-
2
-
-
0003844786
-
-
Institute of Medicine of the National Academies, Washington, DC
-
Institute of Medicine 2000 Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline [online]. Institute of Medicine of the National Academies, Washington, DC. http://www.iom.edu/report.asp?id=8524 [accessed February 23, 2004].
-
(2000)
Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline [Online]
-
-
-
6
-
-
0042088455
-
-
Food Standards Agency
-
Expert Group on Vitamins and Minerals (2003) Safe Upper Levels for Vitamins and Minerals [online]. Food Standards Agency, http://www.foodstandards.gov.uk/multimedia/pdfs/vitmin2003.pdf [accessed March 28, 2004].
-
(2003)
Safe Upper Levels for Vitamins and Minerals [Online]
-
-
-
7
-
-
1842666616
-
Risk characterization of chemicals in food
-
Renwick, A. G. (2004) Risk characterization of chemicals in food. Toxicol. Lett. 149: 163-176.
-
(2004)
Toxicol. Lett.
, vol.149
, pp. 163-176
-
-
Renwick, A.G.1
-
8
-
-
0141922881
-
Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements
-
Schilter, B., Andersson, C., Anton, R., Constable, A., Kleiner, J., O'Brien, J., Renwick, A. G., Korver, O., Smit, F. & Walker, R. (2003) Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements. Food Chem. Toxocol. 41: 1625-1649.
-
(2003)
Food Chem. Toxocol.
, vol.41
, pp. 1625-1649
-
-
Schilter, B.1
Andersson, C.2
Anton, R.3
Constable, A.4
Kleiner, J.5
O'Brien, J.6
Renwick, A.G.7
Korver, O.8
Smit, F.9
Walker, R.10
-
9
-
-
0028350811
-
A critical review of the optimum duration of chronic rodent testing for the determination of non-tumourigenic toxic potential: A report by the BTS Working Party on Duration of Toxicity Testing
-
Betton, G., Cockburn, A., Harpur, E., Hopkins, J., Illing, P., Lumley, C. & Connors, T. (1994) A critical review of the optimum duration of chronic rodent testing for the determination of non-tumourigenic toxic potential: a report by the BTS Working Party on Duration of Toxicity Testing. Hum. Exp. Toxicol. 13: 221-232.
-
(1994)
Hum. Exp. Toxicol.
, vol.13
, pp. 221-232
-
-
Betton, G.1
Cockburn, A.2
Harpur, E.3
Hopkins, J.4
Illing, P.5
Lumley, C.6
Connors, T.7
-
10
-
-
0033037422
-
The duration of non-rodent toxicity studies for pharmaceuticals. International Conference on Harmonisation (ICH)
-
DeGeorge, J. J., Meyers, L. L., Takahashi, M. & Contrera, J. F. (1999) The duration of non-rodent toxicity studies for pharmaceuticals. International Conference on Harmonisation (ICH). Toxicol. Sci. 49: 143-155.
-
(1999)
Toxicol. Sci.
, vol.49
, pp. 143-155
-
-
DeGeorge, J.J.1
Meyers, L.L.2
Takahashi, M.3
Contrera, J.F.4
-
11
-
-
0033934754
-
The industry view on long-term toxicology testing in drug development of human pharmaceuticals
-
Van Cauteren, H., Bentley, P., Bode, G., Cordier, A., Coussement, W., Heining, P. & Sims, J. (2000) The industry view on long-term toxicology testing in drug development of human pharmaceuticals. Pharmacol. Toxicol. 86 (suppl. 1): 1-5.
-
(2000)
Pharmacol. Toxicol.
, vol.86
, Issue.SUPPL. 1
, pp. 1-5
-
-
Van Cauteren, H.1
Bentley, P.2
Bode, G.3
Cordier, A.4
Coussement, W.5
Heining, P.6
Sims, J.7
-
12
-
-
0020578205
-
Neurochemical changes following high-dose aspartame with dietary carbohydrate
-
Wurtman, R. J. (1983) Neurochemical changes following high-dose aspartame with dietary carbohydrate. N. Engl. J. Med. 390: 429-430.
-
(1983)
N. Engl. J. Med.
, vol.390
, pp. 429-430
-
-
Wurtman, R.J.1
-
13
-
-
0021248304
-
Effects of aspartame and glucose administration on brain and plasma levels of large neutral amino acids and brain 5-hydoxyindoles
-
Yokogoshi, H., Roberts, H. C., Caballero, B. & Wurtman, R. J. (1984) Effects of aspartame and glucose administration on brain and plasma levels of large neutral amino acids and brain 5-hydoxyindoles. Am. J. Clin. Nutr. 40: 1-7.
-
(1984)
Am. J. Clin. Nutr.
, vol.40
, pp. 1-7
-
-
Yokogoshi, H.1
Roberts, H.C.2
Caballero, B.3
Wurtman, R.J.4
-
14
-
-
0022524837
-
Effects of aspartame ingestion on the carbohydrate-induced rise in tryptophan hydroxylation rate in rat brain
-
Fernstrom, J. D., Fernstrom, M. H. & Grubb, P. E. (1986) Effects of aspartame ingestion on the carbohydrate-induced rise in tryptophan hydroxylation rate in rat brain. Am. J. Clin. Nutr. 44: 195-205.
-
(1986)
Am. J. Clin. Nutr.
, vol.44
, pp. 195-205
-
-
Fernstrom, J.D.1
Fernstrom, M.H.2
Grubb, P.E.3
-
15
-
-
0022618206
-
Neurochemical alterations induced by the artificial sweetener aspartame (Nutrasweet)
-
Coulombe, R. A. & Sharma, R. P. (1986) Neurochemical alterations induced by the artificial sweetener aspartame (Nutrasweet). Toxicol. Appl. Pharmacol. 83: 79-85.
-
(1986)
Toxicol. Appl. Pharmacol.
, vol.83
, pp. 79-85
-
-
Coulombe, R.A.1
Sharma, R.P.2
-
16
-
-
0024241222
-
Aspartame and the rat brain monoaminergic system
-
Perego, C., De Simoni, M. G., Fodritto, F., Raimondi, L., Diomede, L., Salmona, M., Algeri, S. & Garattini, S. (1988) Aspartame and the rat brain monoaminergic system. Toxicol. Lett. 44: 331-339.
-
(1988)
Toxicol. Lett.
, vol.44
, pp. 331-339
-
-
Perego, C.1
De Simoni, M.G.2
Fodritto, F.3
Raimondi, L.4
Diomede, L.5
Salmona, M.6
Algeri, S.7
Garattini, S.8
-
17
-
-
0025284644
-
Plasma and brain kinetics of large neutral amino acids and of striatum monoamines in rats given aspartame
-
Romano, M., Diomede, L., Guiso, G., Caccia, S., Perego, C. & Salmona, M. (1990) Plasma and brain kinetics of large neutral amino acids and of striatum monoamines in rats given aspartame. Food Chem. Toxicol. 28: 317-321.
-
(1990)
Food Chem. Toxicol.
, vol.28
, pp. 317-321
-
-
Romano, M.1
Diomede, L.2
Guiso, G.3
Caccia, S.4
Perego, C.5
Salmona, M.6
-
18
-
-
0024786855
-
Chronic aspartame ingestion does not alter cerebral levels of aminergic neurotransmitters and related amino acids in the rat brain
-
Reilly, M. A., Debler, E. A., Fleisher, A. & Lajtha, A. (1989) Chronic aspartame ingestion does not alter cerebral levels of aminergic neurotransmitters and related amino acids in the rat brain. Res. Commun, Psychol. Psychiatry Behav. 14: 287-303.
-
(1989)
Res. Commun., Psychol. Psychiatry Behav.
, vol.14
, pp. 287-303
-
-
Reilly, M.A.1
Debler, E.A.2
Fleisher, A.3
Lajtha, A.4
-
19
-
-
2642584429
-
Reply to letter by Wurtman
-
Fernstrom, J. D. (1987) Reply to letter by Wurtman. Am. J. Clin. Nutr. 45: 801-803.
-
(1987)
Am. J. Clin. Nutr.
, vol.45
, pp. 801-803
-
-
Fernstrom, J.D.1
-
20
-
-
0023316530
-
Aspartame effects on brain serotonin
-
Wurtman, R. J. (1987) Aspartame effects on brain serotonin. Am. J. Clin. Nutr. 45: 799-801.
-
(1987)
Am. J. Clin. Nutr.
, vol.45
, pp. 799-801
-
-
Wurtman, R.J.1
-
21
-
-
0023281032
-
Effects of oral aspartame on plasma phenylalanine in humans and experimental rodents
-
Wurtman, R. J. & Maher, T. J. (1987) Effects of oral aspartame on plasma phenylalanine in humans and experimental rodents. J. Neural Transm. 70: 169-173.
-
(1987)
J. Neural Transm.
, vol.70
, pp. 169-173
-
-
Wurtman, R.J.1
Maher, T.J.2
-
22
-
-
0024595813
-
Oral aspartame and plasma phenylalanine: Pharmacokinetic difference between rodents and man, and relevance to CNS effects of phenylalanine
-
Femstrom, J. D. (1989) Oral aspartame and plasma phenylalanine: pharmacokinetic difference between rodents and man, and relevance to CNS effects of phenylalanine. J. Neural Transm. 75: 159-164.
-
(1989)
J. Neural Transm.
, vol.75
, pp. 159-164
-
-
Femstrom, J.D.1
-
23
-
-
0024538553
-
Effects of aspartame and carbohydrate administration on human and rat plasma large neutral amino acid levels and rat brain amino acid and monoamine levels
-
Romano, M., Casacci, F., De Marchi, F., Pacei, T., Esteve, A., Lomuscio, G., Mennini, T. & Salmona, M. (1989) Effects of aspartame and carbohydrate administration on human and rat plasma large neutral amino acid levels and rat brain amino acid and monoamine levels. J. Nutr. 119: 75-81.
-
(1989)
J. Nutr.
, vol.119
, pp. 75-81
-
-
Romano, M.1
Casacci, F.2
De Marchi, F.3
Pacei, T.4
Esteve, A.5
Lomuscio, G.6
Mennini, T.7
Salmona, M.8
-
24
-
-
18744379772
-
Aspartame: Review of safety
-
Butchko, H. H., Stargel, W. W., Comer, C. P., Mayhew, D. A., Benninger, C., Blackburn, G. L., de Sonneville, L.M.J., Geha, R. S., Hertelendy, Z., et al. (2002) Aspartame: review of safety. Regul. Toxicol. Pharmacol. 35: S1-S93.
-
(2002)
Regul. Toxicol. Pharmacol.
, vol.35
-
-
Butchko, H.H.1
Stargel, W.W.2
Comer, C.P.3
Mayhew, D.A.4
Benninger, C.5
Blackburn, G.L.6
De Sonneville, L.M.J.7
Geha, R.S.8
Hertelendy, Z.9
-
25
-
-
0037712811
-
Amino acid pharmacokinetics and safety assessment
-
Bier, D. M. (2003) Amino acid pharmacokinetics and safety assessment. J. Nutr, 133 (suppl. 1): 2034S-2039S.
-
(2003)
J. Nutr.
, vol.133
, Issue.SUPPL. 1
-
-
Bier, D.M.1
-
26
-
-
0036119438
-
Mathematical modelling and quantitative methods
-
Edier, L., Poirier, K., Dourson, M., Kleiner, J., Mileson, B., Nordmann, H., Renwick, A., Slob, W., Walton, K, & Würtzen, G. (2002) Mathematical modelling and quantitative methods. Food Chem. Toxicol. 40: 283-326.
-
(2002)
Food Chem. Toxicol.
, vol.40
, pp. 283-326
-
-
Edier, L.1
Poirier, K.2
Dourson, M.3
Kleiner, J.4
Mileson, B.5
Nordmann, H.6
Renwick, A.7
Slob, W.8
Walton, K.9
Würtzen, G.10
-
27
-
-
0038388932
-
The safety testing of amino acids
-
Renwick, A. G. (2003) The safety testing of amino acids. J. Nutr. 133 (suppl. 1): 2031S-2033S.
-
(2003)
J. Nutr.
, vol.133
, Issue.SUPPL. 1
-
-
Renwick, A.G.1
-
28
-
-
0027171701
-
Data-derived safety factors for the evaluation of food additives and environmental contaminants
-
Renwick, A. G. (1993) Data-derived safety factors for the evaluation of food additives and environmental contaminants. Food Addit. Contam. 10: 275-305.
-
(1993)
Food Addit. Contam.
, vol.10
, pp. 275-305
-
-
Renwick, A.G.1
-
30
-
-
0038727146
-
Approaches to risk assessment for macronutrients and amino acids
-
Roddcks, J. V. (2003) Approaches to risk assessment for macronutrients and amino acids. J. Nutr. 133 (suppl. 1): 2025S-2030S.
-
(2003)
J. Nutr.
, vol.133
, Issue.SUPPL. 1
-
-
Roddcks, J.V.1
-
32
-
-
0035977869
-
The use of surrogate endpoints to assess potential toxicity in humans
-
Renwick, A, G. & Walton, K. (2001) The use of surrogate endpoints to assess potential toxicity in humans. Toxicol. Lett. 120: 97-110.
-
(2001)
Toxicol. Lett.
, vol.120
, pp. 97-110
-
-
Renwick, A.G.1
Walton, K.2
-
33
-
-
0027255382
-
A comparative study on the synthesis of dopamine in the human, dog and rat kidney
-
Soares-da-Silva, P., Fernandes, M. H. & Pestana, M. (1993) A comparative study on the synthesis of dopamine in the human, dog and rat kidney. Acta Physiol. Scand. 148: 347-351.
-
(1993)
Acta Physiol. Scand.
, vol.148
, pp. 347-351
-
-
Soares-da-Silva, P.1
Fernandes, M.H.2
Pestana, M.3
-
34
-
-
0022967066
-
Plasma free amino acid values in normal children and adolescents
-
Gregory, D. M., Sovetts, D., Clow, C. L. & Scriver, C. R. (1986) Plasma free amino acid values in normal children and adolescents. Metabolism 35: 967-969.
-
(1986)
Metabolism
, vol.35
, pp. 967-969
-
-
Gregory, D.M.1
Sovetts, D.2
Clow, C.L.3
Scriver, C.R.4
-
35
-
-
0021238970
-
Diurnal variations in plasma concentrations of basic and neutral amino acids and in red cell concentrations of aspartate and glutamate: Effects of dietary protein intake
-
Maher, T. J., Glaeser, B. S. & Wurtman, R. J. (1984) Diurnal variations in plasma concentrations of basic and neutral amino acids and in red cell concentrations of aspartate and glutamate: effects of dietary protein intake. Am. J. Clin. Nutr. 39: 722-729.
-
(1984)
Am. J. Clin. Nutr.
, vol.39
, pp. 722-729
-
-
Maher, T.J.1
Glaeser, B.S.2
Wurtman, R.J.3
-
36
-
-
0038671678
-
Postprandial kinetics of dietary amino acids are the main determinant of their metabolism after soy or milk protein ingestion in humans
-
Bos, C., Metges, C. C., Gaudichon, C., Petzke, K. J., Pueyo, M. E., Morens, C., Everwand, J., Benamouzig, R. & Tome, D. (2003) Postprandial kinetics of dietary amino acids are the main determinant of their metabolism after soy or milk protein ingestion in humans. J. Nutr. 133: 1308-1315.
-
(2003)
J. Nutr.
, vol.133
, pp. 1308-1315
-
-
Bos, C.1
Metges, C.C.2
Gaudichon, C.3
Petzke, K.J.4
Pueyo, M.E.5
Morens, C.6
Everwand, J.7
Benamouzig, R.8
Tome, D.9
-
37
-
-
0027163587
-
Kinetics of plasma homocysteine in healthy subjects after peroral homocysteine loading
-
Guttormsen, A. B., Mansoor, A. M., Fiskerstrand, T., Ueland, P. M. & Refsum, H. (1993) Kinetics of plasma homocysteine in healthy subjects after peroral homocysteine loading. Clin. Chem. 39: 1390-1397.
-
(1993)
Clin. Chem.
, vol.39
, pp. 1390-1397
-
-
Guttormsen, A.B.1
Mansoor, A.M.2
Fiskerstrand, T.3
Ueland, P.M.4
Refsum, H.5
-
38
-
-
0031809917
-
Human variability and noncancer risk assessment-an analysis of the default uncertainty factor
-
Renwick, A. G. & Lazarus, N. R. (1998) Human variability and noncancer risk assessment-an analysis of the default uncertainty factor. Regul. Toxicol. Pharmacol. 27: 3-20.
-
(1998)
Regul. Toxicol. Pharmacol.
, vol.27
, pp. 3-20
-
-
Renwick, A.G.1
Lazarus, N.R.2
-
39
-
-
0025128021
-
Excretion of 3-mercaptolactate-cysteine mixed disulfide, sulfate and taurine in human urine before and after oral administration of sulfur-containing amino acids
-
Yuasa, S., Akagi, R., Ubuka, T., Masuoka, N. & Yao, K. (1990) Excretion of 3-mercaptolactate-cysteine mixed disulfide, sulfate and taurine in human urine before and after oral administration of sulfur-containing amino acids. Acta Med. Okayama 44: 117-122.
-
(1990)
Acta Med. Okayama
, vol.44
, pp. 117-122
-
-
Yuasa, S.1
Akagi, R.2
Ubuka, T.3
Masuoka, N.4
Yao, K.5
-
40
-
-
0034993738
-
Uncertainty factors for chemical risk assessment: Interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates
-
Dorne, J.L.C.M., Walton, K. & Renwick, A. G. (2001) Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates. Food Chem. Toxicol. 39: 681-696.
-
(2001)
Food Chem. Toxicol.
, vol.39
, pp. 681-696
-
-
Dorne, J.L.C.M.1
Walton, K.2
Renwick, A.G.3
-
41
-
-
0034756279
-
Human variability in glucuronidation in relation to uncertainty factors for risk assessment
-
Dorne, J.L.C.M., Walton, K. & Renwick, A. G. (2001) Human variability in glucuronidation in relation to uncertainty factors for risk assessment. Food. Chem. Toxicol. 39: 1153-1173.
-
(2001)
Food Chem. Toxicol.
, vol.39
, pp. 1153-1173
-
-
Dorne, J.L.C.M.1
Walton, K.2
Renwick, A.G.3
-
42
-
-
0036046179
-
Human variability in polymorphic CYP2D6 metabolism: Is the kinetic default uncertainty factor adequate?
-
Dome, J.L.C.M., Walton, K., Slob, W. & Renwick, A. G. (2002) Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate? Food Chem. Toxicol. 40: 1633-1656.
-
(2002)
Food Chem. Toxicol.
, vol.40
, pp. 1633-1656
-
-
Dome, J.L.C.M.1
Walton, K.2
Slob, W.3
Renwick, A.G.4
-
43
-
-
0037290646
-
Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors
-
Dome, J.L.C.M., Walton, K. & Renwick, A. G. (2003) Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors. Food Chem. Toxicol. 41: 201-224.
-
(2003)
Food Chem. Toxicol.
, vol.41
, pp. 201-224
-
-
Dome, J.L.C.M.1
Walton, K.2
Renwick, A.G.3
-
44
-
-
0037290590
-
Polymorphic CYP2C19 and N-acetylation: Human variability in kinetics and pathway-related uncertainty factors
-
Dome, J.L.C.M., Walton, K. & Renwick, A. G. (2003) Polymorphic CYP2C19 and N-acetylation: human variability in kinetics and pathway-related uncertainty factors. Food Chem. Toxicol. 41: 225-245.
-
(2003)
Food Chem. Toxicol.
, vol.41
, pp. 225-245
-
-
Dome, J.L.C.M.1
Walton, K.2
Renwick, A.G.3
-
45
-
-
0345528143
-
Human variability in the renal elimination of foreign compounds and renal excretion-related uncertainty factors for risk assessment
-
Dome, J.L.C.M., Walton, K. & Renwick, A. G. (2003) Human variability in the renal elimination of foreign compounds and renal excretion-related uncertainty factors for risk assessment. Food Chem. Toxicol. 42: 281-304.
-
(2003)
Food Chem. Toxicol.
, vol.42
, pp. 281-304
-
-
Dome, J.L.C.M.1
Walton, K.2
Renwick, A.G.3
-
46
-
-
1042290482
-
Human variability for metabolic pathways with limited data (CYP2A6, CYP2C9, CYP2E1, ADH, esterases, glycine and sulphate conjugation)
-
Dome, J.L.C.M., Walton, K. & Renwick, A. G. (2003) Human variability for metabolic pathways with limited data (CYP2A6, CYP2C9, CYP2E1, ADH, esterases, glycine and sulphate conjugation). Food Chem. Toxicol. 42: 397-421.
-
(2003)
Food Chem. Toxicol.
, vol.42
, pp. 397-421
-
-
Dome, J.L.C.M.1
Walton, K.2
Renwick, A.G.3
-
50
-
-
0041379637
-
Risk characterization of chemicals in food and diet
-
Renwick, A. G., Barlow, S. M., Hertz-Picciotto, I., Boobis, A. R., Dybing, E., Edler, L., Eisenbrand, G., Greig, J. B., Kleiner, J., et al. (2003) Risk characterization of chemicals in food and diet. Food Chem. Toxicol. 41: 1211-1271.
-
(2003)
Food Chem. Toxicol.
, vol.41
, pp. 1211-1271
-
-
Renwick, A.G.1
Barlow, S.M.2
Hertz-Picciotto, I.3
Boobis, A.R.4
Dybing, E.5
Edler, L.6
Eisenbrand, G.7
Greig, J.B.8
Kleiner, J.9
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