Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site

Archives of Biochemistry and Biophysics

Volumn 442, Issue 2, 2005, Pages 169-179

  Grimsley, Janet K ^a   Calamini, Barbara ^b   Wild, James R ^a   Mesecar, Andrew D ^b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Allosteric site; Allostery; Chemical warfare agents; Competitive inhibition; Non competitive inhibition; Phosphotriesterase; X ray crystallography

Indexed keywords

ORGANOPHOSPHORUS COMPOUND; PHOSPHONIC ACID DERIVATIVE;

ALLOSTERISM; ARTICLE; BINDING SITE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HYDROLYSIS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING; X RAY ANALYSIS;

ALLOSTERIC SITE; AMINO ACID SUBSTITUTION; ANIMALS; ARYLDIALKYLPHOSPHATASE; CHEMICAL WARFARE AGENTS; CRYSTALLOGRAPHY, X-RAY; HUMANS; ORGANOPHOSPHORUS COMPOUNDS; POINT MUTATION; PROTEIN STRUCTURE, QUATERNARY; SUBSTRATE SPECIFICITY;

EID: 26844462157     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2005.08.012     Document Type: Article

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