Coexpression of GSK-3β corrects phenotypic aberrations of dorsal root ganglion cells, cultured from adult transgenic mice overexpressing human protein tau

Neurobiology of Disease

Volumn 9, Issue 1, 2002, Pages 38-48

  Nuydens, R ^a   Van Den Kieboom, G ^a   Nolten, C ^a   Verhulst, C ^a   Van Osta, P ^a   Spittaels, K ^b   Van den Haute, C ^b   De Feyter, E ^a   Geerts, H ^a   Van Leuven, F ^b  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Axonal transport; Dorsal root ganglion neuron; GSK 3 ; Microtubules; Tau; Transgenics

Indexed keywords

GENE PRODUCT; PROTEIN GSK 3BETA; TAU PROTEIN; UNCLASSIFIED DRUG; GLYCOGEN SYNTHASE KINASE 3; PROTEIN KINASE (CALCIUM,CALMODULIN); TUBULIN;

ANIMAL TISSUE; ARTICLE; CELL DENSITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOSKELETON; GENE OVEREXPRESSION; MICROTUBULE; MOUSE; NERVE CELL CULTURE; NERVE FIBER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SPINAL GANGLION; TRANSGENIC MOUSE; ACETYLATION; AGE; ANIMAL; CELL CULTURE; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; NERVE CELL; NERVE FIBER TRANSPORT; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

ACETYLATION; AGE FACTORS; ANIMALS; AXONAL TRANSPORT; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; GANGLIA, SPINAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICE; MICE, TRANSGENIC; MICROTUBULES; NEURONS; PHENOTYPE; PHOSPHORYLATION; TAU PROTEINS; TUBULIN;

EID: 0036008557     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2001.0454     Document Type: Article

References (41)

1. Neural and developmental actions of lithium: A unifying hypothesis
2. Regulated phosphorylation and dephosphorylation of tau protein: Effects on microtubule interaction, intracellular trafficking and neurodegeneration
3. Composite microtubules of the axon: Quantitative analysis of tyrosinated and acetylated tubulin along individual axonal microtubules
4. Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3b S9A
5. Overexpression of growth-associated proteins in the neurons of adult transgenic mice
6. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons
7. Organelle transport and sorting in axons
8. Specificity and mechanisms of action of some commonly used protein kinase inhibitors
9. Purification and culture of adult rat dorsal root ganglion neurons
10. Overexpression of tau protein inhibits kinesin dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: Implications for Alzheimer's disease
11. Color and geometrical structure in images
12. Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: Identification of phosphorylation sites in tau protein
13. Microtubule based transport systems in neurons: The roles of kinesins and dyneins
14. Domains of tau protein and interactions with microtubules
15. Competition between motor molecules (kinesin and cytoplasmic dynein) and fibrous microtubule-associated proteins in binding to microtubules
16. Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3
17. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
18. A molecular mechanism for the effect of lithium on development
19. Overexpression of tau in a nonneuronal cell induces long cellular processes
20. The function of the microtubule associated protein tau is variably modulated by graded changes in glycogen synthase kinase-3b S9A
21. Phosphorylation of tau by glycogen synthase kinase-3b S9A in intact mammalian cells: The effects on the organization and stability of microtubules
22. Lithium at 50: Have the neuroprotective effects of this unique cation been overlooked?
23. Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes
24. Lithium inhibits Alzheimer's disease-like phosphorylation in neurons
25. The fast axonal transport in hippocampal neurones is acutely enhanced by dB-cAMP
26. The "jaws" model of tau-microtubule interaction examined in CHO cells
27. Structural interaction of cytoskeletal elements
28. Glycogen synthase kinase-3b S9A phosphorylates tau and rescues the axonopathy in the central nervous syslates tem of human four-repeat tau transgenic mice
29. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein
30. Microtubule-associated proteins regulate microtubule function as the track for intracellular membrane organelle transports
31. Motor and cargo interactions
32. Lithium inhibits glycogen synthase kinase-3b S9A activity and mimics wingless signalling in intact cells
33. An unbiased detector of curvilinear structures
34. Taxol impairs anterograde axonal transport of microinjected horseradish peroxidase in dorsal root ganglion neurons in vitro
35. Dynamics of tau protein, differential phosphorylation and dynamic instability of microtubules
36. Tau regulates the attachment/deattachment but not the speed of motors in microtubule-dependent transport of single vesicles
37. Lithium activates the c-Jun NH2-terminal kinases in vitro and in the CNS in vivo
38. Tau is phosphorylated by GSK-3 at several sites found in Alzheimer's disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase