp. 82-90
    • Kinasewitz, G.T.1    Yan, S.B.2    Basson, B.3
  • 41
    • 17444406333 scopus 로고    scopus 로고
    • Protein C levels can be forcasted by global haemostatic tests in critically ill patients and predict long-term survival
    • Nilsson G, Astermark J, Lethagen S, et al. Protein C levels can be forcasted by global haemostatic tests in critically ill patients and predict long-term survival. Thromb Res 2005; 116:15-24.
    • (2005) Thromb Res , vol.116 , pp. 15-24
    • Nilsson, G.1    Astermark, J.2    Lethagen, S.3
  • 42
    • 10644283860 scopus 로고    scopus 로고
    • Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation
    • Bakhtiari K, Meijers JCM, de Jonge E, et al. Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med 2004; 32:2416-2421. This study is the first prospective validation of the ISTH DIC scoring system in the critical care setting.
    • (2004) Crit Care Med , vol.32 , pp. 2416-2421
    • Bakhtiari, K.1    Meijers, J.C.M.2    De Jonge, E.3
  • 43
    • 1242342711 scopus 로고    scopus 로고
    • Utility of activated partial thromboplastin time waveform analysis for identification of sepsis and overt disseminated intravascuiar coagulation in patients admitted to a surgical intensive care unit
    • Dempfle CEH, Lorenz S, Smolinski M, et al. Utility of activated partial thromboplastin time waveform analysis for identification of sepsis and overt disseminated intravascuiar coagulation in patients admitted to a surgical intensive care unit. Crit Care Med 2004; 32:520-524.
    • (2004) Crit Care Med , vol.32 , pp. 520-524
    • Dempfle, C.E.H.1    Lorenz, S.2    Smolinski, M.3
  • 44
    • 10644283857 scopus 로고    scopus 로고
    • Clinical implications of a validated scoring system for disseminated intravascular coagulation
    • Heslet L. Clinical implications of a validated scoring system for disseminated intravascular coagulation. Crit Care Med 2004; 32:2548-2549.
    • (2004) Crit Care Med , vol.32 , pp. 2548-2549
    • Heslet, L.1
  • 46
    • 13244283144 scopus 로고    scopus 로고
    • Platelets at a crossroad of pathogenic pathways in sepsis
    • Levi M. Platelets at a crossroad of pathogenic pathways in sepsis. J Thromb Haemost 2004; 2:2094-2095.
    • (2004) J Thromb Haemost , vol.2 , pp. 2094-2095
    • Levi, M.1
  • 47
    • 3943050737 scopus 로고    scopus 로고
    • Use of recombinant tissue plasminogen activator in children with meningococcal purpura fulminans: A retrospective study
    • Zenz W, Zoehrer B, Levin M, et al. Use of recombinant tissue plasminogen activator in children with meningococcal purpura fulminans: a retrospective study. Crit Care Med 2004; 32:1777-1780.
    • (2004) Crit Care Med , vol.32 , pp. 1777-1780
    • Zenz, W.1    Zoehrer, B.2    Levin, M.3
  • 48
    • 4444237509 scopus 로고    scopus 로고
    • Effect of long-term and high-dose antithrombin supplementation on coagulation and fibrinolysis in patients with severe sepsis
    • Hoffmann JN, Muhlbayer D, Jochum M, et al. Effect of long-term and high-dose antithrombin supplementation on coagulation and fibrinolysis in patients with severe sepsis. Crit Care Med 2004; 32:1851-1859.
    • (2004) Crit Care Med , vol.32 , pp. 1851-1859
    • Hoffmann, J.N.1    Muhlbayer, D.2    Jochum, M.3
  • 49
    • 0035904368 scopus 로고    scopus 로고
    • High dose antithrombin III in severe sepsis, a randomized controlled trial
    • Warren BL, Eid A, Singer P, et al. High dose antithrombin III in severe sepsis, a randomized controlled trial. JAMA 2001; 286:1869-1878.
    • (2001) JAMA , vol.286 , pp. 1869-1878
    • Warren, B.L.1    Eid, A.2    Singer, P.3
  • 50
    • 4444347405 scopus 로고    scopus 로고
    • Improvement in coagulation markers with antithrombin. Beneficial in severe sepsis?
    • Wiedermann CJ. Improvement in coagulation markers with antithrombin. Beneficial in severe sepsis? Crit Care Med 2004.
    • (2004) Crit Care Med
    • Wiedermann, C.J.1
  • 51
    • 0033554267 scopus 로고    scopus 로고
    • Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock
    • Westendorp RGJ, Hottenga JJ, Slagboom PE. Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock. Lancet 1999; 354:561-563.
    • (1999) Lancet , vol.354 , pp. 561-563
    • Westendorp, R.G.J.1    Hottenga, J.J.2    Slagboom, P.E.3
  • 52
    • 4444246103 scopus 로고    scopus 로고
    • A functional single nucleotide polymorphism in the thrombin-activatable fibrinolysis inhibitor (TAFI) gene associates with outcome of meningococcal disease
    • Hovinga JAK, Franco RF, Zago MA, et al. A functional single nucleotide polymorphism in the thrombin-activatable fibrinolysis inhibitor (TAFI) gene associates with outcome of meningococcal disease. J Thromb Haemost 2004; 2: 54-57.
    • (2004) J Thromb Haemost , vol.2 , pp. 54-57
    • Hovinga, J.A.K.1    Franco, R.F.2    Zago, M.A.3


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