Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brain

Gene Therapy

Volumn 7, Issue 15, 2000, Pages 1304-1311

  Paterna, J C ^a   Moccetti, T ^a   Mura, A ^b   Feldon, J ^b   Bueler H ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

Author keywords

Adeno associated virus; Parkinson's disease; PDGF promoter; Transduction; WPRE

Indexed keywords

GREEN FLUORESCENT PROTEIN; PLATELET DERIVED GROWTH FACTOR B; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; CYTOMEGALOVIRUS; DOPAMINERGIC NERVE CELL; GENE EXPRESSION REGULATION; HEPATITIS VIRUS; IN VIVO STUDY; MALE; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATOR GENE; TISSUE SPECIFICITY; TRANSGENE; VIRUS RECOMBINANT; VIRUS TRANSCRIPTION;

ADENO-ASSOCIATED VIRUS; ANIMALIA; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; DNA VIRUSES; MARMOTA MONAX; WOODCHUCK HEPATITIS B VIRUS;

EID: 0033870226     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301221     Document Type: Article

References (29)

1. Adeno-associated virus expression systems for gene transfer
2. Adeno-associated viral vectors for gene transfer and gene therapy
3. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector
4. Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus
5. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats
6. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors
7. In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector
8. Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector
9. Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers
10. Induction of immunity to antigens expressed by recombinant adeno-associated virus depends on the route of administration
11. Selective and rapid uptake of adeno-associated virus type 2 in brain
12. Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease
13. Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector
14. Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors
15. Long-term actions of vector-derived nerve growth factor or brain-derived neurotrophic factor on choline acetyl-transferase and Trk receptor levels in the adult rat basal forebrain
16. Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element
17. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
18. Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: Implications for gene therapy
19. PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model
20. The crossed nigrostriatal projection decussates in the ventral tegmental decussation
21. Gene transfer by adeno-associated virus vectors into the central nervous system
22. Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice
23. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain
24. Inactivation of the very strong HCMV immediate early promoter by DNA CpG methylation in vitro
25. Reactivation of the previously silenced cytomegalovirus major immediate-early promoter in the mouse liver: Involvement of NFkappaB
26. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
27. Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters
28. Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gene expression
29. Production of recombinant adeno-associated viral vectors