Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C. Use of engineered disulfide bridges, antibodies, and carboxymethylpapain to stabilize the monomeric form of cystatin C

Journal of Biological Chemistry

Volumn 279, Issue 23, 2004, Pages 24236-24245

  Nilsson, Maria ^a   Wang, Xin ^a   Rodziewicz Motowidlo, Sylwia ^c   Janowski, Robert ^e   Lindström, Veronica ^a   Önnerfjord, Patrik ^b   Westermark, Gunilla ^d   Grzonka, Zbigniew ^c   Jaskolski, Mariusz ^e   Grubb, Anders ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF GDA SK   (Poland)

^d LINKÖPING UNIVERSITY   (Sweden)

^e ADAM MICKIEWICZ UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; DIMERIZATION; ENZYME INHIBITION; ENZYMES;

BIOLOGICAL FUNCTIONS; DOMAIN SWAPPING;

BIOCHEMISTRY;

AMYLOID; CARBOXYMETHYLPAPAIN; CYSTATIN C; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; DISULFIDE; MONOCLONAL ANTIBODY; PAPAIN; UNCLASSIFIED DRUG;

AMYLOIDOSIS; ARTICLE; BRAIN HEMORRHAGE; CATALYSIS; CONTROLLED STUDY; DIMERIZATION; ENZYME INACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN STABILITY;

AMYLOID; ANTIBODIES, MONOCLONAL; CYSTATINS; DIMERIZATION; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; ESCHERICHIA COLI; HUMANS; KINETICS; MASS SPECTROMETRY; MICROSCOPY, ELECTRON; MUTAGENESIS, SITE-DIRECTED; PAPAIN; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS; TRYPSIN;

EID: 2642567686     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M402621200     Document Type: Article

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