Mechanism of action of the non-steroidal anti-inflammatory drug flufenamate on [Ca2+]i and Ca2+-activated currents in neurons

Cell Calcium

Volumn 19, Issue 5, 1996, Pages 431-438

  Lee, Rebecca J ^a   Shaw, Travis ^a   Sandquist, Michael ^a   Partridge, L Donald ^a,b  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; FLUFENAMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; CALCIUM ION; THAPSIGARGIN;

ANIMAL; ARTICLE; CELL CULTURE; ION TRANSPORT; METABOLISM; NERVE CELL; ANALGESIA; ANIMAL CELL; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; EXTRACELLULAR CALCIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALCIUM; CELLS, CULTURED; FLUFENAMIC ACID; ION TRANSPORT; NEURONS;

ANIMALIA;

EID: 0029665561     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0143-4160(96)90116-5     Document Type: Article

References (36)

1. 2+-activated channels in neurons. Neurosci Lett 1995; 190: 121-124.
2. Kostyuk P.G. Calcium Ions in Nerve Cell Function. Oxford: Oxford University Press, 1992.
3. Pozzan T., Rizzuto R., Volpe P., Meldolesi J. Molecular and cellular physiology of intracellular calcium stores. Physiol Rev 1994; 74: 595-636.
4. 2+ transients in isolated snail neurons. Neuroscience 1993; 53: 943-947.
5. Kostyuk P.G., Verkhratsky A.N. Calcium Signalling in the Nervous System. Chichester: Wiley, 1995.
6. Kao L.S., Knox R.J., Jonas E.A., Connor J.A., Kaczmarck L.K. Thapsigargin activates an inward current and specifically increases intracellular calcium at the soma of bag cell neurons in culture. Neurosci Abs 1992; 243.5
7. 2+-ATPase family of calcium pumps. J Biol Chem 1991; 266: 17067-17071.
8. 2+-ATPases. Proc Natl Acad Sci USA 1990; 87: 2466-2470.
9. Hidaka H., Inagaki M., Kawamoto S., Sasaki Y. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 1984; 23: 5036-5041.
10. Grynkiewicz G., Poenie M., Tsien R.Y. A new generation of fluorescent calcium indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440-3450.
11. Owen C.S. Spectra of intracellular Fura-2. Cell Calcium 1991; 12: 385-393.
12. Partridge L.D., Swandulla D., Müller T.H. Modulation of calcium-activated non-specific cation currents by cyclic AMP-dependent phosphorylation in neurons of Helix. J Physiol 1990; 429: 131-145.
13. Kano M., Garaschuk O., Verkhratsky A., Konnerth A. Ryanodine receptor-mediated intracellular calcium release in rat cerebellar Purkinje neurons. J Physiol 1995; 487: 1-16.
14. 2+ activity regulation as measured by a calcium-activated current. Brain Res 1994; 647: 76-82.
15. Nelson E.J., Li C.C., Bangalore R., Benson T., Kass R.S., Hinkle P.M. Inhibition of L-type calcium-channel activity by thapsigargin and 2,5-t-butylhydroquinone, but not by cyclopiazonic acid. Biochem J 1994; 302: 147-154.
16. 2+channels. Neuroscience 1995; 65: 1109-1118.
17. Blaustein M.P. Calcium transport and buffering in neurons. Trends Neurosci 1988; 11: 438-443.
18. McDougall P., Markham A., Cameron I., Sweetman A.J. Action of the nonsteroidal anti-inflammatory agent, flufenamic acid, on calcium movements in isolated mitochondria. Biochem Pharmacol 1988; 37: 1327-1330.
19. Flutney J.W. A model for receptor-regulated calcium entry. Cell Calcium 1986; 7: 1-12.
20. Takemura H., Hughes A.R., Thastrup O., Putney Jr J.W. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. J Biol Chem 1989; 264: 266-271.
21. Hoth M., Penner R. Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 1992; 355: 353-356.
22. 2+ release by flufenamic acid and other blockers of the non-selective cation channel. FEBS Lett 1992; 296: 245-248.
23. - channel blocker in human endothelial cells. Eur J Pharmacol 1994; 269: 381-384.
24. Gögelein H. Dahlem D., Englert H.C., Lang H.J. Flufenamic acid, mefenamic acid, and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas. FEBS Lett 1990; 268: 79-82.
25. Jung F., Selvaraj S., Gargus JJ. Blockers of platelet-derived growth factor-activated nonselective cation channels inhibit cell proliferation. Am J Physiol 1992; 262: C1464-C1470.
26. Popp R., Gögelein H. A calcium and ATP sensitive nonselective cation channel in the antiluminal membrane of rat cerebral capillary endothelial cells. Biochim Biophys Acta 1992; 1108: 59-66.
27. Siemer C., Gögelein H. Activation of nonselective cation channels in the basolateral membrane of rat distal colon crypt cells by prostaglandin E2. Pflügers Arch 1992; 420: 319-328.
28. - channel by two closely related arylaminobenzoates. J Gen Physiol 1993; 102: 1-23.
29. 2+ injection into Helix neurons. Nature 1981; 293: 158-159.
30. 2+-activated channels in bursting neurons of Helix. Pflügers Arch 1987; 410: 627-631.
31. Razani-Boroujerdi S., Partridge L. D. Activation and modulation of calcium-activated non-selective cation channels from embryonic chick sensory neurons. Brain Res 1993; 623: 195-200.
32. Levy S. Effect of intracellular injection of inositol trisphosphate on cytosolic calcium and membrane currents in Aplysia neurons. J Neurosci 1992; 12: 2120-2129.
33. Bannwarth B., Demotes-Mainard F., Schaeverbeke T., Labat L., Dehais J. Central analgesic effects of aspirin-like drugs. Fundam Clin Pharmacol 1995; 9: 1-7.
34. Bjorkmann R. Central anti-nociceptive effects of non-steroidal antiinflammatory drugs and paracetamol: experimental studies in the rat. Acta Anaesthesiol Scan Suppl 1995; 103: 1-44.
35. McCormack K. The spinal actions of non-steroidal anti-inflammatory drugs and the dissociation between their anti-inflammatory and analgesic effects. Drugs 1994; 47 (Suppl. 5): 28-45.
36. McCormack K. Non-steroidal anti-inflammatory drugs and spinal nociceptive processing. Pain 1994; 49: 9-43.