A novel SREBP-1 splice variant: Tissue abundance and transactivation potency

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1731, Issue 1, 2005, Pages 41-47

  Felder, Thomas Klaus ^a   Klein, Kerstin ^a   Patsch, Wolfgang ^a   Oberkofler, Hannes ^a  

^a PARACELSUS MEDICAL UNIVERSITY   (Austria)

Author keywords

Alternative splicing; SREBP 1; Transcriptional regulation

Indexed keywords

CHOLESTEROL; HELIX LOOP HELIX PROTEIN; LEUCINE; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR; UNCOUPLING PROTEIN 2;

ARTICLE; CELL CULTURE; CELL LINE; GENETIC CODE; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSACTIVATION;

ADIPOSE TISSUE; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BRAIN; CELL LINE; HUMANS; LIVER; MALE; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TESTIS; TISSUE DISTRIBUTION; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 26844571316     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbaexp.2005.08.004     Document Type: Article

References (33)

1. J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Invest. 109 2002 1125 1131
2. X. Hua, J. Wu, J.L. Goldstein, M.S. Brown, and H.H. Hobbs Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13 Genomics 25 1995 667 673
3. I. Shimomura, H. Shimano, J.D. Horton, J.L. Goldstein, and M.S. Brown Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells J. Clin. Invest. 99 1997 838 845
4. M.K. Bennett, J.I. Toth, and T.F. Osborne Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo J. Biol. Chem. 279 2004 37360 37367
5. H. Shimano, J.D. Horton, I. Shimomura, R.E. Hammer, M.S. Brown, and J.L. Goldstein Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells J. Clin. Invest. 99 1997 846 854
6. C. Yokoyama, X. Wang, M.R. Briggs, A. Admon, J. Wu, X. Hua, J.L. Goldstein, and M.S. Brown SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene Cell 75 1993 187 197
7. X. Hua, J. Sakai, M.S. Brown, and J.L. Goldstein Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane J. Biol. Chem. 271 1996 10379 10384
8. H. Wang, F. Liu, C.F. Millette, and D.L. Kilpatrick Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesis Mol. Cell. Biol. 22 2002 8478 8490
9. H. Wang, J.T. San Agustin, G.B. Witman, and D.L. Kilpatrick Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression Mol. Cell. Biol. 24 2004 10681 10688
10. R. Sato, J. Yang, X. Wang, M.J. Evans, Y.K. Ho, J.L. Goldstein, and M.S. Brown Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1) J. Biol. Chem. 269 1994 17267 17273
11. R.A. DeBose-Boyd, M.S. Brown, W.P. Li, A. Nohturfft, J.L. Goldstein, and P.J. Espenshade Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi Cell 99 1999 703 712
12. M. Amemiya-Kudo, H. Shimano, A.H. Hasty, N. Yahagi, T. Yoshikawa, T. Matsuzaka, H. Okazaki, Y. Tamura, Y. Iizuka, K. Ohashi, J. Osuga, K. Harada, T. Gotoda, R. Sato, S. Kimura, S. Ishibashi, and N. Yamada Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes J. Lipid Res. 43 2002 1220 1235
13. S. Datta, and T.F. Osborne Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers J. Biol. Chem. 280 2005 3338 3345
14. V. Zilberfarb, F. Pietri-Rouxel, R. Jockers, S. Krief, C. Delouis, T. Issad, and A.D. Strosberg Human immortalized brown adipocytes express functional beta3-adrenoceptor coupled to lipolysis J. Cell Sci. 110 Pt 7 1997 801 807
15. H. Esterbauer, C. Schneitler, H. Oberkofler, C. Ebenbichler, B. Paulweber, F. Sandhofer, G. Ladurner, E. Hell, A.D. Strosberg, J.R. Patsch, F. Krempler, and W. Patsch A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans Nat. Genet. 28 2001 178 183
16. H. Oberkofler, E. Schraml, F. Krempler, and W. Patsch Restoration of sterol-regulatory-element-binding protein-1c gene expression in HepG2 cells by peroxisome-proliferator-activated receptor-gamma co-activator-1alpha Biochem. J. 381 2004 357 363
17. J.I. Toth, S. Datta, J.N. Athanikar, L.P. Freedman, and T.F. Osborne Selective coactivator interactions in gene activation by SREBP-1a and -1c Mol. Cell. Biol. 24 2004 8288 8300
18. R.L. Strausberg, E.A. Feingold, L.H. Grouse, J.G. Derge, R.D. Klausner, F.S. Collins, L. Wagner, C.M. Shenmen, G.D. Schuler, S.F. Altschul, B. Zeeberg, K.H. Buetow, C.F. Schaefer, N.K. Bhat, R.F. Hopkins, H. Jordan, T. Moore, S.I. Max, J. Wang, F. Hsieh, L. Diatchenko, K. Marusina, A.A. Farmer, G.M. Rubin, L. Hong, M. Stapleton, M.B. Soares, M.F. Bonaldo, T.L. Casavant, T.E. Scheetz, M.J. Brownstein, T.B. Usdin, S. Toshiyuki, P. Carninci, C. Prange, S.S. Raha, N.A. Loquellano, G.J. Peters, R.D. Abramson, S.J. Mullahy, S.A. Bosak, P.J. McEwan, K.J. McKernan, J.A. Malek, P.H. Gunaratne, S. Richards, K.C. Worley, S. Hale, A.M. Garcia, L.J. Gay, S.W. Hulyk, D.K. Villalon, D.M. Muzny, E.J. Sodergren, X. Lu, R.A. Gibbs, J. Fahey, E. Helton, M. Ketteman, A. Madan, S. Rodrigues, A. Sanchez, M. Whiting, A. Madan, A.C. Young, Y. Shevchenko, G.G. Bouffard, R.W. Blakesley, J.W. Touchman, E.D. Green, M.C. Dickson, A.C. Rodriguez, J. Grimwood, J. Schmutz, R.M. Myers, Y.S. Butterfield, M.I. Krzywinski, U. Skalska, D.E. Smailus, A. Schnerch, J.E. Schein, S.J. Jones, and M.A. Marra Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences Proc. Natl. Acad. Sci. U. S. A. 99 2002 16899 16903
19. J.M. Lopez, M.K. Bennett, H.B. Sanchez, J.M. Rosenfeld, and T.E. Osborne Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid Proc. Natl. Acad. Sci. U. S. A. 93 1996 1049 1053
20. S.M. Jackson, J. Ericsson, J.E. Metherall, and P.A. Edwards Role for sterol regulatory element binding protein in the regulation of farnesyl diphosphate synthase and in the control of cellular levels of cholesterol and triglyceride: evidence from sterol regulation-defective cells J. Lipid Res. 37 1996 1712 1721
21. M.K. Bennett, J.M. Lopez, H.B. Sanchez, and T.F. Osborne Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways J. Biol. Chem. 270 1995 25578 25583
22. A.V. Medvedev, J. Robidoux, X. Bai, W. Cao, L.M. Floering, K.W. Daniel, and S. Collins Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid J. Biol. Chem. 277 2002 42639 42644
23. M. Foretz, C. Pacot, I. Dugail, P. Lemarchand, C. Guichard, X. Le Liepvre, C. Berthelier-Lubrano, B. Spiegelman, J.B. Kim, P. Ferre, and F. Foufelle ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose Mol. Cell. Biol. 19 1999 3760 3768
24. J.B. Kim, P. Sarraf, M. Wright, K.M. Yao, E. Mueller, G. Solanes, B.B. Lowell, and B.M. Spiegelman Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1 J. Clin. Invest. 101 1998 1 9
25. P. Tontonoz, J.B. Kim, R.A. Graves, and B.M. Spiegelman ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation Mol. Cell. Biol. 13 1993 4753 4759
26. W.Y. Ong, C.Y. Hu, Y.P. Soh, T.M. Lim, P.G. Pentchev, and S.C. Patel Neuronal localization of sterol regulatory element binding protein-1 in the rodent and primate brain: a light and electron microscopic immunocytochemical study Neuroscience 97 2000 143 153
27. L. Puglielli, R.E. Tanzi, and D.M. Kovacs Alzheimer's disease: the cholesterol connection Nat. Neurosci. 6 2003 345 351
28. C. Spell, H. Kolsch, D. Lutjohann, A. Kerksiek, F. Hentschel, M. Damian, K. von Bergmann, M.L. Rao, W. Maier, and R. Heun SREBP-1a polymorphism influences the risk of Alzheimer's disease in carriers of the ApoE4 allele Dement. Geriatr. Cogn. Disord. 18 2004 245 249
29. K. Fon Tacer, S. Kalanj-Bognar, M.R. Waterman, and D. Rozman Lanosterol metabolism and sterol regulatory element binding protein (SREBP) expression in male germ cell maturation J. Steroid Biochem. Mol. Biol. 85 2003 429 438
30. S. Grimsby, H. Jaensson, A. Dubrovska, M. Lomnytska, U. Hellman, and S. Souchelnytskyi Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity FEBS Lett. 577 2004 93 100
31. G.J. Botma, D. van Deursen, D. Vieira, M. van Hoek, H. Jansen, and A.J. Verhoeven Sterol-regulatory-element binding protein inhibits upstream stimulatory factor-stimulated hepatic lipase gene expression Atherosclerosis 179 2005 61 67
32. Y.S. Lee, H.H. Lee, J. Park, E.J. Yoo, C.A. Glackin, Y.I. Choi, S.H. Jeon, R.H. Seong, S.D. Park, and J.B. Kim Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c Nucleic Acids Res. 31 2003 7165 7174
33. W. Shea-Eaton, D. Lopez, and M.P. McLean Yin yang 1 protein negatively regulates high-density lipoprotein receptor gene transcription by disrupting binding of sterol regulatory element binding protein to the sterol regulatory element Endocrinology 142 2001 49 58