Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: New lead compounds for the development of anticancer agents

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 23, 2005, Pages 5170-5175

  Gobec, Stanislav ^a   Brožič, Petra ^a   Rižner, Tea Lanišnik ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

AKR1C3 inhibitors; Anti inflammatory drugs; Anticancer agents; Cancer chemoprevention

Indexed keywords

2 AMINOBENZAMIDE; 3 PHENOXYBENZOIC ACID; ACETYLSALICYLIC ACID; ALDEHYDE KETONE REDUCTASE; ALDEHYDE REDUCTASE; ANTHRANILIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; BENZOIC ACID DERIVATIVE; BENZOPHENONE DERIVATIVE; DICLOFENAC; ETODOLAC; IBUPROFEN; KETOPROFEN; N (2 PHENOXYACETYL)ANTHRANILIC ACID; N BENZOYLANTHRANILIC ACID; N PHTHALOYLANTHRANILIC ACID; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OXIDOREDUCTASE INHIBITOR; PARACETAMOL; PHENACETIN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

3-HYDROXYSTEROID DEHYDROGENASES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; MOLECULAR STRUCTURE; TUMOR CELLS, CULTURED;

EID: 26844480987     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.063     Document Type: Article

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