The safety testing of amino acids

Journal of Nutrition

Volumn 133, Issue 6 SUPPL. 1, 2003, Pages

  Renwick, Andrew G ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Amino acids; Biomarkers; Metabonomics; Risk assessment; Toxicokinetics

Indexed keywords

AMINO ACID; BIOLOGICAL MARKER;

BLOOD ANALYSIS; CONFERENCE PAPER; DIET SUPPLEMENTATION; FOOD SAFETY; HEALTH HAZARD; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RISK ASSESSMENT; TOXICOKINETICS; URINALYSIS;

ANIMALIA;

EID: 0038388932     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.6.2031s     Document Type: Conference Paper

References (31)

1. Smith, M. (2002) Food safety in Europe (FOSIE): risk assessment of chemicals in food and diet: overall introduction. Food Chem. Toxicol. 40: 141-144.
2. Edler, L., Poirier, K., Dourson, M., Kleiner, J., Mileson, B., Nordmann, H., Renwick, A., Slob, W., Walton, K. & Wurtzen, G. (2002) Mathematical modelling and quantitative methods. Food Chem. Toxicol. 40: 283-326.
3. Renwick, A. G. (1999) Exposure estimation, toxicological requirements and risk assessment. In: International Food Safety Handbook (van der Heijden, K., Younes, M., Fishbein L., Miller S., eds.), pp. 59-94. Marcel Dekker, New York.
4. Eisenbrand, G., Pool-Zobel, B., Baker, V., Balls, M., Blaauboer, B. J., Boobis, A., Carere, A., Kevekordes, S., Lhuguenot, J.-C., Pieters, R. & Kleiner, J. (2002) Methods of in vitro toxicology. Food Chem. Toxicol. 40: 193-236.
5. Barlow, S. M., Grieg, J. B., Bridges, J. W., Carere, A., Carpy, A. J. M., Galli, C. L., Kleiner, J., Knudsen, I., Koëter, H. B. W. M., Levy, L. S., Madsen, C., Mayer, S., Narbonne, J.-F., Pfannkuch, F., Prodanchuk, M. G., Smith, M. R. & Steinberg, P. (2002) Hazard identification by methods of animal-based toxicology. Food Chem. Toxicol. 40:145-191.
6. Dybing, E., Doe, J., Groten, J., Kleiner, J., O'Brien, J., Renwick, A. G., Schlatter, J., Steinberg, P., Tritscher, A., Walker, R. & Younes, M. (2002) Hazard characterisation of chemicals in food and diet: dose response, mechanisms and extrapolation issues. Food Chem. Toxicol. 40: 237-282.
7. Renwick, A. G. & Walton, K. (2001) The use of surrogate endpoints to assess potential toxicity in humans. Toxicol. Lett. 120: 97-110.
8. Renwick, A. G. (2000) Toxicokinetics: Pharmacokinetics in toxicology. In: Principles and Methods of Toxicology (Hayes, A. W., ed.), pp. 137-191. Taylor & Francis, Philadelphia.
9. Anthony, M. L., Gartland, K. P., Beddell, C. R., Lindon, J. C. & Nicholson, J. K. (1994) Studies of the biochemical toxicology of uranyl nitrate in the rat. Arch. Toxicol. 68: 43-53.
10. Holmes, E., Nicholls, A. W., Lindon, J. C., Connor, S. C., Connelly, J. C., Haselden, J. N., Damment, S. J., Spraul, M., Neidig, P. & Nicholson, J. K. (2000) Chemometric models for toxicity classification based on NMR spectra of biofluids. Chem. Res. Toxicol. 13: 471-478.
11. Nicholls, A. W., Holmes, E., Lindon, J. C., Shockcor, J. P., Farrant, R. D., Haselden, J. N., Damment, S. J., Waterfield, C. J. & Nicholson, J. K. (2001) Metabonomic investigations into hydrazine toxicity in the rat. Chem. Res. Toxicol. 14: 975-987.
12. Ghauri, F. Y., McLean, A. E., Beales, D., Wilson, I. D. & Nicholson, J. K. (1993) Induction of 5-oxoprolinuria in the rat following chronic feeding with N-acetyl 4-aminophenol (paracetamol). Biochem. Pharmacol. 46: 953-957.
13. Foxall, P. J., Lenz, E. M., Lindon, J. C., Neild, G. H., Wilson, I. D. & Nicholson, J. K. (1996) Nuclear magnetic resonance and high-performance liquid chromatography-nuclear magnetic resonance studies on the toxicity and metabolism of ifosfamide. Ther. Drug Monit. 18: 498-505.
14. Foxall, P. J., Singer, J. M., Hartley, J. M., Neild, G. H., Lapsley, M., Nicholson, J. K. & Souhami, R. L. (1997) Urinary proton magnetic resonance studies of early ifosfamide-induced nephrotoxicity and encephalopathy. Clin. Cancer Res. 3: 1507-1518.
15. Gartland, K. P., Bonner, F. W. & Nicholson, J. K. (1989) Investigations into the biochemical effects of region-specific nephrotoxins. Mol. Pharmacol. 35: 242-250.
16. Beckwith-Hall, B. M., Nicholson, J. K., Nicholls, A. W., Foxall, P. J., Lindon, J. C., Connor, S. C., Abdi, M., Connelly, J. & Holmes, E. (1998) Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chem. Res. Toxicol. 11: 260-272.
17. Robertson, D. G., Reily, M. D., Sigler, R. E., Wells, D. F., Paterson, D. A. & Braden, T. K. (2000) Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. Toxicol. Sci. 57: 326-337.
18. Waters, N. J., Garrod, S., Farrant, R. D., Haselden, J. N., Connor, S. C., Connelly, J., Lindon, J. C., Holmes, E. & Nicholson, J. K. (2000) High-resolution magic angle spinning (1)H NMR spectroscopy of intact liver and kidney: optimization of sample preparation procedures and biochemical stability of tissue during spectral acquisition. Anal. Biochem. 282: 16-23.
19. Garrod, S., Humpher, E., Connor, S. C., Connelly, J. C., Spraul, M., Nicholson, J. K. & Holmes, E. (2001) High-resolution (1)H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue. Magn. Reson. Med. 45: 781-790.
20. Griffin, J. L., Troke, J., Walker, L. A., Shore, R. F., Lindon, J. C. & Nicholson, J. K. (2000) The biochemical profile of rat testicular tissue as measured by magic angle spinning 1H NMR spectroscopy. FEBS Lett. 486: 225-229.
21. Garrod, S., Humpfer, E., Spraul, M., Connor, S. C., Polley, S., Connelly, J., Lindon, J. C., Nicholson, J. K. & Holmes, E. (1999) High-resolution magic angle spinning 1H NMR spectroscopic studies on intact rat renal cortex and medulla. Magn. Reson. Med. 41: 1108-1118.
22. Gavaghan, C. L., Holmes, E., Lenz, E., Wilson, I. D. & Nicholson, J. K. (2000) An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse. FEBS Lett. 484: 169-174.
23. Holmes, E., Foxall, P. J., Nicholson, J. K., Neild, G. H., Brown, S. M., Beddell, C. R., Sweatman, B. C., Rahr, E., Lindon, J. C. & Spraul, M. (1994) Automatic data reduction and pattern recognition methods for analysis of 1H nuclear magnetic resonance spectra of human urine from normal and pathological states. Anal. Biochem. 220: 284-296.
24. Bollard, M. E., Holmes, E., Lindon, J. C., Mitchell, S. C., Branstetter, D., Zhang, W. & Nicholson, J. K. (2001) Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition. Anal. Biochem. 295: 194-202.
25. Gartland, K. P., Sanins, S. M., Nicholson, J. K., Sweatman, B. C., Beddell, C. R. & Undon, J. C. (1990) Pattern recognition analysis of high resolution 1H NMR spectra of urine. A nonlinear mapping approach to the classification of toxicological data. NMR Biomed. 3: 166-172.
26. Holmes, E., Nicholls, A. W., Lindon, J. C., Ramos, S., Spraul, M., Neidig, P., Connor, S. C., Connelly, J., Damment, S. J., Haselden, J. & Nicholson, J. K. (1998) Development of a model for classification of toxin-induced lesions using 1H NMR spectroscopy of urine combined with pattern recognition. NMR Biomed. 11: 235-244.
27. Kodama, S., Sugiura, M., Nakao, H., Kobayashi, K., Miyoshi, M., Yoshii, K., Komatsu, M. & Sakurai, T. (1991) 1H-NMR studies of urine in propionic acidemia and methylmalonic acidemia. Acta Paediatr. Jpn. 33: 139-145.
28. Burns, S. P. & Iles, R. A. (1993) An investigation of argininosuccinic acid anhydrides in argininosuccinic acid lyase deficiency by 1H-NMR spectroscopy. Clin. Chim. Acta 221: 1-13.
29. Holmes, E., Foxall, P. J., Spraul, M., Farrant, R. D., Nicholson, J. K. & Lindon, J. C. (1997) 750 MHz 1H NMR spectroscopy characterisation of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduda and maple syrup urine disease. J. Pharm. Biomed. Anal. 15:1647-1659.
30. Ghauri, F. Y., Nicholson, J. K., Sweatman, B. C., Wood, J., Beddell, C. R., Lindon, J. C. & Cairns, N. J. (1993) NMR spectroscopy of human post mortem cerebrospinal fluid: distinction of Alzheimer's disease from control using pattern recognition and statistics. NMR Biomed. 6: 163-167.
31. Griffin, J. L., Williams, H. J., Sang, E., Clarke, K., Rae, C. & Nicholson, J. K. (2001) Metabolic profiling of genetic disorders: a multitissue (1)H nuclear magnetic resonance spectroscopic and pattern recognition study into dystrophic tissue. Anal. Biochem. 293: 16-21.