Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-κB

Diabetologia

Volumn 42, Issue 2, 1999, Pages 222-232

  Hofmann, M A ^a   Schiekofer, S ^a   Isermann, B ^a   Kanitz, M ^a   Henkels, M ^a   Joswig, M ^a   Treusch, A ^a   Morcos, M ^a   Weiss, T ^a   Borcea, V ^a   Abdel Khalek, A K M ^a   Amiral, J ^c   Tritschler, H ^b   Ritz, E ^a   Wahl, P ^a   Ziegler, R ^a   Bierhaus, A ^a   Nawroth, P P ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ASTA MEDICA AG   (Germany)

^c Department of Internal Medicine I ^*

Author keywords

Nephropathy; Oxidative stress; Thioctic acid; Thrombomodulin; Transcription factor NF B

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; THIOCTIC ACID; THROMBOMODULIN; TRANSCRIPTION FACTOR;

ADULT; AGED; ARTICLE; BINDING AFFINITY; CLINICAL ARTICLE; DIABETIC NEPHROPATHY; ELECTROPHORETIC MOBILITY; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; GENE TRANSLOCATION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERLIPIDEMIA; IMMUNOHISTOLOGY; MALE; MEDIATOR RELEASE; MONONUCLEAR CELL; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADULT; ALBUMINURIA; ANTIOXIDANTS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; NF-KAPPA B; OXIDATIVE STRESS; THIOCTIC ACID; THROMBOMODULIN;

EID: 0032897751     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051142     Document Type: Article

References (59)

1. 1. Baynes JW (1991) Role of oxidative stress in development of complications in diabetes. Diabetes 40: 405-412
2. 2. Nourooz-Zadeh J, Rahimi A, Tajaddini-Sarmadi J et al. (1997) Relationship between plasma measures of oxidative stress and metabolic control in non-insulin-dependent diabetes mellitus. Diabetologia 40: 647-654
3. 3. Godin DV, Wohaieb SA, Garnett ME, Goumeniouk AD (1988) Antioxidant enzyme alterations in experimental and clinical diabetes. Mol Cell Biochem 84: 223-231
4. 4. Giugliano D, Ceriello A, Paolisso G (1995) Diabetes mellitus, hypertension, and cardiovascular disease: which role for oxidative stress? Metabolism 44: 363-368
5. 5. Rema M, Mohan V, Bhaskar A, Shanmugasundaram KR (1995) Does oxidant stress play a role in diabetic retinopathy? Indian J Opthalmol 43: 17-21
6. 6. Salahudeen AK, Kanji V, Reckelhoff JF, Schmidt AM (1997) Pathogenesis of diabetic nephropathy: a radical approach. Nephrol Dial Transplant 12: 664-668
7. 7. Ha H, Kim KH (1995) Role of oxidative stress in the development of diabetic nephropathy. Kidney Int Suppl 51:S18-21
8. 8. Ha H, Lee SH, Kim KH (1997) Effects of rebamipide in a model of experimental diabetes and on the synthesis of transforming growth factor-beta and fibronectin, and lipid peroxidation induced by high glucose in cultured mesangial cells. J Pharmacol Exp Ther 281: 1457-1462
9. 9. Aoki Y, Yazaki K, Shirotori K et al. (1993) Stiffening of connective tissue in elderly diabetic patients: relevance to diabetic nephropathy and oxidative stress. Diabetologia 36: 79-83
10. 10. Kakkar R, Mantha SV, Radhi J, Prasad K, Kalra J (1997) Antioxidant defense system in diabetic kidney: a time course study. Life Sci 60: 667-679
11. 11. Schlöndorff D (1996) Roles of the mesangium in glomerular function. Kidney Int 49: 1583-1585
12. 12. Collins T (1993) Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion. Lab Invest 68: 499-508
13. 13. Guijarro C, Kim Y, Kasiske BL et al. (1997) Central role of the transcription factor nuclear factor-kappa B in mesangial cell production of chemokines. Contrib Nephrol 120: 210-218
14. 14. Barnes PJ, Karin M (1997) Nuclear Factor-κB - a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336: 1066-1071
15. 15. Schmidt AM, Hori O, Chen JX et al. (1995) Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. J Clin Invest 96: 1395-1403
16. 16. Bierhaus A, Chevion S, Chevion M et al. (1997) Advanced glycation endproducts (AGEs) induced activation of NF-κB is suppressed by α-lipoic acid in cultured endothelial cells. Diabetes 46: 1481-1490
17. 17. Schmidt AM, Yan SD, Stern DM (1995) The dark side of glucose. Nat Med 1: 1002-1004
18. 18. Quehenberger P, Bierhaus A, Fasching P et al. (1997) Induction of endothelin-1 through erythrocytes of patients with diabetes mellitus. Thromb Haemost 77 [Suppl 1]:458 (Abstract)
19. 19. Amoah-Apraku B, Chandler LJ, Harrison JK, Tang SS, Ingelfinger JR, Guzman NJ (1995) NF-κB and transcriptional control of renal epithelial-inducible nitric oxide synthase. Kidney Int 48: 674-682
20. 20. Rovin BH, Dickerson JA, Tan LC, Hebert CA (1995) Activation of nuclear factor-κB correlates with MCP-1 expression by human mesangial cells. Kidney Int 48: 1263-1271
21. 21. Combe C, Burton CJ, Dufourco P (1997) Hypoxia induces intercellular adhesion molecule-1 on cultured human tubular cells. Kidney Int 51: 1703-1709
22. 22. Khachigan LM, Collins T, Fries JW (1995) Nuclear factor-kappa B mediates induction of vascular cell adhesion molecules in glomerular mesangial cells. Biochem Biophys Res Commun 206: 462-467
23. 23. Satriano J, Schlöndorff D (1994) Activation and attenuation of transcription factor NF-κB in mouse glomerular mesangial cells in response to tumor necrosis factor-α, immunglobulin G and adenosine 3′5′-cyclic monophosphate. J Clin Invest 94: 1629-1636
24. 24. Bierhaus A, Hofmann MA, Ziegler R, Nawroth PP (1998) The AGE/RAGE pathway in vascular disease and diabetes mellitus. Part I: The AGE-concept. Cardiovasc Res 37: 586-600
25. 25. Bierhaus A, Illmer T, Kasper M et al. (1997) Advanced glycation endproducts (AGEs) mediated induction of tissue factor in cultured endothelial cells is dependent on RAGE. Circulation 96: 2262-2271
26. 26. Böhrer H, Qiu F, Zimmermann T et al. (1997) Role of NFB in the mortality of sepsis. J Clin Invest 100: 974-982
27. 27. Douvedevani A, Abramson O, Tamir A, Konforty A, Isakov N, Chaimovitz C (1995) Commercial dialysate inhibits TNFα mRNA expression and NF-κB DNA-binding activity in LPS-stimulated macrophages. Kidney Int 47: 1537-1545
28. 28. Bierhaus A, Kasper M, Langer S et al. (1997) Activation of the transcription factor NF-κB in kidneys of diabetic rats. Exp Clin Endocrinol Diabetes 105 [Suppl 1]:15 (Abstract)
29. 29. Hofmann MA, Schiekofer S, Kanitz M et al. (1998) Insufficient glycaemic control increases NF-κB binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes. Diabetes Care 21: 1-7
30. 30. Packer L (1993) The role of anti-oxidative treatment of diabetes mellitus. Diabetologia 36: 1212-1213
31. 31. Packer L, Witt EH, Tritschler HJ (1995) Alpha-Lipoic acid as a biological antioxidant. Free Radical Biology & Medicine 19: 227-250
32. 32. Suzuki YJ, Aggarwal BB, Packer L (1992) Alpha-lipoic acid is a potent inhibitor of NF-kappa B activation in human T cells. Biochem Biophys Res Commun 189: 1709-1715
33. 33. Gabat S, Keller C, Kempe H-P et al. (1996) Plasma thrombomodulin: a marker of vascular complications in diabetes. Vasa 25: 233-241
34. 34. Brand K, Page S, Rogler G et al. (1996) Activated transcripton factor-kappa B is present in the atherosclerotic lesion. J Clin Invest 97: 1715-1722
35. 35. Rothbarth HP, Hendriks-Sturkenboom I, Ploem J (1976) Identification of monocytes in suspension of mononuclear cells. Blood 48: 139-147
36. 36. Pertoft H, Johnsson A, Wärmegard B, Seljelid R (1980) Separation of human monocytes on density gradients of percoll. J Immunol Methods 33: 221-229
37. 37. Hölschermann H, Dürfeld F, Maus U et al. (1997) Cyclosporine A inhibits tissue factor expression in monocytes/macrophages. Blood 88: 3837-3845
38. 38. Hemmer CJ, Bierhaus A, v. Riedesel J et al. (1994): Elevated thrombomodulin plasma levels as a result of endothelial involvement in plasmodium falciparum malaria. Thromb Haemost 72: 457-464
39. 39. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgramm quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72: 248-254
40. 40. Pahl HL, Baeuerle PA (1995) Expression of influenza virus hemagglutinin activates the transcription factor NFkB. J Virol 69: 1480-1484
41. 41. Bierhaus A, Zhang Y, Deng Y et al. (1995) Mechanism of the TNFα mediated induction of endothelial tissue factor. J Biol Chem 270: 26419-26432
42. 42. Bierhaus A, Zhang Y, Quehenberger P et al. (1997) The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-κB. Thromb Haemost 77: 772-782
43. 43. Melton DA, Krieg PA, Rabdaliati MR, Maniatis T, Zinn K, Green MR (1984) Efficient synthesis of biologically active RNA and RNA hybridisation probes from plasmids containing a bacteriophage SP6 promotor. Nucleic Acids Res 12: 7035-7056
44. 44. Janero DR (1990) Malonaldehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 9: 515-540
45. 45. Sernau T, Wilhelm O, Seyfert U et al. (1995) Thrombomodulin ist ein Marker für mikrovaskuläre, aber nicht für makrovaskuläre Endothelschädigung. Vasa 24: 347-353
46. 46. Rinno H, Kuramoto T, Iijima T, Yagame M, Tomino Y (1996) Measurement of soluble thrombomodulin in sera from various clinical stages of diabetic nephropathy. J Clin Lab Anal 10: 119-124
47. 47. Hofmann MA, Kohl B, Zumbach MS et al. (1997) Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM. Diabetes Care 20: 1880-1887
48. 48. Yaqoob M, Patrick AW, McClelland P et al. (1993) Relationsship between markers of endothelial dysfunction, oxidant injury and tubular damage in patients with insulin-dependent diabetes mellitus. Clin Sci (Colch) 85: 557-562
49. 49. The Diabetes Control and Complication Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin dependent diabetes mellitus. N Engl J Med 329: 977-986
50. 50. Vlassara H (1997) Pathogenesis of diabetic nephropathy, advanced glycation and new therapy. Med Klin 92 [Suppl 1]:29-34
51. 51. Vlassara H (1996) Protein glycation in the kidney: Role in diabetes and aging. Kidney Int 49: 1795-1804
52. 52. Saito T (1997) Abnormal lipid metabolism and renal disorder. Tohoku J Exp Med 181: 321-337
53. 53. Biesenbach G, Janko O, Zazgornik J (1994) Similar rate of progression in the predialysis phase in type I and type II diabetes mellitus. Nephrol Dial Transplant 9: 1097-1102
54. 54. Schmidt AM, Crandall J, Hori O, Cao R, Lakatta E (1996) Elevated plasma levels of vascular cell adhesion molecule-1 (VCAM-1) in diabetic patients with microalbuminuria: a marker of vascular dysfunction and progressive vascular disease. Br J Haematol 92: 747-750
55. 55. Zumbach M, Hofmann M, Borcea V et al. (1997) Tissue Factor antigen is elevated in patients with microvascular complications of diabetes mellitus. Exp Clin Endocrinol Diabetes 105: 206-212
56. 56. Bazzan M, Gruden G, Stella S et al. (1998) Microalbuminuria in IDDM is associated with increased expression of monocyte procoagulant activity. Diabetologia 41: 767-771
57. 57. Utsunomiya K, Ohta H, Kurata H, Tajima N, Isogai Y (1995) The effect of macrophage colony-stimulating factor (M-CSF) on the progression of lipid-induced nephrotoxicity in diabetic nephropathy. J Diabetes Complications 9: 292-295
58. 58. Beg AA, Sha WT, Bronson RT, Ghosh S, Baltimore D (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376: 167-170
59. 59. Baichwal VR, Baeuerle PA (1997) Apoptosis: Activate NF-κB or die? Current Biology 7: R94-R96