Amelioration by mercaptoethylguanidine of the vascular and energetic failure in haemorrhagic shock in the anesthetised rat

European Journal of Pharmacology

Volumn 338, Issue 1, 1997, Pages 55-65

  Zingarelli, Basilia ^a   Ischiropoulos, Harry ^b   Salzman, Andrew L ^a   Szabó, Csaba ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

6 Keto prostaglandin 1 ; Haemorrhagic shock; Mercaptoalkylguanidine; Nitric oxide (NO); Peroxynitrite

Indexed keywords

1 (2 MERCAPTOETHYL)GUANIDINE; GUANIDINE; GUANIDINE DERIVATIVE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; HEMORRHAGIC SHOCK; MALE; MEAN ARTERIAL PRESSURE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

6-KETOPROSTAGLANDIN F1 ALPHA; ANIMALS; GUANIDINE; ISOTONIC SOLUTIONS; MALE; MODELS, BIOLOGICAL; NITRATES; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR; RESUSCITATION; SHOCK, HEMORRHAGIC; SULFHYDRYL COMPOUNDS;

EID: 0030689044     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01325-3     Document Type: Article

References (44)

1. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: Implication for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA. 87:1990;1620-1624.
2. Brown I.P., Williams R.L., Mckirnan M.D., Limjoco U.R., Gray C.G. Nitric oxide synthesis inhibition does not improve the hemodynamic response to haemorrhagic shock in dehydrated conscious swine. Shock. 3:1995;292-298.
3. Colasanti M., Persichini T., Menegazzi M., Mariotto S., Giordano E., Caldarera C.M., Sogos V., Lauro G.M., Suzuki H. Induction of nitric oxide synthase mRNA expression. Suppression by exogenous nitric oxide. J. Biol. Chem. 270:1995;26731-26733.
4. Crow J.P., Beckman J.S. The role of peroxynitrite in nitric oxide-mediated toxicity. Curr. Top. Microbiol. Immunol. 196:1995;57-73.
5. Garvey E.P., Oplinger J.A., Tanoury G.J., Sherman P.A., Fowler M., Marshall S., Harmon M.F., Paith J.E., Furfine E.S. Potent and selective inhibition of human nitric oxide synthases. J. Biol. Chem. 269:1994;26669-26676.
6. Hamano K., Tsuboi H., Seyama A., Esato K. Shock-reinfusion injury to the central organs and the effect of free radical scavengers in the rat. Surg. Today. 23:1993;891-896.
7. Harbrecht B.G., Wu B., Watkins S.C., Marshall H.P., Peitzman A.B., Billiar T.R. Inhibition of nitric oxide synthase during haemorrhagic shock increases hepatic injury. Shock. 4:1995;332-337.
8. Joshi P.C., Grogan J.B., Thomae K.R. Effect of aminoguanidine on in vivo expression of cytokines and inducible nitric oxide synthase in the lungs of endotoxemic rats. Res. Commun. Mol. Pathol. Pharmacol. 91:1996;339-346.
9. Kapoor R., Prasad K. Role of oxyradicals in cardiovascular depression and cellular injury in haemorrhagic shock and reinfusion: Effect of SOD and catalase. Circ. Shock. 43:1994;79-94.
10. Kelly E., Shah N.S., Morgan N.N., Watkins S.W., Peizman A.B., Billiar T.R. Physiological and molecular characterization of the role of nitric oxide in hemorrhagic shock: Evidence that type II nitric oxide synthase does not regulate vascular decompensation. Shock. 7:1997;157-163.
11. Kilbourn R.G., Szabó C., Traber D. Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: Lessons learned from experimental and clinical studies. Shock. 7:1997;235-246.
12. G-methyl-L-arginine restores arterial pressure in hemorrhaged rats. Circ. Shock. 40:1993;47-52.
13. Lazarus H.M., Warnick T., Hutto W. Influence of a protein-free diet on survival and DNA following haemorrhagic shock and ischemia. Circ. Shock. 13:1984;171-181.
14. Leffler C.W., Passmore J.C. Effects of indomethacin on hemodynamics of dogs in refractory haemorrhagic shock. J. Surg. Res. 23:1994;392-399.
15. Lieberthal W., Mcgarry A.E., Sheils J., Valeri C.R. Nitric oxide inhibition in rats improves blood pressure and renal function during hypovolemic shock. Am. J. Physiol. 261:1991;F868-872.
16. Menezes J.M., Kane J.M., Peitzman A.B., Billiar T.R., Harbrecht B.G. Inhibition of inducible nitric oxide synthase reduces hepatic injury in hemorrhagic shock. Shock. 7 (Suppl.):1997;65. abstract.
17. Naziri W., Pietsch J.D., Appel S.H., Cheadle W.G., Bergamini T.M., Polk H.C. Haemorrhagic shock-induced alterations in circulating and bronchoalveolar macrophage nitric oxide production. J. Surg. Res. 59:1995;146-152.
18. Radi R., Rodriguez M., Castro L., Telleri R. Inhibition of mitochondrial electron transport by peroxynitrite. Arch. Biochem. Biophys. 308:1994;89-95.
19. Ruetten H., Thiemermann C. Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat. Biochem. Biophys. Res. Commun. 225:1996;525-530.
20. Salzman A.L., Vromen A., Denenberg A., Szabó C. Protective effects of glibenclamide, an inhibitor of ATP-activated potassium channels in a porcine model of hemorrhagic shock. Am. J. Physiol. 272:1997;H688-H697.
21. Sautebin L., Di Rosa M. Nitric oxide modulates prostacyclin biosynthesis in the lung of endotoxin-treated rats. Eur. J. Pharmacol. 262:1994;193-196.
22. Seibert K., Masferrer J.L. Role of inducible cyclooxygenase (COX-2) in inflammation. Receptor. 4:1994;17-23.
23. Southan G.J., Szabó C., Thiemermann C. Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br. J. Pharmacol. 114:1995;510-516.
24. Southan G.J., Zingarelli B., O'Connor M., Salzman A.L., Szabó C. Spontaneous rearrangement of aminoalkylguanidines into mercaptoalkylguanidines: A novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br. J. Pharmacol. 117:1996;619-632.
25. Sun X., Wei S., Szabó C., Dusting G.J. Depression of the inotropic action of isoprenaline by nitric oxide synthase induction in rat isolated hearts. Eur. J. Pharmacol. 320:1997;29-35.
26. Szabó C. Alterations in the production of nitric oxide in various forms of circulatory shock. New Horiz. 3:1995;3-32.
27. Szabó C. DNA strand breakage and activation of poly-ADP ribosyltransferase: A cytotoxic pathway triggered by peroxynitrite. Free Radic. Biol. Med. 21:1996;855-869.
28. Szabó C., Thiemermann C. Role of nitric oxide in haemorrhagic, traumatic and anaphylactic shock and in thermal injury. Shock. 2:1994;145-155.
29. Szabó C., Salzman A.L., Ischiropoulos H. Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo. FEBS Lett. 363:1995;235-238.
30. Szabó C., Salzman A.L., Ischiropoulos H. Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and haemorrhagic shock and ischemia-reperfusion injury. FEBS Lett. 372:1995;229-232.
31. Szabó C., Zingarelli B., O'Connor M., Salzman A.L. DNA strand breakage, activation of poly-ADP ribosyl synthetase and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl. Acad. Sci. USA. 93:1996;1753-1758.
32. Szabó C., Zingarelli B., Salzman A.L. Role of poly-ADP ribosyltransferase activation in the nitric oxide- and peroxynitrite-induced vascular failure. Circ. Res. 78:1996;1051-1056.
33. Szabó C., Ferrer-Sueta G., Zingarelli B., Southan G.J., Salzman A.L., Radi R. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J. Biol. Chem. 272:1997;9030-9036.
34. Tan L.R., Waxman K., Clark L., Eloi L., Chhieng N., Miller B., Young A. Superoxide dismutase and allopurinol improve survival in an animal model of haemorrhagic shock. Am. Surgeon. 59:1993;797-800.
35. Thiemermann C., Szabó C., Mitchell J.A., Vane J.R. Vascular hyporeactivity to vasoconstrictor agents and haemodynamic decompensation in haemorrhagic shock is mediated by nitric oxide. Proc. Natl. Acad. Sci. USA. 90:1993;267-271.
36. Vromen A., Szabó C., Southan G., Salzman A.L. Protective effects of isopropyl-isothiourea, a potent inhibitor of constitutive nitric oxide synthase in rodent and porcine models of haemorrhagic shock. J. Appl. Physiol. 81:1996;707-715.
37. 2 restores the depressed hepatocellular function and hepatic blood flow following hemorrhage and resuscitation. J. Surg. Res. 50:1991;368-374.
38. Wizemann T., Gardner C., Laskin J., Quinones S., Durham S., Goller N., Ohnishi T., Laskin D. Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia. J. Leukoc. Biol. 56:1994;759-768.
39. Yao Y.M., Bahrami S., Leichtfried G., Redl H., Schlag G. Significance of nitric oxide in hemorrhage-induced hemodynamic alterations, organ injury and mortality in rat. Am. J. Physiol. 270:1996;H1616-H1623.
40. Zingarelli B., Squadrito F., Altavilla D., Calapai G., Campo G.M., Caló M., Saitta A., Caputi A.P. Evidence for a role of nitric oxide in hypovolemic haemorrhagic shock. J. Cardiovasc. Pharmacol. 19:1992;982-986.
41. Zingarelli B., Caputi A.P., Di Rosa M. Dexamethasone prevents vascular failure mediated by nitric oxide in haemorrhagic shock. Shock. 2:1994;210-215.
42. Zingarelli B., O'Connor M., Wong H., Salzman A.L., Szabó C. Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J. Immunol. 156:1996;350-358.
43. Zingarelli B., Day B.J., Crapo J.D., Salzman A.L., Szabó C. The potential involvement of peroxynitrite in the pathogenesis of endotoxic shock. Br. J. Pharmacol. 120:1997;259-267.
44. Zingarelli B., Southan G.J., Gilad E., O'Connor M., Salzman A.L., Szabó C. The inhibitory effects of mercaptoalkylguanidines on cyclooxygenase activity. Br. J. Pharmacol. 120:1997;357-366.