Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 23, 2005, Pages 5120-5123

  Tolkatchev, Dmitri ^a   Vinogradova, Anna ^a   Ni, Feng ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Bivalency; Control of molecular binding; Enzyme inhibitors; Polypeptide design

Indexed keywords

LIGAND; POLYPEPTIDE; THROMBIN INHIBITOR;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEINS; SERINE PROTEINASE INHIBITORS; THROMBIN;

EID: 26844488807     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.085     Document Type: Article

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