Phytoestrogens inhibit human 17β-hydroxysteroid dehydrogenase type 5

Molecular and Cellular Endocrinology

Volumn 171, Issue 1-2, 2001, Pages 151-162

  Krazeisen, A ^a   Breitling, R ^a   Moller G ^a   Adamski, J ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

18 Glycyrrhetinic acid; Flavonoids; Hydroxysteroid dehydrogenase; Phytoestrogens

Indexed keywords

3 HYDROXYFLAVONE; 3,7 DIHYDROXYFLAVONE; 5 METHOXYFLAVONE; 7 HYDROXYFLAVONE; ABIETIC ACID; ANDROSTENEDIONE; APIGENIN; AROMATASE; AROMATASE INHIBITOR; BIOCHANIN A; CHRYSIN; COUMARIN; COUMARIN DERIVATIVE; COUMESTAN DERIVATIVE; COUMESTROL; DAIDZEIN; DIETHYLSTILBESTROL; ENZYME INHIBITOR; FLAVANONE; FLAVONE; FLAVONE DERIVATIVE; FLAVONOID; GENISTEIN; GLYCYRRHETINIC ACID; ISOENZYME; ISOFLAVONE DERIVATIVE; KAEMPFEROL; NARINGENIN; PHYTOESTROGEN; PRIMULETIN; QUERCETIN; TAMOXIFEN; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; TESTOSTERONE 17BETA DEHYDROGENASE 5; TESTOSTERONE 17BETA DEHYDROGENASE INHIBITOR; UNCLASSIFIED DRUG; ZEARALENONE;

ANDROGEN METABOLISM; ARTICLE; BINDING SITE; CANCER; CONTROLLED STUDY; DIET; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ESCHERICHIA COLI; ESTROGEN METABOLISM; GENETIC TRANSFECTION; HORMONE DEPENDENCE; HUMAN; HYDROPHILICITY; HYDROXYLATION; NONHUMAN; OXIDATION; PH; PRIORITY JOURNAL; REDUCTION; STRUCTURE ACTIVITY RELATION;

17-HYDROXYSTEROID DEHYDROGENASES; AROMATASE INHIBITORS; BINDING SITES; BREAST NEOPLASMS; COUMESTROL; DIET; ENZYME INHIBITORS; ESTROGENS; ESTROGENS, NON-STEROIDAL; FEMALE; GENE EXPRESSION; GENISTEIN; GLYCYRRHETINIC ACID; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROXYLATION; ISOENZYMES; ISOFLAVONES; MALE; MODELS, MOLECULAR; OXIDATION-REDUCTION; PHYTOESTROGENS; PLANT PREPARATIONS; PROSTATIC NEOPLASMS; QUERCETIN; RECOMBINANT PROTEINS; SOYBEANS; TESTOSTERONE; ZEARALENONE;

EID: 0035931322     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(00)00422-6     Document Type: Article

References (45)

1. A guide to 17β-hydroxysteroid dehydrogenases
2. Assignment of estradiol-17β dehydrogenase and of estrone reductase to cytoplasmic structures of porcine endometrium cells
3. Epidemiology of phytoestrogens
4. Plasma concentrations of phyto-oestrogens in Japanese men
5. Determination of lignans and isoflavonoids in plasma by isotope dilution gas chromatography-mass spectrometry
6. Reduction of serum testosterone in men by licorice
7. Soybeans inhibit mammary tumors in models of breast cancer
8. Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3α-hydroxysteroid/dihydrodiol dehydrogenase
9. Latent carcinoma of prostate at autopsy in seven areas
10. Characteristics of a highly labile human type 5 17β-hydroxysteroid dehydrogenase
11. Localization of type 5 17β-hydroxysteroid dehydrogenase, 3β-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry
12. Structural features of the aldose reductase and aldehyde reductase inhibitor-binding sites
13. Review: prostate cancer epidemiology
14. The phytoestrogen congeners of alcoholic beverages: current status
15. Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture
16. SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling
17. Distribution of flavonoids in leguminosae
18. The prostate: development and physiology
19. Coumestrol content of fractions obtained during wet processing of alfalfa
20. Determination of cDNA, gene structure and chromosomal localization of the novel human 17β-hydroxysteroid dehydrogenase type 7
21. Dietary phytoestrogens
22. The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
23. Identification of isoflavonoids in beer
24. Porcine 80-kDa protein reveals intrinsic 17β-hydroxysteroid dehydrogenase, fatty acyl-CoA-hydratase/dehydrogenase, and sterol transfer activities
25. Expression and characterization of recombinant type 2 3 α-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 α/17β-HSD activity and cellular
26. Estrogen-specific 17β-hydroxysteroid oxidoreductase type I (E.C. 1.1.1.62) as a possible target for the action of phytoestrogens
27. Inhibition of 17β-hydroxysteroid oxidoreductase by flavonoids in breast and prostate cancer cells
28. Phytoestrogen content in foods
29. Estrogenic flavonoids: structural requirements for biological activity
30. Peroxisome targeting of porcine 17β-hydroxysteroid dehydrogenase type IV/D-specific multifunctional protein 2 is mediated by its C-terminal tripeptide AKI
31. Immunocytochemical localization of type 5 l7β-hydroxysteroid dehydrogenase in human reproductive tissues
32. Molecular determinants of steroid recognition and catalysis in aldo-keto reductases. Lessons from 3α-hydroxysteroid dehydrogenase
33. Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene
34. Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation
35. Genistein inhibits both estrogen and growth factor stimulated proliferation of human breast cancer cells
36. Isolation and identification of phytoestrogens from beer
37. Mutagenesis of 3α-hydroxysteroid dehydrogenase reveals a 'push-pull' mechanism for proton transfer in aldo-keto reductases
38. Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles county
39. Dietary phytoestrogens and their role in hormonally dependent disease
40. Diet, micronutrients, and the prostate gland
41. Naturally occurring estrogens in plant foodstuffs - a review
42. Endogenous inhibitors of 11β-hydroxysteroid dehydrogenase in hypertension
43. Geographic pathology of latent prostatic carcinoma